Annisa Noviany’s scientific contributions

Background: DM is metabolic disease can prolong wound healing phase and cause oxidative stress that can affect cardiac damage such as degeneration, hypertrophy, and necrosis. They can be inhibited by the effect of 16 ml/kg BW CM containing palmitic acid (18.30%), albumin (3.6147g/dl), and amino acids are leucine (1.58%) and valine (0.97%). It's proven to accelerate wound healing in normal Wistar rats and DM. However, CM extract on the cardiac is unknown, so an acute toxicity test was carried out for 14 days. Purpose: To analyze the effect of oral administration of CM extract at an effective dose of 16 ml/kg BW on the histopathological exam of degeneration, hypertrophy, and cardiac necrosis of normal Wistar rats and diabetic models. Method: This study is true experimental study with a post-test only control group design which is divided into 4 groups are 2 groups of Wistar rats normal and diabetic models who were given CM extract at an effective dose of 16 ml/kg BW, 2 groups consisted of normal Wistar rats and diabetic models which were only given BR2 feed. Results: T-Independent test and the Mann-Whitney test showed that there was a significant difference between degeneration and hypertrophy (p<0.05) and necrosis. There was no significant difference (p>0.05). Conclusion: The effective dose of CM extract 16 ml/kg BW had an effect on the cardiac of normal Wistar rats and diabetic models in the form of a decrease in the level of damage to degeneration, hypertrophy, and cardiac necrosis. Keywords: Cardiac, Channa micropeltes, Degeneration, Hypertrophy, Necrosis.Background: DM is metabolic disease can prolong wound healing phase and cause oxidative stress that can affect cardiac damage such as degeneration, hypertrophy, and necrosis. They can be inhibited by the effect of 16 ml/kg BW CM containing palmitic acid (18.30%), albumin (3.6147g/dl), and amino acids are leucine (1.58%) and valine (0.97%). It's proven to accelerate wound healing in normal Wistar rats and DM. However, CM extract on the cardiac is unknown, so an acute toxicity test was carried out for 14 days. Purpose: To analyze the effect of oral administration of CM extract at an effective dose of 16 ml/kg BW on the histopathological exam of degeneration, hypertrophy, and cardiac necrosis of normal Wistar rats and diabetic models. Method: This study is true experimental study with a post-test only control group design which is divided into 4 groups are 2 groups of Wistar rats normal and diabetic models who were given CM extract at an effective dose of 16 ml/kg BW, 2 groups consisted of normal Wistar rats and diabetic models which were only given BR2 feed. Results: T-Independent test and the Mann-Whitney test showed that there was a significant difference between degeneration and hypertrophy (p<0.05) and necrosis. There was no significant difference (p>0.05). Conclusion: The effective dose of CM extract 16 ml/kg BW had an effect on the cardiac of normal Wistar rats and diabetic models in the form of a decrease in the level of damage to degeneration, hypertrophy, and cardiac necrosis. Keywords: Cardiac, Channa micropeltes, Degeneration, Hypertrophy, Necrosis.

Introduction: Recurrent aphthous stomatitis (SAR) is a recurrent ulceration lesion where many Streptococcus sanguis bacteria are found. Streptococcus sanguis bacteria can be killed by compounds that contain antibacterial. Kapul fruit (Baccaurea macrocarpa) is a typical Kalimantan fruit, has antioxidant and antibacterial activity which serves to kill Streptococcus sanguis. Method: Performed a quantitative phytochemical test on the kapul fruit peel and continued with the antibacterial activity test using the disc diffusion method of kapul fruit peel extract at the concentrations 20%, 40%, 60%, 80%, 100%,Chlorhexidine as a positive control and aquades as a negative (n=4/group). Result: From the phytochemical test, Kapul fruit peel extracts contain 35,851% of alkaloid, 23,225% of saponin, 2,395mg of tannin and 21,000mg of flavonoids. Kapul fruit peel extracts has the potential as an antibacterial against Streptococcus sanguis at concentration of 40%, 60%, 80% and 100%. The concentration at 100% has an equivalent to chlorhexidine as an antibacterial potential. Conclusion: The potential of Kapul peel Extract as antibacterial to Streptococcus sanguis bacteria on 40%, 60%, 80%, 100% concentration. The concentration at 100% has an equivalent to chlorhexidine as an antibacterial potential.