Anne-Marie Minihane's research while affiliated with University of East Anglia and other places

Publications (40)

Article
Full-text available
Background Large-scale trials of multidomain interventions show that modifying lifestyle and psychological risk factors can slow cognitive decline. We aim to determine if a lower intensity, personally tailored secondary dementia prevention programme for older people with subjective or mild objective memory decline, informed by behaviour change theo...
Article
Full-text available
Female APOE4 carriers have a greater predisposition to developing Alzheimer’s disease (AD) compared to their male counterparts, which may partly be attributed to menopause. We previously reported that a combination of menopause and APOE4 led to an exacerbation of cognitive and neurological deficits, which were associated with reduced brain DHA and...
Article
Full-text available
There is a drive in the UK to harness findings from novel fundamental and efficacy nutritional research and, through inter-disciplinary and multi-agency collaborations, to improve eating behaviour for the benefit of population health. This report summarises the progress made during the Medical Research Council-funded Hot Topic workshop on the plann...
Article
Full-text available
The impact of sex and menopausal status in Alzheimer’s disease remains understudied despite increasing evidence of greater female risk, particularly in APOE4 carriers. Utilizing female APOE‐TR mice maintained on a high‐fat diet background we induced ovarian failure through repeated VCD injections, to mimic human menopause. At 12 months of age, reco...
Article
Full-text available
Docosahexaenoic acid is the main long-chain omega-3 polyunsaturated fatty acids in the brain and accounts for 30-40% of fatty acids in the grey matter of the human cortex. Although the influence of docosahexaenoic acid on memory function is widely researched, its association with brain volumes is under investigated and its association with spatial...
Poster
Full-text available
Volume 29, Issue S1 Special Issue: Abstracts of the 25th Congress of the European Sleep Research Society, 22‐24 September 2020, Virtual Congress September 2020
Article
Full-text available
The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At ba...
Article
Full-text available
With an ageing global population, there is an urgent need to identify effective strategies to maintain brain health across the life course and therein minimise the risk of age‐related neurodegenerative disorders reaching a severe stage which may manifest as dementia. An increasing body of evidence indicates that nutrition is a modifiable lifestyle...
Article
Full-text available
Background: The endothelium plays a key role in the maintenance of vascular health and represents a potential physiological target for dietary and other lifestyle interventions designed to reduce the risk of cardiovascular diseases (CVD) including stroke or coronary heart disease. Objective: To conduct a systematic review and meta-analysis of ra...
Article
Navigation processes that are selectively mediated by functional activity in the entorhinal cortex may be a marker of preclinical Alzheimer's disease (AD). Here, we tested if a short path integration paradigm can detect the strongest genetic-risk phenotype of AD in large sample of apolipoprotein E (APOE)-genotyped individuals. We also examined the...
Article
Full-text available
Purpose The health-promoting potential of food-derived plant bioactive compounds is evident but not always consistent across studies. Large inter-individual variability may originate from differences in digestion, absorption, distribution, metabolism and excretion (ADME). ADME can be modulated by age, sex, dietary habits, microbiome composition, ge...
Preprint
Navigation processes mediated selectively by the entorhinal cortex (EC) may be impaired in individuals with suspected preclinical Alzheimers disease (AD) but the clinical utility of navigation tests to detect such impairments remains to be established. In a sample of 64 individuals (32 e3e3 and 32 e3e4) we tested whether an existing paradigm the Vi...
Article
Full-text available
Background: In Mediterranean countries, adherence to a traditional Mediterranean dietary pattern (MedDiet) is associated with better cognitive function and reduced dementia risk. It is unclear if similar benefits exist in non-Mediterranean regions. Objectives: The aims of this study were to examine associations between MedDiet adherence and cogn...
Article
Full-text available
Background Anthocyanin-rich blueberry intake is associated with reduced type 2 diabetes and cardiovascular disease (CVD) risk in prospective studies, although long-term randomized controlled trials (RCTs) have not been conducted in at-risk populations. Objective In the longest-duration RCT to date, we examined the effect of 6-mo blueberry intake o...
Article
Full-text available
Spatial navigation is emerging as a critical factor in identifying preclinical Alzheimer’s disease (AD). However, the impact of interindividual navigation ability and demographic risk factors (e.g., APOE, age, and sex) on spatial navigation make it difficult to identify persons “at high risk” of AD in the preclinical stages. In the current study, w...
Article
Full-text available
Apolipoprotein E (APOE) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic mechanisms. However, a comprehensive understanding of the impact of APOE genotype on microflora speciation and metabolism is completely lacking. In this study, we investigated the...
Article
Full-text available
We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured...
Preprint
Apolipoprotein E (APOE) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease. Numerous studies have provided insights into the pathological mechanisms. However, a comprehensive understanding of the impact of APOE genotype on microflora speciation and metabolism is completely lacking. The aim of this study was to investiga...
Article
Diet and physical activity play key roles in maintaining health and preventing or delaying disease. The global prevalence of dementia, an umbrella term describing a set of symptoms which affect cognitive function, is set to rise dramatically by 2050, with current drug treatments inadequate. Diet and physical activity are modifiable factors in demen...
Article
Full-text available
Introduction: The Cognitive Ageing, Nutrition and Neurogenesis trial hypothesizes that a combined intervention with long-chain n-3 polyunsaturated fatty acids (n-3) and cocoa flavan-3-ols (FLAV) will mitigate the cognitive decline anticipated to naturally occur over 1 year in older adults. Methods: In a double-blinded, placebo-controlled parallel...
Article
Full-text available
Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of develop...
Article
An apolipoprotein E ε4 (APOE-ε4) genotype is the strongest common genetic determinant of Alzheimer's disease (AD). The pleiotropic nature of apolipoprotein E has made elucidation of the aetiological basis difficult to establish, which is further complicated by the fact that the penetrance of the APOE-ε4 allele is modulated by sex, age, and nutritio...
Preprint
Full-text available
INTRODUCTION Spatial navigation is emerging as a critical factor in identifying pre-symptomatic Alzheimer pathophysiology, with the impact of sex and APOE status on spatial navigation yet to be established. METHODS We estimate the effects of sex on navigation performance in 27,308 individuals (50-70 years [benchmark population]) by employing a nov...
Article
Full-text available
At a population level, there is growing evidence of the beneficial effects of dietary flavonoids on health. However, there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide interindividual variability in flavonoid absorption and metabolism. Flavonoids are extensively metabolized by phase I and phase I...
Article
Full-text available
As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies....
Article
The aim of this review was to determine the impact of the fatty acid desaturase ( FADS ) genotype on plasma and tissue concentrations of the long-chain (LC) n -3 PUFA, including EPA and DHA, which are associated with the risk of several diet-related chronic diseases, including CVD. In addition to dietary intakes, which are low for many individuals,...
Article
Full-text available
Lipoprotein lipase (LPL) is a key rate-limiting enzyme for the hydrolysis of triacylglycerol (TAG) in chylomicrons and very low-density lipoprotein. Given that postprandial assessment of lipoprotein metabolism may provide a more physiological perspective of disturbances in lipoprotein homeostasis compared to assessment in the fasting state, we have...
Article
Full-text available
Background: There is much speculation with regard to the potential cardioprotective benefits of equol, a microbial-derived metabolite of the isoflavone daidzein, which is produced in the large intestine after soy intake in 30% of Western populations. Although cross-sectional and retrospective data support favorable associations between the equol pr...
Article
Full-text available
Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a s...

Citations

... Here, the improvement of spatial learning tasks in Rg-mice appeared to be linked to the successful development and survival of granule cells in the hippocampal network of these mice, a process that has been shown to be critical to spatial learning related memory. 107,108 In addition, the upregulated expression of ST8sia2 and Ncam1 in Rg-mice is in line with the importance of PSA-NCAM for the development and adult neuroplasticity. 109,110 These effects may be mediated by the increased levels of tryptophan and indoles in Rg-mice, as recent studies showed that microbial-derived indoles have neuroprotective properties, can cross the BBB, and rescue neurogenesis in GF mice. ...
... It has been suggested that spatial navigation impairment, in particular for allocentric and real space configurations, occurs early in the development of AD and can be used for monitoring disease progression or for evaluation of presymptomatic AD (Hort et al., 2007). Recent studies suggest that midlife APOE4 carriers exhibit changes in navigation patterns before any detectable symptom onset (Coughlan et al., 2018). ...
... Prior research has suggested that a constellation of video games can be employed to obtain measures that approximate general problem-solving skills (e.g. fluid intelligence g) 32,33 , while other applications have demonstrated that gameplay can be designed around a single cognitive function to extract biomarker-like information about a player's cognitive abilities 35,36 , in line with age-based 35,37 and gender-based 38 expectations of differences in cognition. In doing so, researchers need to account for prior gaming expertise since seasoned gamers can outperform novice gamers even if the game in question is novel for all participants 38-40 . ...
... There is therefore a need to identify effective strategies which help facilitate healthy brain ageing and minimize dementia risk. Dietary strategies including consumption of bioactive compounds (e.g., n-3 fatty acids and b vitamins), foods (e.g., blueberries and green leafy vegetables) or healthy dietary patterns [e.g., Mediterranean diet or MIND diet (a hybrid between the Mediterranean diet and dietary approach to stop hypertension)] may play a role in this regard [3][4][5][6]. ...
... There has been an increasing interest in the APOE cohort as a disease model for incipient cognitive changes for AD. Previous studies have shown that APOE carriers at increased genetic risk show changed navigation behavior with overshooting of navigation targets and preference for border areas (Coughlan, Zhukovsky, et al., 2020). It has been speculated that APOE induced grid cell changes in the entorhinal cortex and are responsible for these specific navigation changes, as distance traveled and landmark spatial resetting are critical factors mediated by the entorhinal cortex (Kunz et al., 2015). ...
... Yubero-Serrano EM et al. showed that a 1-year intervention with the Mediterranean diet decreased ROS production, cellular apoptosis, and endothelial cell senescence and improved endothelial function in coronary heart disease patients [114]. A meta-analysis revealed that intervention with the Mediterranean diet significantly improves endothelial function in patients with increased risk of cardiovascular disease, and even in healthy subjects and that the duration of the Mediterranean diet intervention is positively correlated with endothelial function [115]. Some studies have demonstrated that higher adherence to the Mediterranean diet could improve endothelial function [116,117]. ...
... However, their incorporation is limited in food bioactives or natural products. One of the main advantages is the absence of inter-individual variability affecting ADMET parameters such as age, sex, dietary habits, microbiome composition, genetic variation, drug exposure, etc. [42,43]. Moreover, in such in vitro systems, the interference of the endogenously produced metabolites is avoided. ...
... Novel spatial navigation measures, the Virtual Supermarket Task (VST) and Sea Hero Quest (SHQ) identify cognitive changes due to functional neural abnormalities within the spatial navigation network (particularly the entorhinal cortex and hippocampus) in at-geneticrisk AD, making them sensitive and specific measures for preclinical AD disease [2,[9][10][11]. Until now however, spatial navigation studies have overlooked the need to establish the testretest reliability of these measures in preclinical AD populations, opting to focus on cross-sectional group comparisons or self-report scales [12], with one exception [13]. a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 ...
... There is some suggestive evidence that the Mediterranean Diet (Estruch et al., 2018;Rees et al., 2019;Hu et al., 2020) and its various iterations along with the DASH (Dietary Approach to Stop Hypertension) diet (Bathrellou et al., 2019;Chiavaroli et al., 2019) may have protective effects on the cardiovascular system. This theory led to the idea that the DASH and Mediterranean Diets may be neuroprotective (Blumenthal et al., 2019;Shannon et al., 2019;van den Brink et al., 2019). Sofi et al. (2008) conducted a meta-analysis on the beneficial effects of adherence to the Mediterranean diet on mortality and the prevention of major chronic diseases, including Alzheimer's disease. ...
... Conversely, in a double-blind, placebo-controlled, parallel arms trial, a group of 115 obese or overweight subjects with metabolic syndrome received a daily serving of either 13 or 26 mg freeze-dried highbush blueberry powder (equivalent to half a cup or one cup of fresh berries) providing 182 mg or 364 mg ACN, for six months. While markers of endothelial function improved, no effect was observed on SBP or DBP [66]. ...