Anna Takaoka's research while affiliated with City University of New York - Hunter College and other places

Publications (5)

Article
Juzen-taiho-to (JTT) is an immune-boosting formulation of ten medicinal herbs. It is used clinically in East Asia to boost the human immune functions. The active factors in JTT have not been clarified. But, existing evidence suggests that lipopolysaccharide (LPS)-like factors contribute to the activity. To examine this possibility, JTT was subjecte...
Article
Juzen-taiho-to is an immunostimulatory herbal formulation that is clinically used in East Asia for cancer patients undergoing chemotherapy and radiation. The formulation stimulates various leukocytes, including T, B, and NK cells and macrophages. Although Juzen-taiho-to is known to contain numerous compounds with various pharmacological activities,...
Article
Reproducibility is an important issue in biological characterization of drug candidates and natural products. It is not uncommon to encounter cases in which supposedly the same sample exhibits very different biological activities. During our characterization of macrophage-stimulatory lipids from herbal medicine, it was found that the potency of the...
Article
From Toki-shakuyaku-san, an herbal formulation for 'cleansing stagnated blood,' a key gene regulatory compound was purified and identified through a screening based on DNA microarray and real-time PCR.
Article
A screening methodology called 'genomic screening' was established to identify natural products that can regulate cellular gene expression. Application of genomic screening to Keishi-bukuryo-gan (KBG), a Japanese herbal medicine formulation, identified a previously unnoticed transcriptional effect by linoleic acid, a known KBG component. The approa...

Citations

... However, while vegetable leaves are well populated with bacteria including potential probiotic acting Lactobacillus strains [34][35][36][37], so far, plant-derived produce has only been considered as vehicles of probiotic cultures [38,39]. A detailed understanding of how probiotic bacteria colonize leafy vegetables or herbs would enable future approaches to enrich these tissues with the respective bacterial strains to elevate vegetable leaves beyond their basic nutritional values. ...
... Many studies observed that plant extracts stimulated matured DCs to increase Tcell proliferation and production of immunostimulatory cytokines such as the T helper cytokines (Th1) IL-12 and IFN-γ [49], which are shown in Table 3. The extract of the Kurosengoku Japanese soybean initiates the production of IFN-γ and IL-12 from DCs [50]. Another group found that the active component galactomannan isolated from the Caesalpinia spinosa plant gives rise to the maturation of DCs and also increases mRNA levels of proinflammatory cytokines [51]. ...
... 14 Nnps are usually composed of proteins, polysaccharides, and lipids. [15][16][17][18][19] Importantly, Nnps can adsorb active constituents, 17,[20][21][22] carry them for absorption, 20,23,24 and distribute them to target tissues. 17 These results suggest that Nnps may affect the pharmaceutical and pharmacokinetic properties of the active constituents in herbal extracts. ...
... Furthermore, it is important to include advances in molecular biology for development of new biological test models. This is exemplified by the use of a genomic screening method with capacity to identify molecules in a herbal mixture that can regulate cellular gene expression (Kawamura et al., 2006). Again, a well-known ompound such as linolenic acid was identified as the regulator of specific genes by such an approach. ...
... Previous studies have indicated that TSS improves iron deficiency anemia [6][7][8] and leukorrhagia [9]. Moreover, it had been reported that TSS may increase cerebral blood flow [10,11], reduce oxidative stress in the central nervous system [12], inhibit platelet aggregation [13], regulate thrombosis in endothelial cells [14], and relax vascular smooth muscle [15]. Table 1 shows the comparative clinical symptoms and signs between Flammer syndrome and the indications for use of TSS. ...