Anna Perez's research while affiliated with University Medical Center Hamburg - Eppendorf and other places
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Publications (15)
Mucolipidosis type II (MLII), an ultra-rare lysosomal storage disorder, manifests as a fatal multi-systemic disease. Mental inhibition and progressive neurodegeneration are commonly reported disease manifestations. Nevertheless, longitudinal data on neurocognitive testing and neuroimaging lack in current literature. This study aimed to provide deta...
Background
Thyroid dysfunction during pregnancy is relatively common and can cause obstetric complications and significantly influence fetal development.
Aims
We aimed to evaluate postnatal clinical and laboratory characteristics in the first days of life in infants born to mothers with a thyroid disorder.
Study design and subjects
We conducted a...
Background: The SARS-COVID-19 pandemic and its associated disease control restrictions have in multiple ways affected families with young children, who may be especially vulnerable to mental health problems. Studies report an increase in perinatal parental distress as well as symptoms of anxiety or depression in children during the pandemic. Curren...
Purpose
To assess maternal mental health during the first weeks after birth including birth experience, postpartum adjustment to early motherhood and the perception of newborn behaviour, and how this may be influenced by the first wave of the COVID-19 pandemic.
Methods
Ninety women who gave birth after the first enforcement of nation-wide disease...
Background:
Advances in neonatology now enable increasing numbers of very low birth weight neonates (<1500 g) to survive into early adulthood and beyond. What are the implications for their long-term care?
Methods:
Selective literature search on the outcome of very low birth weight neonates in adulthood ("adults born preterm").
Results:
Robust...
Introduction:
Monogenic diseases play an important role in critically ill neonates and infants treated in the intensive care unit. This study aimed to determine the diagnostic yield of whole-exome sequencing (WES) for monogenic diseases and identify phenotypes more likely associated with a genetic etiology.
Methods:
From March 2017 to 2020, a co...
Background
Mucolipidosis type II (MLII) is an ultra-rare lysosomal storage disorder caused by defective lysosomal enzyme trafficking. Clinical hallmarks are craniofacial dysmorphia, cardiorespiratory dysfunction, hepatosplenomegaly, skeletal deformities and neurocognitive retardation. Death usually occurs in the first decade of life and no cure exi...
Introduction: Adults Born Very Preterm (ABP) are an underperceived but steadily increasing patient population. It has been shown that they face multiple physical, mental and emotional health problems as they age. Very little is known about their specific health care needs beyond childhood and adolescence. This article focuses on their personal pers...
This study aimed to identify peripartum and neonatal factors associated with elevated Interleukin-6 levels in the cord blood of neonates without clinical signs of an infection.
We conducted a prospective single-center study with healthy term and preterm neonates between March and November 2017. We investigated correlations between 21 peripartum fac...
Background: Although thermal care is part of the daily routine in Neonatal Intensive Care Units (NICUs), scientific evidence on what is the appropriate body temperature for very low birth weight infants (VLBWI) is largely lacking.
Aim: To find out to what extent the standards of thermal care vary among high-level NICUs, especially with respect to t...
Citations
... Unklar ist, inwieweit auch die frühkindliche Entwicklung und Gesundheit beeinflusst wurden. Einerseits wurde eine Zunahme von Regulationsschwierigkeiten und kindlichen Entwicklungsverzögerungen beobachtet [13], andererseits gibt es empirische Hinweise auf positive Auswirkungen der Familiensituation in der Pandemie, bspw. bezüglich stärker prosozialen Verhaltens der Kinder [14]. ...
... A cohort study of 833 pregnant women, assessed once during pregnancy and second at 12 weeks postpartum to consider risk and resilience factors for mother-infant bonding, reported that covid related distress and prenatal depression and anxiety predicted a greater likelihood of postpartum depression and poor mother-infant bonding [23]. However, few studies reported no difference in bonding levels despite postpartum depression., but their limitation was covid negative status, cross-sectional, and no accountability of covid-related worries(alter bonding) and breastfeeding practices(Enhance bonding) in those studies [24,25]. Our study included covid positive women; hence, more COVID-19-related stress and breastfeeding worries can affect the quality of a mother's interaction with her infant during feeding or play. ...
... Like prematurity, birth weight is a relevant parameter for public health. LBW is associated with hypertension, sleep-disordered breathing, kidney disease, neurodevelopmental and psychiatric disorders, and metabolic risk (35,36). SGA is a risk factor for a number of diseases from the neonatal period to adulthood. ...
... (107/163). WES is a powerful diagnostic tool in critically ill neonates and infants with a high diagnostic rate (Scholz et al. 2021). This nding indicates that the application of WES for fetal prenatal diagnosis can effectively reduce the number of births of children with genetic diseases. ...
... Evidence on the efficacy of HSCT in MLII is still scarce. The combined international experience in the use of HSCT for MLII are only 23 patients, and only 3 cases have been reported in detail (11)(12)(13). Hematopoietic donor cells can produce functional M6Pcontaining lysosomal enzymes, which can be taken up intracellularly and transported to lysosomes for the degradation of macromolecules (14). ...
... We are aware of just one other published qualitative study about the experiences of adults born preterm. 12 Because most adult healthcare providers have yet to acknowledge and factor this experience into patient care, individuals born preterm are finding alternative avenues to be seen. Adults born preterm report seeking online community and support, connecting globally with people over shared early life experiences, while simultaneously making their needs and identities known. ...
... They attempt to satisfy high energetic needs by using glucose from still low glycogen and even structural protein stores [124], frequently resulting in depletion and hypoglycemia. Adding to this, immaturity of enzymatic activity may limit metabolic defense processes for several weeks [125][126][127]. Undiagnosed and untreated, hypoglycemia causes brain damage and may lead to death. ...
... The concentration of IL-6 in fetal blood appears to change with advancing gestational age [309,310] and with the presence or absence of labor [311][312][313][314][315][316]. Therefore, consideration should be given to the original findings that were based on preterm gestations and that the results and cutoff values may differ if sampling occurs after labor (i.e., umbilical cord blood obtained after spontaneous labor). ...
... For athletes and other professional fields, the ability to monitor body temperature without affecting athletic performance during exercise is critical to analyze the actual metabolism and real-time status of the body, adjust the off-site training plan, and reasonably distribute stamina consumption on the field [14]. 5. ...