Anna Dierking’s research while affiliated with Hannover Medical School and other places

... As previous studies shown, α-smooth muscle actin (α-SMA), smooth muscle protein-22α (SM22α), calponin, and myosin heavy chain 11 (MYH11) are specific markers of contractile vascular SMCs. Although there are many hypotheses about the pathogenesis of AD, the exact cause is still unclear [8]. ...

Reference:

Long non-coding RNA HIF1A-AS2 modulates the proliferation, migration, and phenotypic switch of aortic smooth muscle cells in aortic dissection via sponging microRNA-33b

... In light of all this evidence, new information on genetic variants may affect the clinical management of patients who have had genetic testing in the past. Although there is currently no consensus as to when and how often variants should be reclassified, 40 variant reclassification in previously published cohorts and work with curators of variant databases to update the information for the erroneously classified variants has become an important task in modern genetics. Moreover, when using information about previously published variants associated with a condition for variant classification (e.g., to determine mutational hotspots or variants affecting the same codon), their pathogenicity should also be evaluated critically. ...

Reference:

Alanyl-tRNA Synthetase 1 Gene Variants in Hereditary Neuropathy: Genotype and Phenotype Overview

... genecards.org) [22] and Comparative Toxicogenomics Database (http://ctdbase.org/, CTD) [23] was used to obtain allergic asthma-related targets. ...

Reference:

Network pharmacology and experimental evidence: MAPK signaling pathway is involved in the anti-asthma roles of Perilla frutescens leaf

... A formal assessment was defined as a systematic and standardized process using health Gene Cards (15,16) and the similar National Center for Biotechnology Information GeneReviews were excluded as their focus is on guiding individual clinician decision-making (15,17,18). Omics tests encompass genomics, transcriptomics, proteomics, and metabolomics. ...

Reference:

A scoping review of the assessment reports of genetic or genomic tests reveals inconsistent consideration of key dimensions of clinical utility