Anlin Yin's research while affiliated with Jiaxing University and other places

Publications (27)

Article
Full-text available
The cells and tissue in the human body are orderly and directionally arranged, and constructing an ideal biomimetic extracellular matrix is still a major problem to be solved in tissue engineering. In the field of the bioresorbable vascular grafts, the long-term functional prognosis requires that cells first migrate and grow along the physiological...
Article
Nanofibre membranes with a small diameter and a large specific surface area are widely used in the filtration field due to their small pore size and high porosity. To date, aramid nanofibres (ANFs) have received extensive research interest because of their high stiffness and excellent temperature resistance. However, the preparation of ANFs usually...
Article
A feasible approach to fabricate porous nanofibrous scaffolds structurally similar to native extracellular matrix was reported. Magnesium oxide (MgO) nanoparticles were incorporated into electrospun poly(lactic acid) (PLA)/gelatin membranes, which were processed into short fibers and reconstructed to three-dimensional scaffolds. The scaffold exhibi...
Article
In order to obtain a synergistic antimicrobial effect of cuprous oxide nanoparticles (Cu2O NPs) and chitosan (CS) nanofibers, the nano Cu2O/CS nanofibrous scaffolds were synthesized in situ via two subsequent steps of chelation and reduction. The Cu2+ were stably chelated on CS nanofibrous scaffolds through the coordination of amino group (-NH2) an...
Article
Bacterial infections cause severe secondary damage to wounds and hinder wound healing processes. We prepared magnesium oxide (MgO) nanoparticle-incorporated nanofibrous membranes by electrospinning and investigated their potential for wound dressing and fighting bacterial infection. MgO-Incorporated membranes possessed good elasticity and flexibili...
Article
The bioprosthetic heart valve (BHV) has attracted considerable attention in clinical practice. However, complications of the BHV such as thrombosis, calcification, and early deterioration after implantation have limited further applications. In the present study, we provide a strategy to fabricate an anti-biofouling BHV by constructing interpenetra...
Article
The attachment of bio-foulants, including unwanted cells, proteins, and bacteria, to a medical device such as an intraocular lens can lead to implantation failure. Hydrophilic polymers are often used as surface modifiers in the fabrication of anti-biofouling coatings, but a hydrophilic coating can easily become swollen and peel off the substrate. I...
Article
Small-diameter artificial vascular grafts modified with layer-by-layer (LBL) coating show promise in reducing the failure caused by thrombosis and inflammation, but undesirable stability and bioactivity issues of the coating and payload usually limits their long-term efficacy. Herein, inspired by catechol/gallol surface chemistry, a sandwiched laye...
Article
The fabrication of a functional small-diameter vascular graft with good biocompatibility, in particular hemocompatibility, has become an urgent clinical necessity. We fabricated a native bilayer, small-diameter vascular graft using PEGylated chitosan (PEG-CS) and poly (L-lactic acid-co-ε-caprolactone; PLCL). To stabilize the inner layer, a PEG-CS b...
Article
In this study, we fabricated native tissue mimicking a bilayered small-diameter vascular graft based on PEGylated chitosan (PEG–CS) and poly(l-lactic acid-co-ε-caprolactone) (PLCL). PEG–CS possesses good hemocompatibility, and as the inner layer of a vascular graft, it is more likely to swell and deform to debris, causing a blood clot, so the PLCL...
Article
Small diameter vascular grafts possessing desirable biocompatibility and suitable mechanical properties have become an urgent clinic demand. Herein, heparin loaded fibrous grafts of collagen/chitosan/poly(L-lactic acid-co-ε-caprolactone) (PLCL) were successfully fabricated via coaxial electrospinning. By controlling the concentration of heparin and...
Article
Polymeric nanoscale drug carrier systems are of particular interest for tumor therapy, offering significant advantages of improved targeting and efficacy. Herein, a well-defined polymeric micelle as drug carrier system is demonstrated with the functions of polypeptide based biodegradability and zwitterionic polyphosphorylcholine based biocompatibil...
Article
Full-text available
The construction of a smooth muscle layer for blood vessel through electrospinning method plays a key role in vascular tissue engineering. However, smooth muscle cells (SMCs) penetration into the electrospun graft to form a smooth muscle layer is limited due to the dense packing of fibers and lack of inducing factors. In this paper, silk fibroin/po...
Article
In this study, we prepared fusion proteins containing diverse combinations of PTDs such as Tat and 9R, and protein to find an optimum combination for efficient transduction effect. Various combinations of PTDs were fused with green fluorescent protein (GFP) in a recombinant way, which allows intracellular protein trafficking and measurement of tran...
Article
The Poly(L-lactide-co-caprolactone)/collagen/chitosan (P(LLA-CL)/COL/CS) composite grafts were electrospun in this study. Based on the testing results of mechanical properties, biodegradability and in vitro cellular compatibility, the optimal weight ratio of P(LLA-CL) to COL/CS was set as 3:1. In vivo study was further performed in a canine femoral...
Article
A novel electrospun nanoyarn scaffold, aimed to improve cell infiltration and vascularization, as well as guide cell behaviors by its biomimetic structure, was fabricated for tissue engineering. Electrospun nanofibers were deposited and twisted into yarns in a water vortex before collecting on a rotating mandrel to form a nanoyarn scaffold. Field e...
Article
Type I collagen is a widely used biomaterial in clinical skin or tissue repairing due to its natural source, good water-solubility, excellent biocompatibility, suitability for cell adhesion and growth [1]. Since the exciting discovery that collagen and polyvinyl pyrrolidone (PVP) hybrid based solutions and hydrogels exhibit favorable anti-inflammat...
Article
For blood vessel tissue engineering, an ideal vascular graft should possess excellent biocompatibility and mechanical properties. For this study, a elastic material of poly (L-lactic acid-co-ϵ-caprolactone) (P(LLA-CL)), collagen and chitosan blended scaffold at different ratios were fabricated by electrospinning. Upon fabrication, the scaffolds wer...
Article
Full-text available
Hydrogels are high in water content and have physical properties similar to native extracellular matrix (ECM), and thus they have been widely studied as three-dimensional (3D) tissue engineering scaffolds for cell culture. In this work, a two-step process was introduced to fabricate injectable hydrogel from oxidized dextran (ODex), amino gelatin (M...
Article
In this paper, novel nano-yarn reinforced scaffolds were fabricated and further biomineralized by submerging in 10×Simulated Body Fluid (SBF). The compressive strength of P(LLA-CL)/Silk Fibroin (SF) nano-yarns reinforced scaffold was 1.72±0.50 MPa and its porosity is 82.8%. Fourier Transform Infrared Spectrum (FTIR) and X-ray Diffraction (XRD) data...
Article
Nanofibrous scaffolds of silk fibroin (SF) and poly(l-lactic acid-co-ɛ-caprolactone) (P(LLA-CL)) blends fabricated via electrospinning possessed good mechanical property and biocompatibility, as demonstrated by a previous study in vitro. However, the degradation behavior of the scaffolds, which may significantly influence tissue repair and regenera...
Article
To improve water-resistant ability and mechanical properties of silk fibroin (SF)/hydroxybutyl chitosan (HBC) nanofibrous scaffolds for tissue-engineering applications, genipin, glutaraldehyde (GTA), and ethanol were used to crosslink electrospun nanofibers, respectively. The mechanical properties of nanofibrous scaffolds were obviously improved af...

Citations

... Currently, the commercial high-temperature air filtration materials mainly include glass fibers, polyimide (PI) fibers, and aramid fibers, which all feature with micro-sized fiber diameters [9][10][11]. Resulting from the accumulation of fibers, the pores are relatively large, and lead to difficulties in achieving high filtration efficiency towards small but poisonous PM 2.5 [12,13]. As an alternative, electrospun nanofibers have gained the attention of researchers, owing to their small fiber diameters, which would contribute to small pores and large specific surface area, all being beneficial to high air-filtration performance [14,15]. ...
... Sufficient vascularization also contributes to neuroregeneration. PLLA composite scaffolds have been widely applied in artificial blood vessels, and there are emerging studies to fabricate prevascularized PLLA-based scaffolds for angiogenesis-mediated nerve regeneration (Shen et al., 2021;Song et al., 2021). Moreover, future studies need to look into developing novel PLLA-based composites blended with other bioactive synthetic/natural polymers and combining various modification strategies corresponding to the strict demands for guiding nerve cell migration and axonal extension. ...
... Lin et al. produced PAN/perovskite nanoparticles LaCoO 3 perovskite nanoparti-cles@nitrogen-doped carbon ESs for a robust and efficient oxygen electrocatalyst for Zn-air batteries [215]. Zhou et al. reported a stable fabrication of nano Cu 2 O on CS with Cu 2+ as well as Vitamin C as reducing agent using non-toxic or non-hazards reducing agents [216]. ...
... Since toluene concentration of 80% produced damaged and intact morphology during sonication and stirring, respectively, effect of temperature rise, during sonication, on morphology needs to be carefully sorted out. Chen et al. received different weight fraction of gelatin/PLA nanofiber (1 cm 2 × 1 cm 2 ) membranes in ter-butanol solvent to prepare short nanofibers for 3D-scaffolding [85][86][87][88]. The mixture was homogenized for 15 min at 12,000 rpm. ...
... Grasl et al. (Grasl et al., 2021) tried to use thermoplastic polyurethane (PUR) and polylactic acid (PLLA) to prepare axial, circumferential, and randomly arranged fiber prostheses by electrospinning and found that different fiber structures had different mechanical properties, and even vascular prostheses with good mechanical properties comparable to those of natural blood vessels could be obtained by adjusting the fiber structure. A vascular graft requires good antiplatelet properties, and the materials must possess a good antifouling ability (Yang Lei et al., 2021;He et al., 2022). Therefore, materials are required to have proper hydrophilicity. ...
... Wang et al. developed a nanocomposite scaffold composed of iron oxide nanoparticles and showed antioxidant and substantial antibacterial properties in an in vitro study (52). Nanocomposites, including zinc oxide and magnesium oxide, seem to promote wound healing through their antibacterial activity (53,54). Thus, developing materials with powerful antioxidant and antibacterial activities is challenging for researchers. ...
... In our previous publications, we discussed the relationship between antifouling and surface wettability (He et al., 2021a;He et al., 2021b;Lan et al., 2021;Lei et al., 2021). For example, we summarized the frequent strategies to achieve anti-biofouling polymers for biomedical applications based on different types of surface wettability (He et al., 2021a), including superhydrophilicity ( Figure 1A), hydrophilicity ( Figure 1B), hydrophobicity ( Figure 1C), and superhydrophobicity ( Figure 1D). ...
... More importantly, color doppler ultrasound imaging demonstrated prominent vascular patency in the fiber graft. Although the functions of electrospun fiber-based vascular scaffold are continuously optimized, thrombosis and intimal hyperplasia still inevitably occurred [303]. The addition of a variety of bioactive substances can be beneficial to accelerating the replacement of autologous blood vessels and improving the treatment of cardiovascular diseases [304]. ...
... Both natural and synthetic biomaterials, along with crosslinking agents, are extensively used 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 156, 165 including poly(lactide-co-glycolide) (PLGA) 166 , PEG, poly(4-hydroxybutyrate) (P4HB), polyhydroxyoctanoate, PCL 167 , polydioxanone (PDO), PU, poly-L-lactic acid (PLLA) 165 , poly(lactide-co-caprolactone) (PLCL) 168 and polycarbonate polyol (PCU) 169 . ...
... Vascular graft implantation has emerged as the main therapeutic procedure to treat cardiovascular diseases [1][2][3] . Good compatibility and rapid endothelialization are two prerequisites for the clinical application of vascular grafts, especially for smallcaliber artificial vascular grafts ( < 6 mm) [4][5][6] . ...