Ankit Saneja’s research while affiliated with Institute of Himalayan Bioresource Technology and other places

... The synthesized COF was further explored for the delivery of Gemcitabine (Gem), a pyrimidine nucleoside analog. Gem is widely used, either alone or in combination with other chemotherapeutic agents or radiation therapy, to treat a range of cancers, including pancreatic, ovarian, bladder, breast, and non-small-cell lung cancers [24]. Further, Gem exhibits poor loading efficiency when entrapped into polymeric and lipid-based nanoparticles. ...

Reference:

An Imine-Based Two-Dimensional Covalent Organic Framework for Gemcitabine Delivery

... The study confirms SSG's suitability for 3D printing of OTFs. accurate dosing, enhanced oral absorption, improved bioavailability through minimization of drug degradation, better stability, dose tunability, portability, etc. [4]. Three-dimensional (3D) printing has become increasingly important in drug delivery since it offers a safer and more effective method for administering potent therapeutics [5,6]. ...

Reference:

Evaluating Swellable Cross-Linked Biopolymer Impact on Ink Rheology and Mechanical Properties of Drug-Contained 3D-Printed Thin Film

... As already stated, the application of these 3D platforms and models is of particular interest in cancer research [9]. In fact, several studies have reported the 3D bioprinting of tumor models, as well as their use for anti-tumoral drug screening and testing, as recently summarized by Ruchika et al. [10] and Li et al. [11]. Furthermore, 3D bioprinting has been successfully explored for the development of 3D melanoma models using different cell lines. ...

Reference:

Biobased hydrogel bioinks of pectin, nanocellulose and lysozyme nanofibrils for the bioprinting of A375 melanoma cell-laden 3D in vitro platforms

... This has also been shown to decrease the levels of the inflammatory cytokines IL-1β and TNF-α in mice fed a high-fat diet. This activity suppressed proinflammatory NF-κB signaling and increased the antiinflammatory action of Nrf-2/HO-1 in the hippocampus (Yang et al. 2019), (Kumar Dhritlahre et al. 2024). ...

Reference:

Formononetin: pharmacological properties and therapeutic potential

... The FTIR spectra of all the samples are shown in Figure 2. The characteristic peaks of the FTIR spectra of PT are as follows: 3272 cm −1 (-OH bond stretching vibration peak), 2928 cm −1 (-CH 2 -asymmetric stretching vibration peak), 1606 cm −1, 1573 cm −1 ,1513 cm −1 , and 1473 cm −1 (C═C stretching vibration peak in aromatic ring skeleton; Chhimwal et al., 2023). In the FTIR spectra of PT NEs and PT-VE-NEs, some peaks of PT appeared. ...

Reference:

The synergistic effect of α‐tocopherol and phloretin‐loaded nanoemulsions on improvement of the stability, antioxidant, and tyrosinase inhibitory potentiality

... COFs consist well-defined and lightweight elements such as hydrogen (H), carbon (C), nitrogen (N), oxygen (O), and boron (B), possess electron-rich groups, a large surface area and highly stable structures, rendering them excellent reservoirs with ultrahigh loading ratios (Khan et al. 2023). As a result, they have been employed to effectively deliver different types of functional agents, including anti-cancer drugs, small interfering RNAs (siRNAs), radiosensitizers, sonosensitizers, photosensitizers, and small molecule inhibitors to the tumor site via the systemic route. ...

Reference:

Covalent organic frameworks in cancer theranostics: advancing biomarker detection and tumor-targeted therapy

... The chitosan powder exhibited a semicrystalline state, and the diffractogram of chitosan presented an almost halo pattern [77]. The PXRD pattern of ascorbic acid demonstrated that it is a crystalline substance, as evidenced by multiple sharp diffraction peaks that correspond to the crystalline diffraction lines described in the literature [78]. According to the diffractogram of metronidazole, the multiple sharp reflections reflected the crystalline form of the drug. ...

Reference:

Box-Behnken Design Assisted Optimization and Characterization of Chitosan Film for Simultaneous Topical Delivery of Ascorbic Acid and Metronidazole

... Therefore, there is an eagerness to develop a scientific method for the envelope material feasibility to provide scientific guidance. Recent advances in silico techniques have resulted in more powerful methods to analyze the host-guest interactions of IC, for example, molecular docking [34], molecular dynamic (MD) simulations [35], and umbrella sampling simulations [28], etc. Molecular docking provides information about the interactions between CDs and guest sites [17]. ...

Reference:

New insights into the influence of encapsulation materials on the feasibility of ultrasonic-assisted encapsulation of Mosla chinensis essential oil

... In a rodent model of epilepsy induced by pentylenetetrazol via an Nrf2 pathway, treatment with ALA improved behavioral dysfunction and significantly reduced the number of epileptic seizures . Unfortunately, as a drug candidate, ALA has poor pharmacokinetic properties that limit its therapeutic potential (Kumari et al., 2022;Salehi et al., 2019;Steliou et al., 2015;Usacheva et al., 2022). Ongoing efforts in design and chemical synthesis aim to overcome these deficiencies using ALA prodrugs prepared from analogues, derivatives or conjugates as potential therapeutics with more favorable pharmacological properties (Javaid et al., 2022;Kong et al., 2022;Kumari et al., 2022;Lv et al., 2022;Moos et al., 2022;Steliou et al., 2015;Wang et al., 2020;Zielonka et al., 2017). ...

Reference:

Epilepsy: Mitochondrial Connections to the ‘Sacred’ Disease

... Among current antitumor treatments, chemotherapy plays an essential role, but most chemical agents have low specificity for cancer cells, resulting in toxicity and side effects in the body [2]. To overcome these obstacles, many studies have focused on tumorspecific targeting systems, which are expected to play an important role in the next generation of chemotherapy treatments [3,4]. ...

Reference:

Advancing Breast Cancer Therapeutics: Targeted Gene Delivery Systems Unveiling the Potential of Estrogen Receptor-Targeting Ligands