Anjana Ray's research while affiliated with Brigham and Women's Hospital and other places
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Publications (4)
Objective
The risk of thrombosis in myeloproliferative neoplasms, such as primary myelofibrosis varies depending on the type of key driving mutation (JAK2 [janus kinase 2], CALR [calreticulin], and MPL [myeloproliferative leukemia protein or thrombopoietin receptor]) and the accompanying mutations in other genes. In the current study, we sought to...
Background
The mechanisms that regulate platelet biogenesis remain unclear; factors that trigger megakaryocytes (MKs) to initiate platelet production are poorly understood. Platelet formation begins with proplatelets which are cellular extensions originating from the MK cell body.
Objectives
Proplatelet formation is an asynchronous and dynamic pro...
Extracellular vesicles (EVs) are lipid bilayered compartments released by virtually all living cells, including fungi. Among the diverse molecules carried by fungal EVs, a number of immunogens, virulence factors and regulators have been characterized. Within EVs, these components could potentially impact disease outcomes by interacting with the hos...
Platelets are specialized anucleate cells that circulate in the blood and serve to prevent bleeding and minimize blood vessel injury. In addition to their hemostatic functions, platelets participate in wound healing, angiogenesis, inflammation, and immunity, and are therefore central players in both maintaining normal physiology and in disease path...
Citations
... A study reported abnormalities in arachidonic acid metabolism [20], which is consistent with our results that showed decreased aggregation in MPN platelets after activation with arachidonic acid. Recently, a study also revealed platelet dysfunction in JAK2 V617F transgenic mice [22]. ...
... 4 In our recent work, we have focused on cell surface area, perimeter, circularity (FormFactor), pseudopodia (endpoint) number, and total pseudopodia length. 1 Examples of the processing steps from which these outputs are measured are seen in Figure 2. Cell morphology characteristics have been shown to change under various conditions, such as chronic stress. 1 Protocols similar to this have also been used in other biological contexts and cell types, demonstrating the broad applicability of quantifying cell morphology. 8,9 Cell morphology phenotypes can be indicative of organism characteristics; for example, differences in cell morphology have been associated with donor age more closely than other established biomolecular measurements such as DNA damage response or adenosine triphosphate content. 10 ...
... We see the discovery of fungal extracellular vesicles as a direct consequence of the unique views of Professor Travassos, who foresaw the possibility that fungal lipids could be transitory cell wall components participating in exportation events in fungal cells. Fungal EVs are now candidates for vaccine development [21][22][23][24], which connects a fundamental discovery with a clearly translational potential. ...