Angsuman Das Chaudhuri’s research while affiliated with Vidyasagar University and other places

Breast cancer is a global health burden and therefore necessitates a continued exploration for new therapeutic mediators. In current scenario, nanotechnology has developed an interest in the application of nanoparticles in treating cancer. The need for new therapeutic agents against one of the global health burdens, breast cancer, is continuous. Nanoparticle application using nanotechnology for cancers has received increased interest in recent years. This review critically analyzes the bioactive compounds of Anacardium occidentale, commonly known as cashew, and their synthesized nanoparticles in relation to activities on cell lines responsible for breast cancer. These facts describe the phytochemical make-up of Anacardium occidentale's, approaches for nanoparticles synthesis, and their modes of action with respect to tumor cells; and implications for the elaboration of future approaches to the treatment of cancer.

This present investigation focuses on the fact that nanoformulation of phytochemicals could enhance the therapeutic capacity in different physiological systems by enhancing hydrophilicity and bioavailability. In this study gelatin nano-formulation of benzyl isothiocyanate (BITC) was prepared and characterized by dynamic light scattering and UV-Visible spectrometry. Then antioxidant activity of BITC and BITC-gelatin NPs was determined in different concentrations through measuring 2,2- diphenyl-1- picrylhydrazyl (DPPH), superoxide, hydroxyl radical, nitric oxide scavenging and lipid peroxidation inhibition activities. DLS and UV-Vis study revealed the production of uniform nanosized particles and effective encapsulation of BITC respectively. The results of antioxidant assays suggested that BITC-gelatin NPs more effectively scavenged free radicals and inhibited lipid peroxidation compared to free BITC. The findings proposed that gelatin formulated BITC nanoparticles could be effective against oxidative stress related disorders.

Geraniol, a naturally occurring monoterpenoid found in essential oils of several aromatic plants, exhibits numerous therapeutic properties, including anti-inflammatory, antimicrobial, and anticancer activities. However, its therapeutic potential is hindered by poor water solubility, limited bioavailability, and rapid metabolism. Nanotechnology- based delivery systems offer a promising solution to these challenges, by enhancing the solubility, stability, and bioavailability of geraniol through advanced delivery systems in cancer treatment. This review critically examines recent advances in nanotechnology- based delivery systems for geraniol, exploring various nanocarriers such as liposomes, polymeric nanoparticles, dendrimers, and solid lipid nanoparticles. The review also highlights the mechanisms by which these nanocarriers improve geraniol's pharmacokinetic profile, its targeted delivery to cancer cells, and its impact on overcoming multidrug resistance. Future perspectives and potential clinical applications are discussed, emphasizing the need for further research to fully harness the potential of geraniol in cancer therapy.

Geraniol, a naturally occurring monoterpenoid found in essential oils of several aromatic plants, exhibits numerous therapeutic properties, including anti-inflammatory, antimicrobial, and anticancer activities. However, its therapeutic potential is hindered by poor water solubility, limited bioavailability, and rapid metabolism. Nanotechnology-based delivery systems offer a promising solution to these challenges, by enhancing the solubility, stability, and bioavailability of geraniol through advanced delivery systems in cancer treatment. This review critically examines recent advances in nanotechnology-based delivery systems for geraniol, exploring various nanocarriers such as liposomes, polymeric nanoparticles, dendrimers, and solid lipid nanoparticles. The review also highlights the mechanisms by which these nanocarriers improve geraniol's pharmacokinetic profile, its targeted delivery to cancer cells, and its impact on overcoming multidrug resistance. Future perspectives and potential clinical applications are discussed, emphasizing the need for further research to fully harness the potential of geraniol in cancer therapy.

Hesperetin (HSP) is a natural bioflavonoid found abundantly in citrus fruits with promising antioxidant, anti-inflammatory, anti-hypertensive andanti-cancer properties. The aim of the present study was to evaluate the in vivoanticancer activityof synthesized HSP loaded PLGA nanoparticles (PLGA-HSP NPs) in Ehrlich Ascites Carcinoma (EAC) cell bearing Swiss albino miceusing the standard drug 5-fluorouracil. PLGA-HSP NPs led to a considerable reduction in tumor volume, the number of viable tumor cells, and body weight in EAC tumor-bearing mice, as well as an increase in the mean survival time. PLGA-HSP NPs protect the host tissues from oxidative stress by recovering the antioxidant status in host mice. PLGA-HSP NPs also restored the haematological parameters. The aforementioned finding revealed that PLGA-HSP NPs have a favourable impact on EAC cell bearing Swiss albino mice. Therefore, the findings of the present study indicate that PLGA-HSP NPs may be considered as a competent anticancer agent in future.