Angela Leung's research while affiliated with Beth Israel Deaconess Medical Center and other places

Publications (8)

Article
Research Question : What is the clinical experience of patients who have undergone planned oocyte cryopreservation (OC) and thaw? Design : Retrospective observational cohort study. All female patients who completed planned OC at a single large university-affiliated fertility center from June 2006 to October 2020 were identified, including the subs...
Article
Objective To determine how a shift in clinical practice along with laboratory changes has impacted singleton perinatal outcomes after autologous in vitro fertilization (IVF) cycles. Design Retrospective cohort. Setting Single academic fertility clinic. Patient(s) Singleton live births resulting from all IVF cycles (n = 14,424) from August 1, 199...
Article
STUDY QUESTION What are the cohort trends of women undergoing oocyte cryopreservation (OC)? SUMMARY ANSWER There has been a dramatic increase in OC cycles undertaken each year since 2010, and the demographics of women accessing OC has shifted to a younger age group, but so far very few women have returned to use their cryopreserved oocytes in trea...
Article
Research question: Day of cryopreservation, inner cell mass (ICM) grade, trophectoderm grade and blastocyst expansion grade have been associated with differences in live birth rate in frozen embryo transfer (FET) cycles. This study sought to examine the likelihood of live birth and whether the morphological grade of the blastocyst is more or equal...
Article
Objective: To investigate assisted reproductive technology (ART) outcomes in a female-to-male transgender cohort and compare the results with those of a matched cisgender cohort. Design: Matched retrospective cohort study. Setting: In vitro fertilization clinic. Patient(s): Female-to-male transgender patients (n = 26) who sought care from 20...
Article
Objective: To study how many infertility patients would complete an average-sized family (achieve ≥2 live births) after a single, complete in vitro fertilization (IVF) cycle. Design: A retrospective cohort study. Setting: University-affiliated private infertility practice. Patient(s): Women undergoing IVF. Intervention(s): None. Main outc...

Citations

... Social freezing, where autologous oocytes are collected and cryopreserved at a younger age for potential future use, is increasingly used as an option to negate the risk of age-related fertility loss [13]. In a recent retrospective US study of 921 women who vitrified their oocytes between 2006 and 2020, women who cryopreserved their oocytes before aged 38 achieved a higher cumulative live birth rate (CLBR) (38.9%) than those who planned their oocytes cryopreservation after age 38 (25%) [14]. This is also shown in a previous study by Cobo and colleagues who reported CLBR increased for every additional oocytes in women below 36 years old but this reached a plateau for older women ≥ age 36 [15]. ...
... For example, a recent study investigated the perinatal outcomes of singleton births resulting from fresh and frozen transfers in a single US-based academic center over a 24-year period [7]. Their study included 9280 singletons from fresh transfers, including vanishing twins, and reported the unadjusted mean (SD) birthweight 3275 ± 605 g, mean gestational age 38.4 ± 2.1 weeks, 15.6% preterm delivery (PTD) rate, 7.3% small for gestational age, and 10.5% large for gestational age. ...
... Social freezing, where autologous oocytes are collected and cryopreserved at a younger age for potential future use, is increasingly used as an option to negate the risk of age-related fertility loss [13]. In a recent retrospective US study of 921 women who vitrified their oocytes between 2006 and 2020, women who cryopreserved their oocytes before aged 38 achieved a higher cumulative live birth rate (CLBR) (38.9%) than those who planned their oocytes cryopreservation after age 38 (25%) [14]. ...
... Our regression analysis did not find the day of embryo biopsy or the embryo quality to be independent factors for any of the outcomes, but their interaction was predicting pregnancy, clinical pregnancy and live birth rate. This is consistent with other studies suggesting that embryos biopsied on day 5 have better live birth rates compared to embryos biopsied on day 6 [25,[27][28][29] and that blastocyst morphology [27][28][29][30][31][32] and blastocyst expansion [29] are significant factors affecting live birth. ...
... Moreover, a retrospective study involving 26 transgender men showed promising fertility preservation outcomes with a mean of 20 oocytes retrieved. Among the enrolled patients, seven patients had their embryos transferred, followed by a successful pregnancy [25]. During fertility preservation counseling, a major issue is planning for the gestational carrier and future embryo. ...
... The fact that none of the aforementioned parameters was observed to be indicative of the fertilization or cleavage rate is in accordance to literature. It has been observed that AFC, E 2 , AMH, FSH or LH should not be employed as predictive factors regarding either fertilization or cleavage rate 44,[47][48][49][50] . Only prolactin levels have been reported in literature to be predictive of fertilization and cleavage rate, with a cut-off value of 16.05 ng/ mL 50 . ...
... Given that oocyte cryopreservation requires discontinuation of testosterone therapy for varying lengths of time before starting ovarian stimulation (OS) (ranging from 1 to 12 months according to previous studies), almost all transgender men will experience menses, usually within 3 months of stopping testosterone, and this can cause gender dysphoria [27][28][29][30][31][32]. Moreover, in these cases, the increase of oestrogen levels during OS can cause mental distress and adversely affected the view of their bodies [33,34]. ...
... Recent studies have found that the live birth rate in fresh cycles increases with an increasing number of retrieved oocytes, with a plateau occurring when the number of retrieved oocytes reaches 15 or more, and the cumulative live birth rates for both fresh and frozen cycles consistently increase with an increasing number of retrieved oocytes, without a plateau (40,(43)(44)(45). The incidence of severe OHSS also increases with an increasing number of retrieved oocytes, especially when the number of retrieved oocytes reaches 18 and above, and the incidence of thromboembolism also increases significantly when the number of retrieved oocytes is more than 15 (46). ...