Andy Yu's research while affiliated with Harvard Medical School and other places

Publications (4)

Article
Full-text available
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an...
Article
Introduction: Peripartum cardiomyopathy (PPCM) is a rare form of pregnancy-related heart failure associated with preeclampsia. Our understanding of their shared pathophysiology is limited as are treatment options. Hypothesis: We hypothesized that plasma proteomic profiling would identify deleterious circulating proteins and provide insights into sh...
Preprint
Full-text available
Cardiovascular complications are common in COVID-19 and strongly associated with disease severity and mortality. However, the mechanisms driving cardiac injury and failure in COVID-19 are largely unknown. We performed plasma proteomics on 80 COVID-19 patients and controls, grouped according to disease severity and cardiac involvement. Findings were...
Article
Full-text available
Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most effective intervention to improving functional outcomes in this age‐related disease. The molecular mechanisms by which ExT induc...

Citations

... Multiple factors likely contribute to cardiac injury and dysfunction in COVID-19 [9]. It seems that the occurrence of COVID-19-induced myocardial damage is a multifaceted pathophysiological process that includes interplay between oxidative distress, inflammation, endothelial dysfunction and thrombosis as the major underlying mechanisms [10][11][12]. ...
... In contrast, proinflammatory pathways of IL6, IL1, and TNFA signaling were not increased in Ad26.COV2.S vaccinated macaques (Fig 4B). Further, proteomics analysis showed that pathways of thrombosis and markers upregulated in plasma from severe COVID-19 patients [26] were upregulated in sham macaques challenged with WA1/2020 or B.1.351 variant but were unchanged in vaccinated animals (Fig 4B). ...
... Several potential mechanisms might underlie the observed relations between a healthy lifestyle and HF. Animal studies have shown that exercise training (ExT) can reverse cardiac aging phenotypes associated with heart failure with preserved ejection fraction (HfpEF) in male mice, and its molecular mechanism involves that ExT reversing the downregulation of fatty acid metabolism pathways related to aging and ultimately regulating the cell cycle and cell division [49]. Other animal studies in mice have also shown that the improvement of heart failure by exercise is related to the recovery of oxidative metabolism [50], the β3-AR-nNOS-NO pathway [51], autonomic imbalance, and impaired calcium homeostasis [52]. ...