Andrew Yeomans’s scientific contributions

Intensive studies on acid-base balance of the blood have been made on four patients with renal disease and two patients with respiratory disease. Applying the concepts of Singer and Hastings, the data have been interpreted in terms of the two physiologically important variables, namely, the whole blood buffer base and CO2 tension. The clinical value of this simplified method of interpretation has been demonstrated. The whole blood buffer base is the metabolic component and the CO2 tension the respiratory component of the acid-base balance of the blood. In these studies a primary increase or decrease in one variable was followed with a secondary increase or decrease in the other. When the secondary response was not sufficient to re-establish normal equilibrium between the two variables, a shift in pH occurred.