Andrés Vicente-Acosta's research while affiliated with Universidad Autónoma de Madrid and other places

Publications (3)

Article
Friedreich’s ataxia (FRDA) is predominantly a neurodegenerative disease caused by the deficiency of a protein called frataxin (FXN). Although the main pathological alterations are observed in neurons, it is becoming clear that other non-neuronal cells such as astrocytes may be actively involved in the neurodegenerative process associated with the d...
Article
Full-text available
Stroke is the second leading cause of death worldwide following coronary heart disease. Despite significant efforts to find effective treatments to reduce neurological damage, many patients suffer from sequelae that impair their quality of life. For this reason, the search for new therapeutic options for the treatment of these patients is a priorit...
Article
Full-text available
Background Friedreich’s ataxia is a rare hereditary neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Similar to other neurodegenerative pathologies, previous studies suggested that astrocytes might contribute to the progression of the disease. To fully understand the mechanisms underlying neurodegeneration...

Citations

... increased COX2 [41] YG8R mice Increased satellite cell proliferation, astrocytosis and influx of OX42 positive cells in the spinal cord and cerebellum [42] FGKO mice Severe ataxia after frataxin deletion in astrocytes during development [43] Microglial cell lines Increased DNA damage after frataxin knockdown [40] Mouse primary astrocytes Increased ROS production after frataxin knockdown [44] Human astrocytes in vitro Impaired mitochondrial activity and superoxide formation; increased release of inflammatory molecules and toxicity for neurons after frataxin knockdown [45,46] iPSC-derived YG8R astrocytes ...