Andrés C. A. Culasso's research while affiliated with Universidad de Buenos Aires and other places

... Year Authors Summary points 2023 Torres, et al., [56] The dynamics of the third and fourth waves of variants of the Omicron strain of CVID-19 in ARG are studied, based on phylogenetic and phylodynamic sequencing analyses, concluding that the different propagation dynamics would be due to various factors such as decreased immunity and increased population reinforced with vaccination or immunity to previous strains. 2023 Zhao, et al., [57] This article investigates the relationship between the acceptance of the COVID-19 vaccine by people with chronic diseases and the factors that correlate with their disagreement with vaccination. ...

... PV infection in NWP is scarcer, with reports in asymptomatic captive marmosets, squirrel monkeys, howler monkeys, spider monkeys and titi monkeys (37,47,199). In wildlife PV was detected by PCR in oral swabs of two freeranging NWP, one capuchin and one howler monkey, both from Argentina (176). HPV was investigated by IHC in a case of multicentric cutaneous keratoacanthomas in a freeranging marmoset, but no viral antigen was detected (49). ...

... In addition, as expected, they exhibited a marked nucleotide divergence with other described HEV-3 subtypes. Altogether, all these findings support previous data that suggested that HEV had a recent introduction in Uruguay and likely from a single geographic origin [42], which is in sharp contrast to other South American countries [43,44] Significant research efforts have been made to obtain additional complete genomes from Uruguay through different enrichment methods, but the low HEV titers in the sample and the lack of an efficient cell culture system have severely hampered the results. ...

... HAdVs are classified into seven species (A-G) as mentioned above. Within each species, HAdV are subclassified into serotypes and/or genotypes [62]. The initial 51 serotypes were determined by neutralization assays or complement fixation assays, while genotypes 52 onwards were described by bioinformatic analysis of whole genome sequences [63,64]. ...

... Given global efforts towards early diagnosis and immediate or rapid ART initiation [50], studies examining in vivo HIV evolution in the absence of ART have become challenging [51][52][53]. ...

... In this study, 29 samples from women with squamous intraepithelial lesions and cervical cancer were studied: 6 ASCUS (Atypical squamous cells of undetermined significance), 3 LSIL (low-grade squamous intraepithelial lesion), 12 HSIL (high-grade squamous intraepithelial lesion) and 7 CC (cervical cancer) attending six community health centers from the Coastal region of Ecuador between 2012-2015 were available for sequencing, including the localities of Esmeraldas (n = 4), Guayas (n = 14), Santa Elena (n = 1), El Oro (n = 1), Los Rios (n = 4), and Manabí (n = 5). All patients had previous results corresponding to HPV16 infection, as described by Bedoya-Pilozo et al., 2018 [20]. This study was approved by the Bioethics Committee (Hospital "Francisco Icaza Bustamente", Ministry of Public Health). ...

... Despite the approval and availability of anti-NS3/4A, anti-NS5A, and anti-NS5B inhibitors for the treatment of HCV infections, naturally occurring polymorphisms (mutations) in target proteins for DAAs have been a major concern [40][41][42]. In recent years, DAAs have enhanced the sustained virologic response (SVR) rate remarkably [43]; however, due to the high replication rate and low fidelity of the HCV-RdRp enzyme, the evolution of the heterogeneous virus populations that are resistant to DAAs remains a major challenge [41]. ...

... However, other regions such as NS3 as an alternative candidate were taken into account by some other groups. As a candidate gene for genotyping purpose, it even showed a comparable sensitivity and specificity level with commercially available Versant HCV 2.0 reverse hybridization lineprobe assay (LiPA 2.0) for subtyping assay (Neukam et al., 2017). In our experiment, it was also revealed that NS3 protease region exhibits a reliable discriminative potential to differentiate between sub-genotype 1a, 1b, and 3a. ...

... [17] As a result, we clarified for the first time that DAA-resistant HCV consisted of resistant virus haplotypes, quasispecies with various HASs, and changed over time during the treatment with different RASs. This indicates that resistance to DAA, [6] growth fitness in the host, [26] and the ability to escape from the immune reaction are different depending on the haplotype [27] and not on the simple individual signature mutations of HCV genomes as previously thought. The HCV haplotype may be involved in a pathological process, such as fibrosis or carcinogenesis, caused by persistent infection of HCV. ...

... There was no association between HBV detection and plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Thus, subjects infected with HBV showed ALT 15 IU l −1 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) and AST 17 IU l −1 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23), whereas the corresponding figures among non-HBV infected patients were 15 IU l −1 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) for ALT, and 15 IU l −1 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) and AST 21 IU l −1 (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), whereas the levels for non-HCV infected patients were 14 IU l −1 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20) for ALT and 14 IUl −1 (11)(12)(13)(14)(15)(16)(17)(18)(19) for AST (P <0.001 for both ALT and AST). ...