Andrea Maria Suárez’s research while affiliated with University of Barcelona and other places

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Publications (6)


Nitric Oxide Metabolite Production During Exercise in Chronic Fatigue Syndrome: A Case-Control Study
  • Article

June 2010

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250 Reads

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38 Citations

Journal of Women's Health

Andrea Suárez

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Chronic fatigue syndrome (CFS) is a disabling illness of unknown etiology that is characterized by fatigue associated with a reduced ability to work, lasting for more than 6 months, and accompanied by a specific set of symptoms. The diagnosis remains difficult because of the absence of laboratory tests and is, therefore, made largely on the basis of the symptoms reported by the patient. The aim of this study was to analyze differences in blood nitrate levels in CFS patients and a matched control group after a physical exercise test. Forty-four consecutive female patients with CFS and 25 healthy women performed an exercise test using a cycle ergometer with monitoring of cardiopulmonary response. Blood samples were obtained for biochemical analyses of glucose, lactate, and nitrates at the beginning (under resting conditions) and after the maximal and supramaximal tests. Plasma nitrates differed between the groups, with higher values in the CFS group (F = 6.93, p = 0.003). Nitrate concentration increased in relation to workload and reached higher values in the CFS group, the maximum difference with respect to the control group being 295% (t = 4.88, p < 0.001). The main result of the present study is that nitric oxide (NO) metabolites (nitrates) showed a much higher increase after a maximal physical test in CFS patients than in a group of matched subjects. This combination (exercise plus NO response evaluation) may be useful in the assessment of CFS.


Hormonal evaluation in the Chronic Fatigue syndrome
  • Conference Paper
  • Full-text available

November 2008

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9 Reads

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Diferencias interindividuales en las concentraciones de cortisol plasmático tras una de ejercicio mixto aeróbico-anaeróbico.

December 2007

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47 Reads

Apunts Medicina de l Esport

Introducción y objetivos: El objetivo del estudio fue evaluar las diferencias en la concentración plasmática de cortisol tras la realización de un esfuerzo mixto, aeróbicoanaeróbico, en un grupo de jóvenes físicamente activos. Métodos: Catorce voluntarios realizaron, en un cicloergómetro, 40 min de ejercicio a la intensidad correspondiente al 50% del pico individual de consumo de oxígeno, manteniendo el ritmo de pedaleo a 60 revoluciones/min. Durante el mismo, se intercalaron 4 fases de 30 s con una carga de 0,04 kg por kilo de masa corporal en los minutos 10, 20, 30 y 40. Tras estos primeros minutos, pedaleaban durante 20 min a la máxima velocidad posible frente a una carga constante correspondiente al 50% del consumo de oxígeno. Se controlaron los parámetros cardiorrespiratorios y se recogieron muestras sanguíneas al inicio de la prueba, cada 10 min durante el ejercicio y a los 15 min de la recuperación. Resultados: Las respuestas cardiopulmonar y metabólica fueron muy homogéneas, con un aumento de los valores de cortisol a lo largo de la prueba (F = 5,16; p < 0,001) que presentó diferencias entre los sujetos (F = 6,74; p < 0,001). En 8 participantes (57,1% de la muestra) se observó un aumento, y en 6 (42,9%) los cambios fueron pequeños con respecto a los valores previos al inicio de la prueba. Conclusión: A pesar de haber evaluado un grupo homogéneo, se observaron diferencias interindividuales en la concentración plasmática de cortisol tras la realización de un esfuerzo mixto, lo que puede tener implicaciones en la adaptación provocada por el ejercicio.


Physiological Responses to Arm and Leg Exercise in Women Patients with Chronic Fatigue Syndrome

May 2007

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118 Reads

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11 Citations

Journal of Chronic Fatigue Syndrome

Patients affected by chronic fatigue syndrome (CFS) characteristically show easy and unexplained fatigue after minimal exertion that does not resolve with rest and is associated with specific symptoms lasting for more than six months. Cardiopulmonary exercise testing is a valid procedure for determining functional capacity in patients with CFS. We compare cardioventilatory adaptation to exercise between a group of eighty-five consecutive women patients affected by CFS and a group of fifteen healthy women extremely sedentary individuals, with the use of maximum incremental exercise testing on a cycle ergometer and arm ergometer, assessing possible differences. The majority of values achieved at peak exhaustive exercise were significantly lower in CFS patients than controls, including the percentage of maximum oxygen uptake in arm physical test (37.4±10.0% in CFS vs. 58.9± 15.8% in controls) and leg physical test (53.4±15.0% in CFS patients vs. 76.2 ± 18.0% in controls). In conclusion, the CFS group shows a lower work capacity in arm or leg exercise that would not be justified exclusively by their personal characteristics or deconditioning.


Diferències interindividuals en les concentracions de cortisol plasmàtic després d'una hora d'exercici mixt aeròbic-anaeròbic

January 2007

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28 Reads

Apunts Medicina de l Esport

Introducció i objectius: L’objectiu de l’estudi va ser avaluar les diferències en la concentració plasmàtica de cortisol després de la realització d’un esforç mixt, aeròbic-anaeròbic, en un grup de joves físicament actius. Mètodes: Catorze voluntaris van fer, en un cicloergòmetre, 40 min d’exercici a la intensitat corresponent al 50% del consum màxim d’oxigen, mantenint el ritme de pedalada a 60 revolucions/min. I s’hi van intercalar 4 fases de 30 s amb una càrrega de 0,04 kg per quilo de massa corporal, en els minuts 10, 20, 30 i 40. Després d’aquests primers minuts, pedalaven durant 20 min a la màxima velocitat possible per una càrrega constant corresponent al 50% del consum màxim d’oxigen. Se’n van monitoritzar els paràmetres cardiorespiratoris, i se’n recolliren mostres sanguínies a l’inici de la prova, cada 10 min durant l’exercici i als 15 min de la recuperació. Resultats: Les respostes cardiopulmonar i metabòlica van ser molt homogènies, amb un augment dels valors de cortisol durant la prova (F = 5,16; p < 0,001), que van presentar diferències entre els subjectes (F = 6,74; p < 0,001). En 8 participants (57,1% de la mostra) es va observar un augment, i en 6 (42,9% de la mostra) els canvis van ser petits respecte dels valors previs a l’inici de la prova. Conclusió: Malgrat ser avaluat un grup homogeni, es van observar diferències interindividuals en la concentració plasmàtica de cortisol després de la realització d’un esforç mixt, que poden tenir implicacions en l’adaptació provocada per l’exercici.


Response to Exercise in Paraplegics and Able Bodied Subjects: A New Formula to Estimate the Theoretical Oxygen Uptake

August 2006

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66 Reads

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1 Citation

Journal of Sport Rehabilitation

Purpose To compare the response to physical exercise between subjects with spinal cord injury (SCI) and able-bodied (AB) subjects with the objective of developing a new formula for the indirect calculation of oxygen consumption (VO 2 ). Subjects 20 individuals with paraplegia below Th 6 and 22 AB subjects have participated in the study. Measures A graded work test was performed on an arm ergometer, starting with 10 w and increasing the power in 10 w each minute up to maximal effort. SCI group present a lower response to the different workloads with respect to the AB group. Results In the SCI group, a statistical association was found between workload and VO 2 (r = 0.956, P < 0.001). The proposed equation to calculate the theoretical VO 2 was the following: 0.487 + (0.013 · watts performed). Conclusions SCI males, respect to AB subjects, show differences in ventilatory response to exercises. We propose a new formula for the indirect calculation of VO 2 in relation to workload.

Citations (2)


... To counter adverse changes in the body's functions and maintain athletic performance, it's crucial to address violations of training and rest schedules and provide athletes with additional rest. Failing to adhere to these measures can result in the development of chronic fatigue syndrome [11]. This is supported by numerous studies demonstrating that in high-level athletes, the emergence of acute and chronic fatigue under prolonged, intensive physical and psychological stress can lead to chronic fatigue syndrome [12,13]. ...

Reference:

Prevalence of chronic fatigue and chronic fatigue syndrome in ukrainian elite athletes: results from a population-based study.
Physiological Responses to Arm and Leg Exercise in Women Patients with Chronic Fatigue Syndrome

Journal of Chronic Fatigue Syndrome

... Positive studies: increased levels of inducible nitric oxide synthase (iNOS), nitric oxide (NO), peroxynitrite, and nitrate (427)(428)(429). Increased nitrosative stress is further augmented by exercise (430), and may be secondary to increased production of NFκB (431) and impaired autophagy (432). Positive studies: reduced on initial CPET (180), and worsened when CPET is repeated 24 h later (440,441), as confirmed by several meta-analyses (442)(443)(444). ...

Nitric Oxide Metabolite Production During Exercise in Chronic Fatigue Syndrome: A Case-Control Study
  • Citing Article
  • June 2010

Journal of Women's Health