André Magalhães's research while affiliated with Centro Hospitalar de São João and other places

Publications (22)

Article
Full-text available
Purpose In breast cancer management not only mortality and surgical morbidity measurements are important but also patient satisfaction indexes. The authors evaluated the satisfaction and health-related quality of life (HRQOL) using the breast-conserving therapy (BCT) and breast reduction (BR) modules of BREAST-Q®. Methods This is a cross-sectional...
Article
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Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and proces...
Article
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Background: Targeted axillary dissection (TAD) combines sentinel node biopsy (SNB) with the removal of the previously marked metastatic node. TAD is a promising concept for axillary restaging in node-positive breast cancer patients with pathological complete response (pCR) to neoadjuvant therapy (NAT). We aimed to evaluate TAD feasibility in this...
Article
Full-text available
Introduction: Breast cancer is the most incident cancer in the world, accounting for 25% of new cancers per year in females. It is the most frequent malignancy in women, being the fifth cause of death from cancer worldwide. Approximately 5 to 10% of patients already present with metastases at diagnosis, and the liver is the site of metastases in h...
Article
Full-text available
Hereditary diffuse gastric cancer (HDGC) caused by CDH1 variants predisposes to early-onset diffuse gastric (DGC) and lobular breast cancer (LBC). In Northern Portugal, the unusually high number of HDGC cases in unrelated families carrying the c.1901C>T variant (formerly known as p.A634V) suggested this as a CDH1-founder variant. We aimed to demons...
Poster
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Introdução: A cirurgia oncológica da mama apresenta uma taxa de morbilidade importante que não deve ser menosprezada. O objetivo do nosso trabalho foi determinar os fatores de risco para complicações cirúrgicas após cirurgia oncológica mamária. Métodos: Estudo retrospetivo, unicêntrico e transversal de doentes submetidas a cirurgia por cancro da ma...
Article
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Background 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on...
Article
Full-text available
p>Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications...
Article
OSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and completion AD. Logistic regression models were per...
Presentation
Introducción – O Síndrome de Cancro Gástrico Difuso Hereditario (CGDH) apresenta uma hereditariedade autossómica dominante, atribuida a mutações germinativas do gene CDH1, apresentando uma elevada penetrância histológica. As mulheres portadoras apresentam, simultaneamente, um risco ao longo da vida de até 68% de Carcinoma Lobular Invasor (CLI) da M...
Article
Full-text available
Introduction: Treatment of metastatic breast cancer (BC) has undergone considerable changes and recent advances in systemic therapies significantly increased survival. Regarding liver metastasis (LM), selected patients may benefit from combining systemic with liver-directed therapies, namely resection. With the benefits demonstrated after resection...
Article
The need to perform an Axillary Dissection when the Sentinel Node is metastasized, in Breast Cancer patients, is being questioned. Most part of the patients do not have any additional metastasis in the Non Sentinel Nodes and, in many cases, the decision to perform adjuvant treatments is not dependent on the axillary nodes analysis. The recent publi...

Citations

... 3 Mortality is higher following surgery in low-income and middleincome countries than in high-income countries. [4][5][6] The African Surgical Outcomes Study (ASOS) showed that the risk of mortality following surgery in patients across Africa was twice as high as the global average. 4 Most deaths in Africa occur on hospital wards after surgery, suggesting that many lives could be saved through the early identification of postoperative physiological deterioration in surgical patients. ...
... Malignancies can occur in almost all soft organs and glands such as skin, liver, brain, lungs and kidneys as well as those connective tissues including muscles, fat and ligaments [63][64][65]. Surgery is the primary treatment for most of these tumor indications in clinical practice for both curative and palliative purposes [66][67][68]. However, it is well-established that tumors are highly invasive and some microscopic tumors would inevitably remain in the postoperative wound despite maximum safe resection, which may act as seeds to initiate both local relapse and distant metastasis [69,70]. ...
... Similarly to breast cancer, the total tumor load (TTL), defined as the amount of CK19 mRNA copy numbers in all positive SLNs (copies/µL), could also be a relevant prognostic factor in PCa. In breast cancer, a relationship between TTL and the presence of additional non-SLN metastases and correlation with a higher risk of recurrence could be shown [37][38][39]. In the future, the TTL could also be used in PCa and, for example, improve the management of adjuvant therapy. ...
... Ki67 expression decreased as the patient's age increased, demonstrating that lower the Ki67 expression and the tumor is less invasive in older patients. This result was consistent with the results obtained by Vasseur et al, 10 who found Ki67 expression to be higher in younger patients compared with older patients. Tumour size measured both clinically and by ultrasonography, since accuracy was found more with USG, highest measurement on ultrasound was taken for study, tumors were between 1.6 to 10cms in size in its greatest dimension and most were between 3 to 6 cms. ...