Anastasia Dimakopoulou's research while affiliated with Ealing, Hammersmith & West London College and other places

Publications (11)

Article
Androgen therapy is the mainstay of treatment in female to male (FtM) transgender persons to increase testosterone levels, suppress oestrogens and treat gender dysphoria. Testosterone is widely used for male hypogonadism, but is comparatively under-investigated in FtM transgender persons. The aim of our study was to identify treatment and safety ou...
Article
Objectives Functional hypothalamic amenorrhoea (FHA) is a common cause of amenorrhoea, but diagnosis can be challenging. The aim of this study was to investigate the clinical and biochemical features of FHA, compared to that of polycystic ovarian syndrome (PCOS) and assess the diagnostic performance of the different parameters for differentiating t...
Article
Tamoxifen is a selective oestrogen receptor modulator (SERM). SERMs act on oestrogen receptors to inhibit oestradiol mediated negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis, thereby upregulating gonadotrophin secretion and release from the pituitary. Hence, Tamoxifen is used to upregulate activation of the HPG axis in the treatm...
Article
Background: Idiopathic recurrent pregnancy loss (RPL) is the loss of three or more consecutive pregnancies prior to 20 weeks of gestation. Female factors in RPL are well known, but the influence of sperm function on RPL has been poorly understood. Recent studies demonstrate that male partners of women with RPL have higher risk of DNA fragmentation,...
Article
Background: Recurrent pregnancy loss, (RPL) affecting 1%-2% of couples, is defined as ≥3 consecutive pregnancy losses before 20-week' gestation. Women with RPL are routinely screened for etiological factors, but routine screening of male partners is not currently recommended. Recently it has been suggested that sperm quality is reduced in male par...
Article
Background Sperm cryopreservation (freezing) should be offered to all men with cancer due to risk of infertility. However, many men with cancer already have impaired spermatogenesis prior to sperm cryopreservation. Furthermore, physical ill‐health may hinder attendance of freeze visits. Investigating both the distribution of sperm function and free...
Article
Infertility is defined as a failure to achieve a positive pregnancy test over 12 months of regular unprotected sex. It is a devastating condition affecting 15% of couples and is socially marginalizing. Despite significant focus on the female, nearly half of cases are in fact due to poor sperm function in the male partner. It is therefore surprising...

Citations

... This discrepancy could be explained by the fact that the animals in this study were fed a diet containing tamoxifen for 3-weeks; tamoxifen being a potent modulator of gonadal steroid receptors leading to confounding effects on the activity of the gonadotropic axis. In particular, tamoxifen has been clinically shown to increase androgen levels and sperm concentration in males with idiopathic oligozoospermia (72). ...
... [16][17][18][19] In postmenopausal women, testosterone may be used, but further studies are needed to determine long-term safety. [20][21][22] Nonpharmacological approaches to HSDD, including psychotherapy, have shown promising results. 23,24 Many psychotherapy techniques have proved to be valid for the treatment of HSDD, such as Masters and Johnson's sensate focus, 25,26 couple therapy, 27-29 mindfulness, 30,31 and Cognitive-Behavior Therapy (CBT), 32,33 which seem promising in the treatment of menopausal symptoms, 34 genito-pelvic pain, 35 and interpersonal relationship problems. ...
... As the elderly suffer from chronic diseases, they also suffer from CHF and diabetes. Most studies show that the rate of cognitive impairment is as high as 75%-80% [18]. 25%-75% of CHF patients have serious cognitive impairment, which seriously threatens the quality of life of the elderly, resulting in lower compliance and lower self-care ability. ...
... Anetor et al. [69] have provided evidence of the depressing antioxidant status and pathologic correlates in pregnant women on Fe supplement, corroborating the promise and benefit of including markers of oxidative stress in traditional profiles in clinical chemistry. Jayasena et al. [70] have provided evidence of reduced testicular steroidogenesis and increased semen oxidative stress in male partners as novel markers of recurrent miscarriage. ese investigators raised the possibility of seminal ROS measurement as diagnostic and therapeutic in couples with recurrent pregnancy loss. ...
... In practice, a few cancer patients visiting our unit give up sperm preservation owing to the cost. We concluded that the urgent treatment time A study showed that sperm total motile count (TMC) < 1 million was the second most prevalent category of sperm quality among leukaemia patients during the first visit for semen collection [22]. It is imperative to communicate with clinicians in a timely manner to ensure that leukaemia patients bank sperms before cancer treatment. ...