Anand S Irpati’s research while affiliated with Post Graduate Institute of Medical Education and Research and other places

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Publications (5)


Distress due to lithium-induced polyuria: Exploratory study
  • Article
  • Full-text available

June 2011

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87 Reads

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8 Citations

Psychiatry and Clinical Neurosciences

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Anand S Irpati

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Lithium-induced polyuria, although common, often goes unrecognized. The purpose of the present study was therefore to investigate the complaints of polyuria, and distress and functional impairment associated with polyuria, in 56 patients with bipolar disorder on long-term lithium treatment. All participants underwent 24-h urine collection, and renal function tests. Polyuria (24-h urine volume > 3 L) was found in 70% of subjects. Unless directly enquired about, polyuria was underreported. Impairment in work and daily routine due to increased urine output/frequency was associated with 24-h urine volumes. Polyuria is a highly prevalent, distressing and impairing side-effect of long-term lithium treatment, requiring due attention.

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Drug Dependence in the Geriatric Age Group: A Clinic Based Study

January 2008

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67 Reads

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18 Citations

German Journal of Psychiatry

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Anand S. Irpati

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This research aimed to study the demographic and clinical profile of elderly subjects (≥ 60 years) presenting to a state- funded drug addiction centre in northern India. Out of 80 elderly subjects registered with the Centre during 1978- 2003, 63 subjects who were diagnosed by qualified psychiatrists to have substance dependence as per the ICD- 9/ICD-10 and for whom complete case records were available were taken up for the study. A steady rise from 1 case per year to 9.5 cases per year was seen over the years. All subjects were male, most were married (81%), poorly edu- cated (60%), still working (58.7%), belonging to low (63.5%) or middle (22.2%) socioeconomic status, and had minimal (52.4%) or poor (07.9%) social support. The prominent substance use related patterns were: alcohol (60%) and opioids (35%); onset of substance use since thirties (81%); substance use started out of curiosity (81%); substance use related lifetime medical complications (35%), and mild impairment in family (66.7%), marital (60.2%), social (49.2%), financial (47.6%) occupational (41.3%) and physical (39.7%) domains. Most of the subjects were detoxi- fied using benzodiazepines (80%) and were not advised pharmacoprophylactic agents (55%). The mean duration of follow-up was 10.82 months and 58.7% were abstaining at the last follow-up. Although the numbers are very small, they show a trend in the recent decades of elderly population's gradually increasing attendance at a de-addiction clinic in India (German J Psychiatry 2008; 11: 10-15).


Drug dependence in adolescents 1978-2003: A clinical-based observation from North India

May 2007

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224 Reads

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47 Citations

The Indian Journal of Pediatrics

To study the demographic and clinical profile of adolescent subjects (< or =18 yr) presenting to a state-funded drug de-addiction centre in north India. Data on demographic and clinical features were extracted from available case notes of adolescent patients who presented to the centre during 1978-2003 (n=85). Many adolescents came from nuclear family (63.5%), of urban background (83.5%) and were school dropouts (54.1%). Mean age-at-first-use of the primary substance was 14.8 yr and mean age at first presentation was 17 yr. The commonest used primary class of substance was opioids (76.2%) and the commonest used opioid was heroin (36.5%). More than half of the subjects (54.2%) were also nicotine dependent at the time of presentation. The most common reason for starting the use of drugs was curiosity (78.8%). About one-fifth (21.2%) of the subjects indulged in high-risk behaviour such as having sexual intercourse with multiple sexual partners. Nearly half of the subjects had positive family history of either drug dependence (40.2%) or psychiatric disorder (5.5%). The results suggest that the development of substance dependence in children and adolescents is a combination of familial and social vulnerability factors, including the drug culture of the social milieu.


Study of stress and vulnerability in patients with somatoform and dissociative disorders in a psychiatric clinic in North India

November 2006

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53 Reads

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14 Citations

Psychiatry and Clinical Neurosciences

The authors compared perceived stress in subgroups of patients defined by vulnerability (high and low) and disorder (somatoform and dissociative). A total of 30 patients each of somatoform and dissociative disorders diagnosed according to the classification of mental and behavioral disorders criteria were assessed with Presumptive Stressful Life Event Scale, The Hassles Scale, Psychoticism Extraversion Neuroticism Inventory, Dissociative Experience Scale, Twenty-Item Toronto Alexithyma Scale, and Illness Behavior Questionnaire. Somatoform and dissociative disorder groups had comparable scores on measures of perceived stress and vulnerability. Two-way anova showed significant main effect of neuroticism (F = 13.65, d.f. = 1.56, P < 0.01), psychoticism (F = 7.92, d.f. = 1.56, P < 0.01), illness behavior (F = 5.82, d.f. = 1.56, P < 0.05), and dissociative experience (F = 8.45, d.f. = 1.56, P < 0.01) on total hassles score, but no significant main effect of disorder groups or interaction effect for disorder and vulnerability was seen on total hassles score. No significant main or interaction effect was seen on life events score. Similarities were seen in stress and vulnerability factors in the two disorders. Neuroticism, psychoticism, dissociative experience, and abnormal illness behavior were significantly related to stress (daily hassles) perceived by the patient, irrespective of the disorder.


Substance-dependent women attending a de-addiction center in North India: Sociodemographic and clinical profile

August 2005

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198 Reads

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41 Citations

Indian Journal of Medical Sciences

Treatment-seeking is limited in women substance abusers. Studying the sociodemographic and clinical profile of treatment-seeking substance-dependent women can help us to understand the problem better and respond appropriately in terms of primary and secondary prevention strategies. To study the sociodemographic and clinical profile of women attending a de-addiction centre in North India. Retrospective structured chart review of 35 women substance abusers. The results indicated that a typical subject was urban (86%), married (63%), nuclear family (60%), based housewife (57%), educated up to school completion (54%), and having poor social support (57%). The common substances were opioids (60%), followed by alcohol (17%), and tobacco and benzodiazepines (11.5% each). The mean age at onset of substance use was 30.5 years, the mean duration of use was 9 years and mean duration to develop dependence was 5.5 years. The common reasons for initiating use were medical (63%) and curiosity (34%). Comorbidity profile was: physical illness (34%), psychiatric illness (23%) and dependence on another substance (14%). Only 20% had a family history of substance dependence. The social impairment ranged from 77% for social to 40% for financial and none for legal aspects. A typical subject had followed up 4.2 times in 8.4 months, while 54% were abstaining, 40% were continuing their substance dependence at the last follow up. The results suggest that the development of substance dependence in women is a combination of genetic, personal, and social vulnerability factors, including the drug culture of the social milieu and the poor social support. Comorbidity and impairment are common features.

Citations (5)


... These were patients who visited the hospital within the past one month for various medical conditions, and sample size was calculated using Cochrane formula 15 . Women are more likely than men to report symptoms of stress 16 , and as such, stress may be under-reported in men. Therefore, this study is focused on understanding the vulnerability of older males to stress. ...

Reference:

Lifestyle, vulnerability to stress and prevailing health conditions of ambulatory older patients in a care facility
Drug Dependence in the Geriatric Age Group: A Clinic Based Study
  • Citing Article
  • January 2008

German Journal of Psychiatry

... Nephrogenic diabetes insipidus is a common adverse effect of lithium [56]. Out of 56 patients who took lithium for an average of 11 years, 39 had urine volumes that exceeded three l/day, of whom 30 spontaneously reported polyuria and 35 reported that the polyuria had caused some dysfunction in their daily routine [57]. The duration of psychiatric disorder, the duration of lithium treatment, and the total number of episodes, particularly depressive episodes, all correlated positively with the polyuria. ...

Distress due to lithium-induced polyuria: Exploratory study

Psychiatry and Clinical Neurosciences

... 9 Two hospital-based studies in India on women with SUD found opioids and tobacco to be the most commonly used substances. 2,3 Thus, the use of tobacco as a primary substance by significantly more women than men in our study agrees with recent evidence. The sex difference in psychiatric comorbidities found in our study is consistent with a recent review. 1 There was significantly lesser number of follow-up visits and a shorter duration of follow-up period among women. ...

Substance-dependent women attending a de-addiction center in North India: Sociodemographic and clinical profile

Indian Journal of Medical Sciences

... ) ، ‫االجياد‬ ‫كمعاناة‬ ‫اليػمية‬ ‫لمزغػط‬ ‫التعخض‬ ‫ك‬ (Irpati et al., 2006 ...

Study of stress and vulnerability in patients with somatoform and dissociative disorders in a psychiatric clinic in North India
  • Citing Article
  • November 2006

Psychiatry and Clinical Neurosciences

... Adolescent participants typically acquired illicit substances from pharmacies, fellow users, and drug dealers, embedded in an intricate network involving selling drugs or stealing money to purchase substances. All these findings are consistent with previous research from India [32][33][34][35][36][37]. ...

Drug dependence in adolescents 1978-2003: A clinical-based observation from North India
  • Citing Article
  • May 2007

The Indian Journal of Pediatrics