Anakele Massi's scientific contributions

Publications (5)

Conference Paper
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Newborn screening lab is in a consistent evolution process if considered the new technologies, new parameters and solutions. We present in this study the evolution of fully automated systems for newborn screening labs using 384 well microplates for quantification of phenylalanine, total galactose, leucine/isoleucine and analysis of enzymatic activi...
Conference Paper
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Introduction: The search for lab innovation in newborn screening is a constant process. The implementation of new markers, the necessity to obtain a robust process, cost effectiveness while minimizing steps, reduce infrastructure adjustments, reduce investments in human resources, keep or improve quality in the results are considered essential poin...
Conference Paper
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Introduction : High numbers of false positives and identification of false negatives suggests adjustment of cut-off values is needed. Many studies about Cystic Fibrosis (CF) and Congenital Adrenal Hyperplasia (CAH) have been published recommending the use of percentiles to correctly classify negative and positives samples, mainly for CF when quanti...
Conference Paper
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Introduction: In the last years the organization called Rede DXB, an MSUD workgroup of specialized professionals in Brazil, has produced actions for development of research and diagnosis of MSUD. MSUD is not mandated by the Brazilian Newborn Screening Program but published data reveals an incidence 5 times higher than expected. The Brazilian indust...
Conference Paper
Full-text available
Introduction : Newborn Screening for Biotinidase Deficiency has been implemented in the Brazilian Newborn Screening Program (PNTN) since 2012. Since 1999 INTERCIENTIFICA offers the NeoLISA BIO kit using an enzymatic colorimetric method that differentiates the enzyme's activity by the color produced in the end of the reaction. The national legislati...