Ana María García-Vicente's research while affiliated with University of Toledo and other places

... Finally, several authors already investigated the potential usefulness of radiomics analysis extracted from baseline [ 18 F]FDG PET/CT prior to the start of NAC to predict both pCR and survival [57][58][59]. Despite very promising results, the main limit to the wide use of radiomics in clinical practice is related to the lack of reproducibility and standardization [60]. ...

... Systemic patient treatment with alpha particle-emitting radiopharmaceuticals is increasingly being applied in standard care for patients with metastatic castrate-resistant prostate cancer [4,5]. Alpha particles considered for treatment have a range of up to 90 µm in water [6] and they have a kinetic energy of about 1.4 to 2.2 MeV per nucleon. ...

... The treatment of bone metastasis arising from breast or prostate cancer currently involves the use of anti-resorptive agents, such as bisphosphonates (i.e., zoledronic acid) [40,41], Denosumab [42] and (in the case of prostate cancer) 223 Radium [43], and these agents have become a central part of treatments used to reduce the impact of SREs within cancer patients. A complete description of the treatment options for bone metastatic cancers is beyond the scope of this review but has been described elsewhere [42,[44][45][46]. ...

... Furthermore, SUV is significatively lower in patients who experience pCR after the second cycle of chemotherapy [52]. Garcia Vicente et al. [65] also analyzed metabolic tumor features with 18 F-FDG PET/CT. In their study including 67 patients, they found that volume-based metabolic variables obtained with 18 F-FDG PET/CT such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), unlike SUV based variables (SUVmax, SUVmean, and SUVpeak), were good predictors of both NAC response and prognosis in locally advanced breast cancer. ...

... [9] Elevated CRP levels have been found to be predictive of positive PET-CT scans in several studies. [13][14][15][16] This is consistent with our study. Bacterial infections are associated with Contd... (1) Metabolically active fascial thickening in the retroperitoneal region [ Figure 1] Skin biopsy -vasculitis; ANCA negative; retroperitoneal fascial biopsy -normal Undifferentiated CTD (1) Mild hepatosplenomegaly ANA positive, nerve biopsy -neurogenic atrophy Granulomatosis with polyangiitis (1) Metabolically active para-aortic, aorto-caval and iliac lymph nodes [ Figure 2] C-ANCA positive; renal biopsy -vasculitis with granuloma Other NIID (9) Adult-onset Still's disease ( Laparoscopic liver and spleen biopsy (this patient had mildly enlared lymph nodes which were not amenable for biopsy) Non-Hodgkin's lymphoma (1) Metabolically active pelvic mass lesion Pelvic mass lesion biopsy Colonic myofibroblastic tumor (1) Metabolically active descending colon mass lesion [ Figure 3] ...

... Traditionally, the evaluation of efficacy has been based purely on morphological data, by means of studying changes in the diameter of lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST) [6]. However, evaluation of the response based exclusively on size change misses important biological and physiological information of the tumor that can be relevant in treatment decision-making [7]. To overcome this limitation, several functional imaging techniques, such as perfusion computed tomography (pCT), have been the subject of extensive research to evaluate the response to therapy in advanced NSCLC patients, particularly to antiangiogenic agents. ...

... locally advanced breast cancer [33]. Together, these data suggest that the use of PET in neoadjuvant therapy can predict long-term outcomes for breast cancer patients. ...

... Conventional features increased over time, as expected (50,51), and Shape features slightly decreased in the delayed PET scan. This decrease in volume due to a higher threshold for lesion delineation (at 40% of SUVmax) agrees with the lower metabolic tumor volume of breast cancer for delayed PET scans (52). The statistically significant Histogram features affected by tracer uptake time were Energy (decreased) and Entropy (increased). ...

... Moreover, beyond SUV max , certain features of intratumoral distribution, and volumetrics of 18 F-FDG, the most common tracer reflecting metabolic activity of the tumor has also been defined. Some of these features have been associated with the receptor status of breast cancer (3,4,5,6,7). However, these PET features do not reflect spatial intratumoral heterogeneity. ...

... Thus, only 46 studies were finally included. Of these, 17 studies focused on the role of 18 F-choline PET/CT in prostate cancer patients with BCR (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). The numbers of included studies regarding 18 F-fluciclovine and 18 F-PSMA PET/CT were 16 and 13, respectively . ...