Ana García-Quintana's research while affiliated with Hospital Clínic de Barcelona and other places

Publications (7)

Article
ABSTRACT Sexual dysfunction in patients with chronic fatigue syndrome (CFS) is attracting growing interest but has been analyzed by few studies to date. For this reason we evaluate sexual dysfunction in women with CFS (GRISS) and explore correlations with fatigue and other symptoms. Sexual dysfunction was greater in CFS patients (n = 615) with a hi...
Article
Full-text available
Background Chronic Fatigue Syndrome (CFS) is a debilitating neuro-immune disorder of unknown etiology diagnosed by an array of clinical manifestations. Although several immunological abnormalities have been described in CFS, their heterogeneity has limited diagnostic applicability. Methods Immunological features of CFS were screened in 22 CFS diag...
Article
Unlabelled: SUMMARY Background: Several lines of evidence support the involvement of inflammatory and immunologic abnormalities in chronic fatigue syndrome (CFS). Since recent studies have shown that α-1 antitrypsin (AAT) possesses anti-inflammatory properties, the potential therapeutic effect of AAT treatment on CFS has been investigated. Cas...
Article
Chronic fatigue syndrome (CFS) is a disabling illness of unknown etiology that is characterized by fatigue associated with a reduced ability to work, lasting for more than 6 months, and accompanied by a specific set of symptoms. The diagnosis remains difficult because of the absence of laboratory tests and is, therefore, made largely on the basis o...
Article
To assess sexual function in women with chronic fatigue syndrome. The study included 27 women, aged 20 to 45 years, with chronic fatigue syndrome (CFS) and 15 healthy female controls. Sexual function was measured with the Golombok Rust Inventory of Sexual Satisfaction (GRISS) questionnaire and five clinical questions. In the patient group, total fa...
Article
Full-text available
Patients affected by chronic fatigue syndrome (CFS) characteristically show easy and unexplained fatigue after minimal exertion that does not resolve with rest and is associated with specific symptoms lasting for more than six months. Cardiopulmonary exercise testing is a valid procedure for determining functional capacity in patients with CFS. We...

Citations

... Despite the crucial importance of SD in women with NMOSD and MS, it is commonly underdiagnosed and undertreated in general clinical practice [36]. It is substantiated that fatigue is present in sexual dysfunction and is associated with neurological symptoms, fibromyalgia, Sjögren's syndrome, or myofascial pain.The prevalence of depression varies in patients with SD [37]. Also, effects of depression on sexual dysfunction and the quality of life can even result in suicide [38]. ...
... (2) reduced oxida tive metabolism [180,247] , mitochondrial dysfunction [248,249] or damage [250,251] ; (3) low cardiac output [101,185] and reduced blood and oxygen supply to the brain [98,129] and muscles [252,253] , possibly leading to acidosis [181,254] , accele rated glycolysis [180] and elevated lactate levels [132,255] ; (4) central sensitisation [256] , as a potential sequel of inflammation [257,258] and oxidative and nitrosative stress [259,260] ; and (5) elevated pain receptors [261,262] . When assessing patients it is crucial to keep in mind that while various symptoms are obligatory for the diagnosis ME [18] , they are not obligatory for to fulfil the CFS [19] diagnostic criteria. ...
... However these variations are perhaps unsurprising as cytokines function in an autocrine and paracrine manner, so their levels in the blood do not necessarily represent levels of inflammation elsewhere (Vanelzakker et al., 2019). There have also been varying perturbations to the T cell populations found in ME/CFS, as well as B cells and natural killer (NK) cells (Ekua Weba Brenu et al., 2014;Cliff et al., 2019;Curriu et al., 2013). The source of these varying changes is unclear. ...
... болическое состояние [38]; 3) редокс-дисбаланс с повышением уровней пероксидов и супероксидов [39], изопростанов [40], снижением концентрации α-токоферола [41], веществ, реагирующих с тиобарбитуровой кислотой [42]; повышенный нитрозативный стресс с увеличением индуцибельной синтазы оксида азота (iNOS), NO, пероксинитрита и нитрата [43]. Накопление внеклеточных ловушек нейтрофилов вызывает при COVID-19 воспаление на клеточном уровне с участием НАДФН-оксидазы, эластазы нейтрофилов, миелопероксидазы, NOS и пептидиларгининдеиминазы 4 с образованием цитруллинированных белков [44]. ...
... Sexual dysfunction is common in patients on chronic hemodialysis and impairment of arousal, orgasm and desire functions are particularly frequent [31]. Fatigue is associated with sexual dysfunction and in particular with difficulty becoming sex aroused also in patients with multiple sclerosis [32,33], in premenopausal women [34], and in chronic fatigue syndrome [35,36]. ...