Ana Almaraz's research while affiliated with Universidad de Valladolid and other places

Publications (71)

Article
Full-text available
ABSTRACT Purposes: We analyzed patient, tumor and dosimetric characteristics of subjects in a Spanish population diagnosed with uveal melanoma treated with iodine 125 (I125) episcleral brachytherapy, who presented with post-treatment loss of useful visual acuity and global evolution of visual acuity. Methods: A single historic observational cohort...
Article
Full-text available
The aim of this work was to ascertain the usefulness of a new commercially-available single-assay chemiluminescence test (CHT) for the diagnosis of human tularemia (Tularaemia VIRCLIA IgG + IgM monotest, Vircell, Santa Fe, Granada, Spain). A total of 773 sera from 773 patients including 364 initial sera from patients with diagnosed tularemia, patie...
Article
Purpose To analize the specific survival of spanish patients diagnosed and treated of uveal melanoma in a national referral unit and compare the results with the previously published in other populationMethods Patients diagnosed of choroidal and ciliary body melanoma between 1992 and 2012 were included. Epidemiologic and general data, clinical and...
Article
Full-text available
To analyse the clinical features, treatment and survival of uveal melanoma patients diagnosed in a referral Intraocular Tumours Unit over a twenty-year period. A prospective study was performed including five hundred patients, diagnosed between January 1992 and December 2011. Clinical tumour characteristics and treatment were collected in a databas...
Article
Full-text available
Objective To analyse the clinical features, treatment and survival of uveal melanoma patients diagnosed in a referral Intraocular Tumours Unit over a twenty-year period. Methodology A prospective study was performed including five hundred patients, diagnosed between January 1992 and December 2011. Clinical tumour characteristics and treatment were...
Article
Fundamento La tularemia era una enfermedad prácticamente inexistente en España hasta finalesde 1997, cuando se declaró un brote epidémico en nuestra comunidad. El objetivo denuestro trabajo ha sido estudiar los datos existentes sobre el diagnóstico microbiológico de 55pacientes que sufrieron tularemia. Pacientes Y Métodos Se obtuvieron 32 muestras...
Article
Full-text available
To assess the results of I-125 episcleral brachytherapy (EB) in uveal melanoma: tumour control, visual acuity (VA), eye preservation and survival. Prospective and consecutive study of patients with a diagnosis of uveal melanoma at the Ocular Oncology Unit in the Valladolid University Teaching Hospital treated with EB between September 1997 and June...
Article
The aim of this work is to investigate the accuracy of the urea breath test (UBT) performed immediately after emergency endoscopy in peptic ulcer bleeding (PUB). Urea breath test was carried out right after emergency endoscopy in patients with PUB. The accuracy of this early UBT was compared to a delayed one after hospital discharge that was consid...
Article
Full-text available
Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber syndrome is a rare autosomal dominant vascular disease characterized by mucocutaneous and gastrointestinal telangiectases and localized arteriovenous malformations in lung, brain and liver. Epistaxis, due to rupture of telangiectases of the nasal mucosa, is the most frequent clinical manif...
Article
Full-text available
The aim of this study was to determine the prevalence of ocular and oculodermal melanocytosis (ODM) among patients with uveal melanoma (UM) in a Spanish population. Retrospective review of the medical records of patients with ODM among patients with UM. Ten (11 eyes) of 400 patients (2.7%) with UM associated had ODM. The mean age at diagnosis of UM...
Article
To report the prevalence of dry eye syndrome (DES) in a subset of patients > 50 years old in Valladolid, Spain, calculate internal validity of two DES screening questionnaires, and correlate the results with DES diagnostic tests. Patients > 50 years-old were randomly selected from the medical network census in Valladolid; they answered the modified...
Article
Purpose: To report the prevalence of dry eye syndrome (DES) in a subset of patients > 50 years old in Valladolid, Spain, calculate internal validity of two DES screening questionnaires, and correlate the results with DES diagnostic tests. Methods: Patients > 50 years-old were randomly selected from the medical network census in Valladolid; they...
Article
Purpose To analyze the time course of diagnosis and treatment of uveal melanomas in an ocular referral unit in a period of 20 years.Methods Prospectively collected data on consecutive patients diagnosed of uveal melanoma, from 1990 to 2010, were analyzed. Epidemiologic and general data, clinical and tumor characteristics at the time of diagnosis (v...
Article
Full-text available
To evaluate episcleral plaque radiotherapy with high-dose (125)I for the treatment of circumscribed choroidal haemangioma (CCH). A retrospective review was performed of patients treated for CCH between 1995 and 2007. Brachytherapy was performed with ROPES plaques loaded with (125)I seeds with a target apex dose of 48 Gy. Main outcome measures were...
Article
Full-text available
To design and validate a standard, simple, and reliable iris color classification and to study its distribution in a Spanish population. Iris color has a geographic distribution and has been correlated with different ocular diseases. However, there is no standard and validated iris color classification allowing comparison among different studies. C...
Article
Full-text available
Objective: although the vaccination against hepatitis A (VAH) and hepatitis B (VBH) is recommended in patients with HCV, the most cost-effective strategy has not been established. Our objective was to compare the cost-effectiveness of universal strategy (vaccination all patients) with selective strategy (vaccination only patients against virus the...
Article
Objective: although the vaccination against hepatitis A (VAH) and hepatitis B (VBH) is recommended in patients with HCV, the most cost-effective strategy has not been established. Our objective was to compare the cost-effectiveness of universal strategy (vaccination all patients) with selective strategy (vaccination only patients against virus they...
Article
Full-text available
to analyze ocular survival in eyes with uveal melanoma treated with conservative therapies, in a centre that applies all treatment modalities. Patients diagnosed with uveal melanoma and treated between September 1990 and April 2007 were included in an historical cohorts study. 273 patients were included. 193 were treated with conservative treatment...
Article
Full-text available
Objective: to analyze ocular survival in eyes with uveal melanoma treated with conservative therapies, in a centre that applies all treatment modalities. Methods: Patients diagnosed with uveal melanoma and treated between September 1990 and April 2007 were included in an historical cohorts study. Results: 273 patients were included. 193 were treate...
Article
Full-text available
We analyzed our experience with the use of capsule endoscopy in areas that can be explored with gastroscopy to justify obscure bleeding, as well as the outcome after a new recommended gastroscopy in order to determine if a second gastroscopy before the capsule study can provide any benefit in the management of this disease. We retrospectively studi...
Article
Full-text available
Our aim was to prospectively compare the behavior of interleukin 18 (IL-18) levels and other immunological parameters during the first week of hospitalization between acute pancreatitis patients with and without severity criteria, as well as between patients with and without late pseudocyst development. In 36 patients with acute pancreatis we compa...
Article
Full-text available
Objective: our aim was to prospectively compare the behavior of interleukin 18 (IL-18) levels and other immunological parameters during the first week of hospitalization between acute pancreatitis patients with and without severity criteria, as well as between patients with and without late pseudocyst development. Patients and methods: in 36 patien...
Article
Because of high fatality rate associated with acute infection by hepatitis A virus (HAV) in chronic hepatitis C patients, it is of interest to know the prevalence of immunization against HAV in these patients. Immunoglobulin G (IgG) IgG HAV antibodies (IgG anti-HAV) were determined in 313 hepatitis C virus antibodies (anti-HCV) positive patients an...
Article
Background and objective Because of high fatality rate associated with acute infection by hepatitis A virus (HAV) in chronic hepatitis C patients, it is of interest to know the prevalence of immunization against HAV in these patients. Patients and method Immunoglobulin G (IgG) IgG HAV antibodies (IgG anti-HAV) were determined in 313 hepatitis C vi...
Article
Purpose To assess the results of I125 Episcleral Brachytherapy (EB) in uveal melanoma: tumor control, visual acuity, eye preservation and survivalMethods Prospective and consecutive study of patients with the diagnosis of uveal melanoma at the ocular oncology unit in the Valladolid University Hospital treated with EB between september 1997 and june...
Article
Both transitory auditory otoemissions (TEOAE) and automated auditory brainstem responses (AABR) are considered adequate methods for universal hearing screening. The goal of this study was to compare the results obtained with each device, applying the same screening procedure. From 2001 to 2003, all the newborns in our health area (2454 infants) wer...
Article
Serological diagnosis of human brucellosis is problematic in endemic brucellosis regions and with patients having a history of brucellosis. The aim of this study is to ascertain the serologic and evolutionary behavior of the tests of serum agglutination, Coombs anti-Brucella, immunocapture-agglutination, enzyme-linked immunosorbent assay (ELISA) Ig...
Article
To confirm the existence of acoustic trauma in classical musicians. Sixty-five volunteers from the Castilla and León Symphony Orchestra were studied. The hearing thresholds of each musician were age-corrected using the ELI and ISO 7029:2000 scales. Furthermore the sound levels of the instruments in this symphony orchestra were studied. We observed...
Article
Objective To confirm the existence of acoustic trauma in classical musicians. Material and method Sixty-five volunteers from the Castilla and León Symphony Orchestra were studied. The hearing thresholds of each musician were age-corrected using the ELI and ISO 7029:2000 scales. Furthermore the sound levels of the instruments in this symphony orche...
Article
Purpose: To analyse eye survival in patients with uveal melanoma with a multimodality approach to treatmentMethods: 273 patients with uveal melanoma diagnosed at Ocular Oncology Unit of the University Hospital of Valladolid from 1997 September to 2007 April. Pearson’s Chi-square test was used to identify between variables and primary enucleation. L...
Article
Introduction Viral hepatitis is a major social, health and economic problem worldwide, requiring strict epidemiological control. Methods This study presents the viral hepatitis seroprevalence in a representative sample from an urban health care area in Valladolid (Spain). Results Antibody prevalence was as follows: anti-HAV 52%; anti-HBc, 8.2%; a...
Article
Viral hepatitis is a major social, health and economic problem worldwide, requiring strict epidemiological control. This study presents the viral hepatitis seroprevalence in a representative sample from an urban health care area in Valladolid (Spain). Antibody prevalence was as follows: anti-HAV 52%; anti-HBc, 8.2%; anti-HCV, 1.1%; anti-HEV, 0.8%;...
Article
To analyze the factors that determine the risk of morbidity and mortality associated with lung resection in patients with bronchogenic carcinoma. Prospective multicenter study conducted between October 1, 1993 and September 30, 1997 in the 19 hospitals that make up the Bronchogenic Carcinoma Cooperative Group. During the study period, 2994 patients...
Article
There is a role of immunologic proinflammatory mediators in pathogenesis of distant organ disfunction in acute pancreatitis (AP). The aim is to evaluate the relationship between those mediators and liver, kidney and lung disfunction in patients with AP. On the day of admission in 34 patients with AP, biochemical parameters of liver function, creati...
Article
Objective TO analyze the factors that determine the risk of morbidity and mortality associated with lung resection in patients with bronchogenic carcinoma. Patients and methods Prospective multicenter study conducted between October 1, 1993 and September 30, 1997 in the 19 hospitals that make up the Bronchogenic Carcinoma Cooperative Group. During...
Article
Background and objective There is a role of immunologic proinflammatory mediators in pathogenesis of distant organ disfunction in acute pancreatitis (AP). The aim is to evaluate the relationship between those mediators and liver, kidney and lung disfunction in patients with AP. Patients and method On the day of admission in 34 patients with AP, bi...
Article
The utility of an immunocapture-agglutination (Brucellacapt, Vircell SL, Granada, Spain) test and an enzyme-linked immunosorbent assay IgG, IgA, and IgM (ELISA-IgG, ELISA-IgA, ELISA-IgM) against cytosolic proteins from Brucella melitensis B115 (R) was compared with ELISA-IgG, ELISA-IgA, and ELISA-IgM against smooth lipopolysaccharide (S-LPS) from B...
Article
To report our experience during a learning period with the Ciaglia Blue Rhino (William Cook Europe) kit for percutaneous tracheotomy. This prospective, observational study included 38 adult patients who underwent elective placement of a percutaneous tracheostomy tube with the Ciaglia Blue Rhino introducer kit. The study was carried out from April 2...
Article
This study was undertaken to compare the ability of five uveal melanocytic cell lines to produce primary and metastatic uveal melanomas in immunosuppressed rabbits and to determine whether animal survival was improved by antibiotic administration. One hundred albino rabbit eyes, five groups of 20, were implanted in the suprachoroidal space with fou...
Article
Full-text available
Leishmaniasis has increased in importance in recent years because infection with human immunodeficiency virus (HIV) has emerged as a risk factor for this disease. However, the actual prevalence of leishmaniasis in the general population of Spain is unknown. We present a study of the seroprevalence of infection with Leishmania infantum in the genera...
Article
Full-text available
Our objective was to investigate the effects of the administration of pancreatic homogenates, with or without enzymatic activation, to healthy animals regarding cytokine serum levels and the development of pulmonary distress. 106 male Wistar rats, divided into three groups, were studied: group A, intraperitoneal administration of homogenates activa...
Article
Human hydatidosis is a prevalent zoonotic disease in the Castilla y León region of Spain. The aim of this study is to investigate the seroprevalence of Echinococcus granulosus infection in this region. We studied 4824 serum samples from a random, representative population of healthy individuals from each province of Castilla y León, obtained over o...
Article
Introduction Human hydatidosis is a prevalent zoonotic disease in the Castilla y León region of Spain. The aim of this study is to investigate the seroprevalence of Echinococcus granulosus infection in this region. Methods We studied 4824 serum samples from a random, representative population of healthy individuals from each province of Castilla y...
Article
The aim of this study was to evaluate the usefulness of a commercial immunoblot (IgG and IgM BAG-Borrelia blot) in the serologic diagnosis of the early stages of Lyme disease. A total of 42 sera from patients with Lyme disease (24 patients with localized early stage (LES) and 18 patients with disseminated early stage (DES)) and 129 sera from patien...
Article
Prior to an outbreak in Castilla y León in December 1997, tularaemia was practically non-existent in Spain. In this paper we studied the prevalence of antibodies against Francisella tularensis in a representative sample of the population (4825 people) from Castilla y León (Spain) in samples collected before this outbreak. Antibodies against F. tula...
Article
The aim of this paper was determine the prevalence of antibodies against Francisella tularensis in the representative sample of people from Castilla-León (Spain) before epidemic outbreak of end 1997. We obtain 4,825 sera (between april-1996 and april-1997) of people from Castilla-León. All sera were tested by a microagglutination technique to detec...
Article
Background and objectives The aim of this paperwas determine the prevalence of antibodiesagainst Francisella tularensis in the representativesample of people from Castilla-León(Spain) before epidemic outbreak of end 1997. Subjects and method We obtain 4,825 sera(between april-1996 and april-1997) of peoplefrom Castilla-León. All sera were tested b...
Article
Objectives This experimental project was designed to evaluate: a) the capacity of oxytetracycline to induce microvesicle steatosis in rat liver when administered over long time periods; b) whether female rats are more susceptible to this substance, and c) the possible ultrastructural alterations and their relation to the mechanisms of steatosis. M...
Article
This experimental project was designed to evaluate: a) the capacity of oxytetracycline to induce microvesicle steatosis in rat liver when administered over long time periods; b) whether female rats are more susceptible to this substance, and c) the possible ultrastructural alterations and their relation to the mechanisms of steatosis. Sixty-two Wis...
Article
To assess the sensitivity, specificity, and reliability of peroxidase labeled lectin staining in the diagnosis of fungal keratitis in an experimental rabbit model. Fungal keratitis by Candida albicans, Aspergillus fumigatus, and Fusarium solani was induced in rabbits. WGA-peroxidase staining of 660 corneal sections was performed. Fungal staining wa...
Article
Full-text available
We evaluated the validity and the usefulness of a new test for the diagnosis of human brucellosis based on an immunocapture-agglutination technique. A total of 315 sera from 82 patients with a diagnosis of brucellosis, 157 sera from patients in whom brucellosis was suspected but not confirmed, and 412 sera from people living in rural areas with end...
Article
Tularemia was practically unknown in Spain until the end of 1997, when an epidemic outbreak was declared. This paper presents the data on microbiological diagnosis of 55 patients who suffered from tularemia. Thirty-two samples from 19 patients and 151 serum samples from 55 patients were obtained for culture. Serologic diagnosis was performed by tub...
Article
BACKGROUND: Tularemia was practically unknown in Spain until the end of 1997, when an epidemic outbreak was declared. This paper presents the data on microbiological diagnosis of 55 patients who suffered from tularemia, PATIENTS AND METHODS: Thirty-two samples from 19 patients and 151 serum samples from 55 patients were obtained for culture. Serolo...
Article
Given the appearance of pancreatitis attributed to tetracycline, as described in the literature, we have investigated its effect on the enzymatic content of pancreas and duodenal fluid and on pancreatic ultrastructure. We have evaluated possible differences between sexes and the relation of our findings with those described in the initial phases of...
Article
Objectives. Given the appearance of pancreatitis attributed to tetracycline, as described in the literature, we have investigated its effect on the enzymatic content of pancreas and duodenal fluid and on pancreatic ultrastructure. We have evaluated possible differences between sexes and the relation of our findings with those described in the initi...
Article
Full-text available
Objectives: Amblyopia is the leading cause of monocular vision loss in people under 40 years, and especially in children. The purpose of the present investigation is to determine the prevalence of amblyopia and ocular pathology, specially the most common causes of amblyopia, in a population of 3-to 6-year-old children. Patients and methods: From...
Article
BACKGROUND AND OBJECTIVES. Prostitutes are a greater risk for hepatitis B virus (HBV) infection than the general population. We studied the influence of age and time as prostitute on HBV infection. We also examined the relationship between syphilis and HBV infection in a cohort of female prostitutes. STUDY DESIGN. The presence of hepatitis B surfac...
Article
In order to determine the frequency of HIV seropositivity of sera from patients attending our hospital emergency department (ED) we used a HIV screening system based on the use of pooled sera. To determine the reliability of this marker we collect all ED serum samples during two different intervals of a week. From 577 sera analyzed by this method w...
Article
We have studied the prevalence of hepatitis B (HBV) and hepatitis C virus (HCV) serologic markers in female blood donors and in female prostitutes and the relationship of antibodies to hepatitis B core antigen (anti-HBc) and of antibodies to HCV (anti-HCV) with the presence of treponemal antibodies (FTA-ABS) in non-intravenous drug using female pro...
Article
The prevalence of antibodies against Hepatitis C Virus (anti-HCV antibodies) and its association with the presence of treponemal antibodies (FTA-ABS) was studied in 227 non-drug abusing female prostitutes. The overall anti-HCV antibody prevalence was 8.8%, and a significantly higher prevalence of anti-HCV antibodies was found in prostitutes testing...
Article
RESUMEN Objetivo: hemos analizado los hallazgos que la cápsula endos-cópica aportó de las zonas accesibles a una gastroscopia que po-drían justificar un sangrado digestivo oscuro, así como la evolu-ción de estos enfermos tras la nueva gastroscopia recomendada para determinar si una segunda gastroscopia previa a la cápsula podría añadir beneficios e...

Citations

... A review of this technique was published by Dr. Morais using submucosal injections of polidocanol. He performed nearly 300 injections in 45 patients for 15 years [8]. Nosebleeds improved both in frequency and quantity in 95% of the cases, and no relevant side effects were reported. ...
... The intermediate eye colored individuals with almost same ratio (similar to present work) have been reported worldwide; 12.5% in Poland, 11.65% in Kazakhstan (Ulivi et al., 2013;Katsara and Michael, 2019), 14.15% in Iceland (Sulem et al., 2007), 6.02% in Uzbekistan (Katsara and Michael, 2019) and 7.67% in Tajikistan (Ulivi et al., 2013;Katsara and Michael, 2019). In contrast to the present finding, intermediate eye colored individuals are present much higher percentage in France (44%), Spain (55.2%) and Germany (39.6%) (Diaz et al., 2009;Katsara and Michael, 2019). Blue eye color is the most prevalent eye color in Iceland (73.90%), ...
... Finalmente, el reporte histopatológico permite clasificar al tumor como mediano con varios datos de mal pronóstico (localización en cuerpo ciliar, tamaño mediano y estirpe de células epitelioides), con mortalidad del 31.8% a los 10 años, requiriendo el seguimiento estricto de la paciente que a la fecha lleva 4 años sin datos en la PET-CT de hiperactividad metabólica que sugieran metástasis. 11,12 Como conclusión, el oftalmólogo deberá tener presente al melanoma dentro de sus diagnósticos diferenciales ante cualquier tumoración del cuerpo ciliar, siendo el ultrasonido ocular su herramienta auxiliar más importante, pudiendo brindar un tratamiento oportuno bajo el apoyo del oncólogo. ...
... 9,10 The most used treatment modality for uveal melanoma patients at our ocular oncology unit is iodine-125 brachytherapy. 11 In a previous study with a 3-year average follow-up period we reported a low rate of treatment failure. 12 The purpose of this report is to document the incidence of local tumor recurrence after iodine-125 brachytherapy for uveal melanoma at a Spanish intraocular tumor referral unit. ...
... 13 It is also lower than the estimates reported by Gower et al. 3 and data reported from previous studies conducted in Spain before 2017. [14][15][16][17][18][19][20][21][22][23][24][25] As expected, prevalence was lower than in the first seroprevalence study in Spain performed in 1996 (1.4%). 22 By contrast, our estimates were closer to those of population-based studies from more recent periods. ...
... Mitochondria are affected by the presence of tetracycline, probably due to its complexation with metals, or due to its interaction with biomolecules. Tetracyclines are known for their deleterious metabolic effects, that include deficient mitochondrial β-oxidation of fatty acids, inhibition of mitochondrial respiration, and damage to mitochondrial DNA, resulting in an accumulation of triglycerides and lipid inclusions inside the cytoplasm − steatosis (Pastor et al., 2002;Jaeschke et al., 2002;Machado et al., 2003). The β-oxidation of fatty acids appears to be a critical process, because the resulting acetylcoenzyme A moieties are the primary source of ATP in most cells (Sturgill and Lambert, 1997). ...
... In our series of patients with chronic HCV infection we found a rate of immunization against HAV of 81.2%, similar to that found by other authors (16). Because antiHAV prevalence is lower among younger individuals, 50% of our patients with chronic HCV infection under 41 years were susceptible to acute infection with HAV, as described in an epidemiological study done by our group in this same population (17). ...
... In order to detect ocular discomfort and dryness symptoms, many different questionnaires have been developed, including the ocular surface disease index (OSDI) [1], the five-item dry eye questionnaire (DEQ-5) [2], the dry eye-related quality of life score (DEQS) [3], the impact of dry eye on everyday life (IDEEL) [4], the McMonnies' questionnaire (MQ) [5], the ocular comfort index (OCI and OCI-I) [6], the symptom assessment in dry eye (SANDE) [7] or the standard patient evaluation of eye dryness (SPEED) [8]. On many occasions, there is no clear correlation between the clinical signs (tear volume and tear stability measurements, cornea %l staining, etc.) and the results of the questionnaires [9][10][11][12][13]. Although many different explanations have been proposed for this issue, one of the simplest is that the questionnaires may detect early symptoms in subjects without clear clinical signs [13], especially in young subjects. ...
... Most of the hazardous sound exposure among these musicians occurs during rehearsals, individual practice, and other music activities [2,4,5,7]. Frequent exposure to high sound levels is associated with hearing loss [9][10][11][12] and with other hearing-loss-related symptoms, such as tinnitus, hyperacusis, and diplacusis [10][11][12][13][14]. Recent evidence suggests that about 40% of musicians report hearing difficulties [15]. Musicians have an approximately fourfold higher hazard ratio (HR) for NIHL and 57% 2 of 12 higher HR for tinnitus when compared to the general population [12]. ...