Amr Ali's research works | McMaster University, Hamilton (McMaster) and other places

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Fig. 1. Representative baseline PSMA-PET, metastasis-directed RT (MDRT)...

Fig. 2. SMA expression in human prostate tumor specimens. PSMA...

Fig. 4. PSMA expression in untreated and irradiated prostate cancer...

Fig. 5. PSMA expression in radiation-resistant clones of prostate...

18F-DCFPyL (PSMA) PET as a radiotherapy response assessment tool in metastatic prostate cancer

Article

Full-text available

Mar 2023

Background: Prostate Specific Membrane Antigen (PSMA) - positron emission tomography (PET) guides metastasis-directed radiotherapy (MDRT) in prostate cancer (PrCa). However, its value as a treatment response assessment tool after MDRT remains unclear. Importantly, there is limited understanding of the potential of radiotherapy (RT) to alter PSMA g...

Fig. 1. Response of PrCa cells to Metformin (MET) and radiotherapy...

Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses

Article

Full-text available

Nov 2021

Background There is need for well-tolerated therapies for prostate cancer (PrCa) secondary prevention and to improve response to radiotherapy (RT). The anti-diabetic agent metformin (MET) and the aspirin metabolite salicylate (SAL) are shown to activate AMP-activated protein kinase (AMPK), suppress de novo lipogenesis (DNL), the mammalian target of...