Amit Sharma's research while affiliated with International Centre for Genetic Engineering and Biotechnology and other places

... Trimethylamine N-oxide (TMAO) originates from the enzymatic oxidation of the gut microbiota metabolite trimethylamine (TMA). It is also absorbed directly from food [1]. Serum TMAO levels depend on the dietary intake of TMA precursors [2], the quantitative and qualitative composition of the gut microbiota [3], and kidney function [4,5]. ...

... It has been stated that periodontitis could be a contributing factor for atherosclerosis [10], not only by the increase of the systemic inflammatory burden but also by transitory bacteremia present in patients that suffer from this disease [11]. Several studies have identified periodontal pathogens in atherosclerotic plaques but the effect of those microorganisms in the initiation and progression of atherosclerosis is not completely understood [12,13]. ...

... The increased concentration of TMAO in the body has been associated with health problems such as inflammatory processes, risk of arteriosclerosis, neurological disorders, or kidney damage, among other diseases. However, the mechanism associated with these damages is still unknown (Barrea et al., 2018;Brial et al., 2018;Chhibber-Goel et al., 2017;Coras et al., 2019;Dove et al., 2012;Farmer et al., 2021;Gatarek & Kaluzna-Czaplinska, 2021;Janeiro et al., 2018;Koeth et al., 2013). One of the characteristics of COVID-19 is the appearance of inflammatory processes, which could be leading to increased levels of TMAO in the urine of COVID-19 patients, as occurs with other inflammatory processes (Tang et al., 2015;Yang et al., 2019). ...

... Drug repurposing methodologies and structure-based conservation techniques that target invariant parasite house-keeping proteins may lead to novel foci for drug development [19]. The structure of the Pfk13 protein has previously been analyzed for the distribution of ART-R mutations and its dimerization interfaces, utilizing the publicly available threedimensional structure [20,21]. To date, two crystal structures of Pfk13 proteins are available in RCSB Protein Data Bank (4YY8 and 4ZGC). ...

... The TMA molecules are produced directly or indirectly mainly from food compounds containing L-carnitine and choline, but also from betaine and lecithin, ergothioneine and gamma-butyrobetaine. TMAO production is not a clear consequence but can potentially be influenced by dysbiosis and individual polymorphisms in the expression of FMO3 in the liver [14]; as well as the intake of fish and other seafood in the diet, [26] and a more systemic disease [29,30]. As well as genetic factors and environmental factors, recent evidence suggests that even the metabolites deriving from the microbiota can play a protective role or promote the onset of tumors. ...