Amit Dang's research while affiliated with University of Kentucky and other places

Publications (58)

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Background: Many Ayurvedic preparations are claimed to have immune-boosting properties, as suggested in various published randomized clinical trials (RCTs). Aim: To compile evidence on the nature and mechanism of immune system enhancement by Ayurvedic preparations in healthy and sick individuals. Methods: After prospectively registering study...
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The ever-increasing use of digital technologies is rapidly changing the face of modern healthcare delivery. Healthcare systems are embracing digital health solutions to improve patient outcomes, enhance healthcare delivery, and reduce costs. Digital therapeutics (DTx) are now a popular category of digital health solutions aimed at preventing, manag...
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One of the few positive outcomes of the ongoing COVID-19 pandemic is that it has enhanced the pace of digitalisation of healthcare. Among various facets of digital health, Digital Therapeutics (DTx) is unique as it offers evidence-based interventions for preventing, managing, or treating specific disorders. It is different from wellness apps becaus...
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Objective To review the importance of evidence-based methods in health insurance reimbursement for achieving universal health coverage in India. Methods A narrative literature review was performed. Results The out-of-pocket (OOP) healthcare expenditure in India is among the highest in the world. This situation is despite the implementation of num...
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Introduction and Objective Ivermectin (IVM) and doxycycline (DOXY) have demonstrated in-vitro activity against SARS-CoV-2, and have a reasonable safety profile. The objective of this systematic review was to explore the evidence in the literature on the safety and efficacy of their use as monotherapy and combination therapy in COVID-19 management.M...
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Background We critically evaluated the risk of bias in published systematic reviews (SRs) and meta-analyses (MAs) pertaining to COVID-19 using ROBIS tool. Materials And Methods Medline and Cochrane Central Library were searched for SRs/MAs on 14th May 2020, including studies of all designs describing various facets of COVID-19 in humans; no restri...
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Background: We compared the response rates, survival rates, and safety profile of epidermal growth factor receptor (EGFR) inhibitors with non-targeted chemotherapy and older EGFR inhibitors when used to treat advanced nonsmall cell lung cancer (NSCLC) patients with activating EGFR mutations. Methods: We searched PubMed, Cochrane Central Register o...
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Background We performed a critical overview of published systematic reviews (SRs) of chemotherapy for advanced and locally advanced pancreatic cancer, and evaluated their quality using AMSTAR2 and ROBIS tools. Materials and Methods PubMed and Cochrane Central Library were searched for SRs on 13th June 2020. SRs with metaanalysis which included onl...
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The world is going through an unprecedented medical emergency with no effective remedy for the SARS-CoV2 virus causing Covid-19. Two drugs used for other indications in the past, hydroxychloroquine (HCQ) and remdesivir (RDV), are sought to be repurposed to treat Covid-19. Both these drugs have received emergency use authorisation by the US Food and...
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With healthcare becoming digital, patients today are more empowered than ever before. As a result, digital health solutions have become the need of the hour to keep up with an increasing number of empowered patients participating in their own treatment decisions. Digital health encompasses various platforms and systems that apply technological solu...
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Background: Real-world safety of bevacizumab in cancer patients is limited. Objective: To review the adverse drug reactions (ADRs) due to bevacizumab in cancer patients, in published case reports. Methods: PubMed was searched; case reports of patients having any cancer, administered with bevacizumab (monotherapy/ combination) and reporting ADR...
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Background Prostate cancer (PCa), the sixth primary cause of cancer death. Still, conflicts are present about the efficacy and safety of Non-steroidal anti-androgens (NSAA). Aim of this study was to assess the efficacy and safety of NSAAs versus any comparator for the treatment of advanced or metastatic PCa. Methodology MEDLINE and the Cochrane Li...
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Background: Most countries recommend that their healthcare personnel be vaccinated against influenza in order to protect themselves as well as their patients. However despite the strong scientific rationale, recommendations and advocacy from health organizations, influenza vaccination coverage among healthcare personnel remains low. This has been...
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Most of the industrial sectors of India have undergone major changes in the post-liberalization period. During this period, India has become self-reliant in drugs; however, still, 75% of the medical devices are imported in India. According to WHO, almost all devices present in the developing countries have been designed for use in the industrialize...
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BACKGROUND: Prostate cancer (PCa) is the sixth leading cause of cancer death and the second most common cancer in men across the world. An estimated 1.1 million men worldwide were diagnosed with prostate cancer in 2012. By 2030, PCa burden is expected to be 1.7 million new cases and 499,000 new deaths. OBJECTIVE: To evaluate the efficacy and safet...
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In an attempt to reduce costs of clinical trials and increase recruitments, pharmaceutical companies have been shifting their trials to offshore locations in Asia, Africa, the Middle East, Eastern Europe, and Latin America. Hence, methods for conducting clinical trials need to be adapted to the varying languages, cultures, ethnicities, and socioeco...
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objectives: To evaluate the association between saxagliptin and cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Methods: Literature searches were performed in PubMed, CENTRAL, and ClinicalTrials.gov. In addition, reference lists of included studies were cross-checked for relevant studies. RCTs (≥24 weeks) that compared saxagl...
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Randomized controlled trials (RCTs) are the gold standard for measuring the safety and efficacy of drugs. However, they are being challenged by payers and health care providers since they are looking for real world evidence (RWE) to validate whether the new intervention provides similar safety and efficacy as reported in RCT data. RWE uses real wor...
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Health economic studies provide information to decision makers for efficient use of available resources for maximizing health benefits. Economic evaluation is one part of health economics, and it is a tool for comparing costs and consequences of different interventions. Health technology assessment is a technique for economic evaluation that is wel...
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The private health-care system in India is effective but expensive. Due to the absence of a comprehensive and well-penetrated insurance scheme that caters to the majority of the Indian population, most of the private health care consultations are out-of-pocket (OOP), and this is pushing many people to poverty. In this article, we describe the conce...
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Background: World Health Organization (WHO) recommends the use of Xpert MTB/RIF assay for rapid diagnosis of tuberculosis (TB) and detection of rifampicin resistance. This systematic review was done to know about the diagnostic accuracy and cost-effectiveness of the Xpert MTB/RIF assay. Methods: A systematic literature search was conducted in fo...
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One of the important components of patient-centered healthcare is comparative effectiveness research (CER), which aims at generating evidence from the real-life setting. The primary purpose of CER is to provide comparative information to the healthcare providers, patients, and policy makers about the standard of care available. This involves resear...
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Objective: To evaluate the efficacy and safety of canagliflozin in combination therapy among patients with type 2 diabetes mellitus with inadequate glycemic control. Methods: Two review authors independently searched for the relevant randomized controlled clinical trials from the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, I...
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Introduction: Cancer is reported to cause about 0.4 million deaths annually. The cost of diagnosis and treatment of cancer in India is enormous. Aim: This Health Technology Assessment (HTA) aims to understand the role, effect on mortality and adverse event occurrence, and cost effectiveness of phytomedicine in cancer treatment. Materials and Method...
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PCN162 Mammography For Breast Cancer Screening In India – A Health Technology Assessment Kachroo K1, Sharma J2, Chahar A3, Dang A4, Ganji K4 1National Health System Resource Centre,Ministry of Health and Family Welfare,Government of India, New Delhi, India, 2National Health Systems Resource Center, Ministry of Health & Family Welfare, New Delhi, In...
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With the Indian patient becoming more empowered with regards to his disease and its treatment options, many Indian physicians still depend only on disease-related outcome measures to take health-care related decisions, and give minimal importance to patient-centered outcomes pertaining to the effect of the healthcare interventions on the patient's...

Citations

... COVID-19 pandemic has significantly boosted the digital transition in healthcare and many digital health solutions became key components in keeping non-COVID-19 pathways running. Consumer-grade digital tools for routine monitoring and diagnosis in multiple diseases are increasingly used by physicians (Dang et al., 2021). According to the IQVIA Report on Digital Health Trends, published in July 2021, investments on digital health has increased, reaching a record $24 billion of investments 2020, mainly driven by continued acceleration of mergers and acquisitions and a growing impact of private equity investors (The IQVIA Institute., 2021). ...
... 5 A safety analysis of ivermectin and doxycycline monotherapy as well as in combination in the treatment of COVID-19 was recently published. 9 Two hundred articles were screened, which included 19 studies (6 retrospective cohort studies, 7 randomized controlled trials [RCTs], 5 nonrandomized trials, 1 case series, and preprinted) with 8754 unique patients in various stages of COVID-19. Safety profile was addressed in only 6 studies. ...
... Perhaps the main deterrent for routine NAT in Indian blood banks is economic in origin. The additional cost incurred by routine testing of each donation using NAT invariably passes on to the patient's pockets, especially since health insurance coverage is quite low in India [13]. ...
... Although chemotherapy is successful for patients with non-small cell lung cancer, patients who are treated with chemotherapy suffer from many negative symptoms due to the destruction of the immune system by it [6]. In the search for a therapy for non-small cell lung cancer, some studies have indicated the efficacy of treating patients with non-small cell lung cancer with inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase domain (TKD) [7][8][9]. Erlotinib is used as a drug that inhibits the active sites of the EGFR protein, thereby inhibiting the NSCLC pathway [10][11][12][13] . The H460 cell line is one of the major NSCLC cell lines targeted *Address correspondence to this author at the Laboratory of Engineering, Systems and Applications, National School of Applied Sciences, Sidi Mohamed Ben Abdellah-Fez University, BP Box 72, Fez, Morocco; E-mail: ossama.daoui@usmba.ac.ma by Erlotinib through the EGFR protein [14]. ...
... The methodological quality of the included studies was assessed using the Cochrane RoB-2 tool [15]. We used the official Microsoft Excel tool provided by the Cochrane Foundation for implementing RoB-2, and we used separate tools for parallel group RCTs and crossover RCTs [16]. ...
... There is, therefore, the need to have effective treatments for people infected with SARS-CoV-2. Current treatments of SARS-CoV-2 include two prominent drugs that were used for other indications, hydroxychloroquine (HCQ) and Remdesivir (RDV) [65]. HCQ has had mixed results in Covid19 treatment, however, when coupled with azithromycin it resulted in a good clinical outcome and a virological cure in 973 out of 1061 patients within 10 days (91.7%) [66]. ...
... Knowledge of digital medicine among many medical workers and patients is limited to remote consultation and online drug purchase. Currently, the definition of digital medicine is controversial, but definitions commonly include clinical evidence-based technologies and products that will ultimately have a direct impact on the diagnosis, prevention, monitoring, and treatment of diseases, symptoms, and syndromes [2,[4][5][6]. Digital medicine is occasionally referred to as "mobile health" [7]. ...
... However, previous studies indicated that side effects usually increased when bevacizumab was combined with chemotherapies [357,358]. These opposite results indicate that the clinical responses and toxic side effects may depend on the specific therapeutic schemes and conditions [359]. As for its therapeutic outcomes in combination with chemotherapies, some published meta-analyses assessed the additional effect of chemotherapy plus bevacizumab, and the results indicated that, compared to chemotherapy alone, the combinational strategy improved the PFS and OS in cancer patients [360][361][362][363]. Nonetheless, disappointing outcomes are still existed. ...
... Making vaccine available free of cost or at subsidised rates for healthcare workers, increasing availability at multiple sites and incentive strategies are a few steps to be considered for implementation to augment vaccination to a satisfactory level. [22] An interesting incentive scheme implemented in Greece during 2016-2017 influenza season was to give 1 day off work for vaccinated HCPs. [23] Such novel schemes and studies in similar lines, when put into effect, can potentially improve the vaccination uptake in HCPs. ...
... 59 PIM co-targeting could also reduce patient mortality by potentiating the antimetastatic effects of other treatments, including strategies targeting the PI3K pathway 60,61 or JAK/STAT pathway 62,63 or anti-androgen therapy. 64 PIM AND THE PI3K PATHWAY The PI3K/AKT/mTOR pathway has been shown to contribute to the development of all hallmarks of cancer and is frequently disrupted in cancer. 65 Three generations of drugs targeting this pathway have been under widespread clinical development for multiple cancers. ...