January 2020
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5 Reads
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1 Citation
Journal of Applied Pharmacy
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January 2020
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5 Reads
·
1 Citation
Journal of Applied Pharmacy
... [5] Metronidazole indication FDA-approved MTZ for the treatment of a broad range of infections such as intestinal amebiases, liver amebiasis, bacterial septicemia, bone and joint infections, central nervous system (CNS) infections (meningitis and brain abscess), endocarditis, gynecologic infections (endometritis, tuboovarian abscess, bacterial vaginosis), intra-abdominal infections, lower respiratory tract infections, skin structure infections, and surgical prophylaxis surgeries. [7] Mechanism of action Metronidazole diffuses into the organism, inhibits protein synthesis by interacting with DNA and causing a loss of helical DNA structure and strand breakage. Therefore, it causes cell death in susceptible organisms. ...
January 2020
Journal of Applied Pharmacy