Álvaro Andreu-Bernabeu's research while affiliated with Hospital General Universitario Gregorio Marañón and other places

Publications (21)

Article
Resumen Este trabajo de revisión analiza el estado de los conocimientos sobre la Telepsiquiatría (TP) tras la crisis provocada por el COVID y la consiguiente necesidad de utilizar nuevas modalidades de atención. Se abordan seis aspectos inherentes a la TP: la satisfacción de los pacientes y del personal de salud mental, la fiabilidad diagnóstica, l...
Article
Introduction Social functioning is severely affected in psychotic disorders. Negative symptoms and social cognition seem to play an important role in social functioning, although the preponderance and relationship between these three domains is not clear. In this study, we sought to assess the interrelation between social cognition, social function...
Article
Background and Hypothesis A pro-inflammatory phenotype has been related to psychotic disorders. The neutrophil-lymphocyte ratio (NLR) is an accessible biomarker that could be helpful to characterize this systemic inflammation state. Study Design This study evaluated the NLR in a cohort of 310 subjects with a first episode of psychosis (FEP) and a...
Article
Full-text available
Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10−8) was crossed for varia...
Article
Introduction: The COVID-19 pandemic has renewed the interest in telepsychiatry as a way to help psychiatrists care for their patients, but mental health providers' unfamiliarity and concerns may impede implementation of such services. This study aimed to determine the effect of an online educational intervention on awareness, knowledge, attitude, a...
Article
Neurotrophins have been proposed to be involved in biological mechanisms which might underlie different clinical outcomes in schizophrenia. The aims of the present study were to examine the BDNF/NGF plasma levels in a cohort of first-episode schizophrenia (FES) patients in remission as potential biological predictors of relapse; to study the associ...
Article
Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed. Methods: . The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/re...
Article
Full-text available
Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic varia...
Article
Background . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed. Methods . The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regi...
Article
Full-text available
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating t...
Article
Full-text available
Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than...
Article
Introduction Advanced parental age (APA) has been associated with an increased risk for autism in the offspring. One explanatory model includes delayed fatherhood in parents with autistic traits. Material and methods We investigated (1) whether autistic traits in parents, evaluated with the Autism-spectrum Quotient (AQ), correlate with APA in 128...
Article
Background: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable children and adolescents is crucial. Methods: The Collaborative Outcomes study on Health and Functioning during Infection Times (C...
Article
Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID�19 pandemic are needed. Methods: . The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/r...
Article
Full-text available
Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episod...
Preprint
BACKGROUND The COVID-19 pandemic has renewed the interest in telepsychiatry as a way to help psychiatrists care for their patients, but mental health providers’ unfamiliarity and concerns may impede implementation of such services. This study aimed to determine the effect of an online educational intervention on awareness, knowledge, attitude and s...
Preprint
Full-text available
There is increasing recognition of the association between loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate significant LNL-ISO polygenic score prediction on schizophrenia in an independent case-control sample (N=3,488). We then dissect schizophrenia predisposing variation into subsets of variants based on their ef...

Citations

... Certainly, in the context of the Rome IV criteria, there would be fewer cases of functional disorders, because the more recent criteria are stricter. In summary, their results should indicate that the COVID-19 pandemic negatively affected patients with functional disorders, mainly due to stress [24]. ...
... With the accelerated spread of the Omicron variant, a specific "city-wide lockdown" was imposed in Shenzhen lasting for 10 days. This home confinement negatively influenced resident's physical and mental health Hosen et al., 2021;Hossain et al., 2020;Solmi, 2022) as it was a driver of a series of unhealthy behaviors including the decrease of regular pyhsical activity (PA) and the increase of sedentary behaviour (Chen et al., 2020a(Chen et al., , 2020bGuerrero et al., 2020;Lin et al., 2020;Racine et al., 2021;Stockwell et al., 2021). The latter was exacerbated by the fact that Shenzhen as a highly developed area in China with high prices of commodities and housing conditions resulting in crowded living. ...
... Adolescents aged 14 to 17 can participate in COH-FIT-AD. Co-primary outcomes of COH-FIT-AD are well-being, measured with WHO-5 23 as in COH-FIT-C, and a composite psychopathology measure, "AD-P-Score" that is composed of the same items composing the coprimary P-Score outcome in adults (COH-FIT-A) (Solmi et al., 2021). Briefly, domains composing the P-score in COH-FIT-A were selected based on their correlation with the respective full validated questionnaires (Pearson correlation threshold r ≥ 0.5), among anxiety, depression, post-traumatic symptoms, psychosis, mania, obsessive-compulsive symptoms, stress, sleep, and concentration. ...
... Schizophrenia-polygenic-score and cannabis use, independently from each other, are related to more severe positive symptomatology. 2,6,12 The goal of the current study, which is part of the Athens-FEP Study, is to present the Greek translation of TAQEUGEI and CEQEUGEI and to examine the test-retest reliability of the Greek translations of the two questionnaires. ...
... There is a consensus that early intervention can lead to a higher rate of symptomatic remission and better functional outcomes in patients with schizophrenia, potentially by preventing and/or ameliorating active brain changes at the early stages of the illness (4,5). However, current evidence supports that clinical and neurobiological factors associated with early neurodevelopmental pathology e.g., premorbid intelligence (6), obstetric complications (7), and gross brain morphology (8,9) as well as genetic factors (10) may also contribute to worse functional outcomes and symptom severity in later stages of schizophrenia. In recent years, as described below, event-related potential (ERP) abnormalities are considered to be suitable biomarkers of functional recovery for schizophrenia (11) and clinical high risk (CHR) patients (12,13). ...