Alma Contegiacomo's research while affiliated with University of Naples Federico II and other places

... Thirteen publications were excluded due to lack of thyroid hormone measurements, whereas 16 publications on tamoxifen evaluated thyroid hormones were eligible for inclusion in the systematic review. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] A detailed flow diagram is shown in Figure 1. ...

... An increased intracellular concentration of polyamines is necessary for the activation of DNA synthesis and cell replication [1][2][3][4]. The intestinal replicating cells are particularly capable of accumulating polyamines promoting both their synthesis, through the activation of the enzyme ornithine decarboxylase, and their uptake from the extracellular space [5][6][7][8][9]. Caco-2 cells, derived from a human colon carcinoma, after confluence spontaneously differentiate assuming morphological and functional features similar to those of the small intestinal enterocytes. ...

... Literature data showed that presence of pre-existing psychological distress and concerns are the best know psychological prognostic factors [14]. This is one of the reasons why most individuals apply for genetic counseling on their own, having high selfperceived risk of genetic predisposition [15][16][17][18]. In a review article by Gopie et al. (2012), it appeared that young age, perception of high risk, pre-existing psychological distress, a passive way of coping, little social support and family members with cancer were predictive of psychological problems and/or reduced quality of life. ...

... Approximately, 15-20% of all BCs diagnosed lies in the category of TNBC tumors (13). Compared with other types of tumors, TNBC tumors have an aggressive appearance, a poor prognosis, and high recurrence rates (14)(15)(16)(17)(18)(19)(20)(21). These breast cancer subtypes have pool of genes involved in different pathways associated to each other of the aforementioned receptors due to activation or suppression of different genes. ...

... IR leads to cellular and molecular damages via direct or indirect actions. Therefore, chromosomal aberrations, cell death, alterations in the oxidation status of cells and alterations in cellular haemostasis in tumours as well as normal tissues are expected after irradiation (3). Prominent effects of sparsely IR such as X-rays or gamma rays include the formation of free radicals that interact with nucleic acids and lead to DNA damage. ...

... Six of 88 breast cancers (7%) showed MSI, and then four of six had ER-and PgR negative features. However, it is difficult to determine the features of MSI breast cancer, because MSI is remarkably rare in breast cancer [33,34]. A study reported that in 267 breast cancers, no tumors had MSI using PCR at 104 primers, including markers considered to be highly reliable for detection of MSI in colorectal cancers and reported previously to have in breast cancers [7]. ...

... Вариабельность показателя чувствительности МРТ колебалась от 75,2 до 100 %, в среднем превышая 80 %; специфичность -от 83 до 98,4 % (исследование EVA и итальянское исследование HIBCRIT-1) [39,40]. Использование короткого протокола МРТ Kuhl et al, ассоциируется с сокращением времени сканирования в среднем на 18,8 мин и интерпретации изображений -на 4,9 мин. ...

... The significance of such deletions in the 13th and 23rd introns are unknown, despite being found in 11 and 3 samples, respectively. Previous research has suggested that variants in the splicing site of intron 13 altered the maturation of mRNA and may play a role in breast and ovarian cancer [28], but no definite associations in PC can be made. However, intronic variants newly discovered from GWAS studies rather than conventional exome-based analyses have been linked to cellular signaling and differentiation that ultimately result in PC progression [29], and as such, these novel mutations may play a role in metastatic conversion. ...

... In these studies, the single administration of CPT-11 or ETOP produced good results, with response rates of 16 -47% and an MST of 3.5 -6.2 months (Einhorn et al, 1990;Johnson et al, 1990;Masuda et al, 1992;Le Chevalier et al, 1997). Moreover, CPT-11 or ETOP-containing combined chemotherapy regimens showed favourable results, with response rates of 20 -88% and an MST of 4.7 -8.7 months (Table 4) (Evans et al, 1985;Masuda et al, 1990;Sculier et al, 1990;Gridelli et al, 1991;Roth et al, 1992;Faylona et al, 1995;Kubota et al, 1997;Masuda et al, 1998;Groen et al, 1999;Nakanishi et al, 1999;von Pawel et al, 1999;Domine et al, 2001;Kosmas et al, 2001). Therefore, these two drugs are considered to be key drugs for the treatment of relapsed SCLC. ...

... Nejlépe prozkoumaným a charakterizovaným stimu- látorem uvolňování DAO je heparin, který je uvolňo- ván z granulí aktivovaných žírných buněk a bazofilů společně s histaminem (22,40). Snížená schopnost uvolňovat a generovat DAO po stimulaci intravenóz- ně aplikovaným heparinem je dobře dokumentována u pacientů s poškozenou střevní sliznicí, ale byla po- zorována také u jiných onemocnění a korespondu- je s aktivitou a koncentrací DAO nalézanou v séru (8,9,10,14,38). Nezodpovězenou otázkou však zůstá- vá, nakolik koresponduje předpokládaná zvýšená ak- tivita enterocytů střevní sliznice, způsobená stimulací histaminem podaným přímo do střeva, spojená s pro- dukcí DAO s aktivitou a koncentrací DAO nalézanou po této stimulaci v séru. ...