Aliya Muratovna Sarsenbayeva’s scientific contributions

In this literature review, methods for the detection of breast cancer biomarkers and the operation of electrochemical sensors are considered. The work of sensors in the determination of breast cancer biomarkers was systematized, a comparative table with other methods was compiled, as was a classification of sensors depending on their intended use. The various traditional methods for the diagnosis of breast cancer biomarkers are described, including mammography, ultrasound, magnetic resonance imaging, positron emission computed tomography, computed tomography, single-photon emission computed tomography, and biopsy, and their advantages and disadvantages are presented. Key sensor parameters for the detection of breast cancer biomarkers are compared, such as the detection limit, linear detection range, response time, sensitivity, and other characteristics depending on the analyte being analyzed. Based on the reviewed scientific papers, the significance of electrochemical sensors in detecting the biomarkers of breast cancer is demonstrated. The types of tumor biomarkers identified by biosensors were analyzed, with a particular focus on HER2. Studies on HER2 detection using electrochemical methods are compared and systematized, and the features of electrochemical biosensors for determining this biomarker are characterized. Possible interfering agents affecting the accuracy of HER2 determination under experimental conditions are considered, their mechanisms of action are analyzed, and ways to eliminate them are proposed. This report provides a summary of the current aspects of scientific research on electrochemical sensors for the detection of breast cancer biomarkers. The development of electrochemical biosensors opens up new prospects for the early diagnosis and prognosis of breast cancer treatment.

Molybdenum and its compounds are widely used in production and industry due to their properties, such as mechanical strength, heat resistance, high electrical conductivity, high melting point and electrochemical catalytic activity. Therefore, their processing is undoubtedly a very urgent problem. One of the ways to solve this problem is associated with the use of aqueous-organic electrolyte solutions. The purpose of the work: to determine the patterns of electrochemical dissolution of molybdenum in aqueous solutions of dimethyl sulfoxide. Research methods. The work uses electrochemical (polarization measurements, electrolysis), X-ray spectral, microphotographs, and mathematical analysis methods. Results and discussion. Electrochemical dissolution of molybdenum in 0.25 M, 0.5 M, and 2 M LiCl solutions in an aqueous solution of dimethyl sulfoxide at different potential transfer rates is considered. The presence of water in electrolytes enhances the process of molybdenum transition into solution, the appropriate concentration of 0.25 M LiCl water was 38 mol/L H2O. At these electrolyte concentrations, the thickness of the film formed on the molybdenum surface was estimated, the distance between adjacent defects, and the electrical conductivity of the film were determined. Concept. Electrochemical properties of the molybdenum electrode in an aqueous solution of dimethyl sulfoxide do not obey the laws of classical electrochemistry. Separation of molybdenum from the solid phase under such electrolytic conditions will undoubtedly have great application, for example, in the processing of solid foundry waste and the production of biosensors.