Alexandre Cusson's research while affiliated with CHU Sainte-Justine and other places

Publications (6)

Article
Background Unmeasured confounding can bias the relationship between exposure and outcome. Sensitivity analyses generate bias-adjusted measures but these are not much used; this may change with the availability of the E-value (for evidence for causality in observational studies), appealing for its ease of calculation. However, as currently proposed,...
Article
Selection bias remains a more difficult bias to understand than confounding or measurement error. Past definitions have not always been illuminating and a simple method (such as the change-in-estimate method for confounding) has not been available to determine its presence and magnitude in the study sample. A better understanding of the nature of t...
Article
Full-text available
Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure...
Article
Radiosynoviorthesis (RS) is an intra-articular injection of a radioactive colloid for the treatment of synovitis administered most often to patients with rheumatoid arthritis or haemophilia. Although highly cost-effective in comparison with surgical or arthroscopic synovectomy, the risk of cancer associated with this treatment is not well known. We...

Citations

... Furthermore, the studies included were mostly focused on NCDs captured in health facility-settings. So selection bias may have contributed to the overestimation of the prevalence of NCDs due to over selection, or underestimation due to ascertainment of more severe presentations of these conditions (13). Community based studies have been shown to represent a more accurate population prevalence of disease (14). ...
... Previous studies have shown brominated and chlorinated flame retardants to be associated with adverse health effects, including reproductive toxicity, neurologic impairment, hormonal disturbances, and cancer [13][14][15]. The Epilymph study, a multicenter case-control study, demonstrated a significantly increased risk of mature B-cell lymphomas in patients exposed to brominated flame retardants [16]. ...
... The probability of a serious adverse event (e.g., intraarticular infection or radiogenic tissue necrosis) is below 0.1 per 1000 [6]. The radiogenic induction of a malignant tumor after RSO has never been described, even after long-term follow-up [7]. Thus, radiosynoviorthesis is one local treatment option in the large armamentarium of different therapies for patients suffering from chronic synovitis. ...