Alan Lehmann’s research while affiliated with University of Sussex and other places

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Publications (2)

Enhancement of XPG mRNA expression by human interferon-β in Cockayne syndrome cells
  • Article

August 1998

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5 Reads

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9 Citations

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Katsuo Sugita

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Nobuo Suzuki

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Alan Lehmann

Using PCR-differential display, we have searched for genes expressed specially in human interferon (HuIFn)-beta-treated Cockayne syndrome (CS) fibroblast cells. Eighteen expressed genes induced by HuIFN-beta were identified, the sequences of seven of which were highly homologous to previously cloned sequences. The cDNAs of six of these seven clones were similar to expression tagged sequences from unknown genes in databases and the remaining one was identical to the cDNA of the xeroderma pigmentosum XPG gene. These results, together with our previous finding of increased resistance to ultraviolet (UV) cell-killing of CS cells pretreated with HuIFN-beta prior to UV irradiation suggest that XPG might be one of the genes possibly involved in the HuIFN-beta-induced UV-resistance.

Citations (2)

... Notably, both RSa and KT cells also show high sensitivity to cell proliferation inhibition by human interferon-β (HuIFN-β) (3). Coordination between cellular sensitivity to UVC and HuIFN was observed in various human cell lines, but the mechanisms underlying the coordination remain unclear (4)(5)(6). However, cellular chaperone metabolism may be the key for clarifying these mechanisms. ...

Reference:

Involvement of heat shock protein 27 in the susceptibility of KT human breast cancer cells to UVC and interferon lethality
Enhancement of XPG mRNA expression by human interferon- in Cockayne syndrome cells
  • Citing Article

  • July 1998

Mutation Research/DNA Repair

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R. d'Arge

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Alan Lehmann

... However, cellular chaperone metabolism may be the key for clarifying these mechanisms. Notably, UVC-sensitive cells, pretreated with HuIFN-β and then irradiated with UVC, become resistant to UVC lethality (5,6); however, the role of the chaperones in the HuIFN-β effect has not been studied. ...

Reference:

Involvement of heat shock protein 27 in the susceptibility of KT human breast cancer cells to UVC and interferon lethality
Enhancement of XPG mRNA expression by human interferon-β in Cockayne syndrome cells
  • Citing Article

  • August 1998

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Katsuo Sugita

·

Nobuo Suzuki

·

·

[...]

·

Alan Lehmann