Aidan C. Manning's research while affiliated with University of California, Santa Cruz and other places
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Publications (4)
Following transcription, tRNAs undergo a series of processing and modification events to become functional adaptors in protein synthesis. Eukaryotes have also evolved intracellular transport systems whereby nucleus-encoded tRNAs may travel out and into the nucleus. In trypanosomes, nearly all tRNAs are also imported from the cytoplasm into the mito...
Extracellular tRNA‐Derived Small RNAs In article number 2200829, Saumya Das and co‐workers provide a comprehensive landscape for the signature of cellular and extracellular tRNA‐derived small RNAs (tDRs) in response to different stressors. They also determine a distinct fragmentation pattern for extracellular tDRs distinct from cellular tDRs and in...
The cellular response to stress is an important determinant of disease pathogenesis. Uncovering the molecular fingerprints of distinct stress responses may identify novel biomarkers and key signaling pathways for different diseases. Emerging evidence shows that transfer RNA‐derived small RNAs (tDRs) play pivotal roles in stress responses. However,...
The cellular response to stress is an important determinant of disease pathogenesis. Uncovering the molecular fingerprints of distinct stress responses may yield novel biomarkers for different diseases, and potentially identify key signaling pathways important for disease progression. tRNAs and tRNA-derived small RNAs (tDRs) comprise one of the mos...
Citations
... (Cristodero et al., 2021). Similarly, in vitro experiments suggested human ANG efficiently cleaves CCA ends before anticodon cleavage, likely inducing global translation inhibition (Czech et al., 2013). However, recent studies based on next generation sequencing revealed most of the 3 0 -tiRNAs had intact CCA termini (Akiyama, Lyons, et al., 2022;G. Li et al., 2022;Su et al., 2019), implying that ANG predominantly targets anticodon loops compared to CCA termini. Therefore, at least in human cells, the impact of CCA-shortening on translation seems small. ...
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