Adi Rattner's research while affiliated with Johns Hopkins University and other places

Publications (4)

Article
Associations between sleep disordered breathing (SDB) and cardiometabolic outcomes have not been examined in highlanders. We performed nocturnal polygraphy in Peruvian highlanders (3825 m). Multivariable linear regression models examined associations between SDB metrics and haemoglobin, glucose tolerance (haemoglobin A1c (HbA1c)), fasting glucose,...
Article
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Background: Altitude can accentuate sleep disordered breathing (SDB), which has been linked to cardiovascular and metabolic diseases. SDB in highlanders has not been characterized in large controlled studies. The purpose of this study was to compare SDB prevalence and severity in highlanders and lowlanders. Methods: 170 age-, body-mass-index- (B...
Article
Full-text available
Study objectives: Sleep disordered breathing (SDB) is a highly prevalent condition in high-income countries, with major consequences for cardiopulmonary health, public safety, healthcare utilization, and mortality. However, its prevalence and effect in low- and middle-income countries are less well known. We sought to determine the prevalence, ris...
Article
Full-text available
Background: Sleep-disordered breathing (SDB) is a highly prevalent disorder with major consequences for cardiopulmonary health, public safety, use of health-care, and mortality. Hypoxia is a known risk factor for SDB, yet the prevalence and effect of SDB in high-altitude settings remain largely unknown. Methods: The CRONICAS Cohort Study is a longi...

Citations

... In such an environment, periodic breathing is highly prevalent, 5 and the presence of more severe hypoxemia is associated with worsening cardiovascular and metabolic risk. 6,7 Rodent models of sustained hypoxia (SH) and intermittent hypoxia (IH) are useful to demonstrate particular cardio-metabolic effects and to understand mechanisms downstream of hypoxic exposure which might account for these effects. SH causes pulmonary hypertension in rodents, 8,9 but does not elevate systemic blood pressure. ...
... Also, ventilatory sensitivities to O 2 and CO 2 play a key role in sleepdisordered breathing in highlanders (70,75), and low ventilatory sensitivity to hypoxia or CO 2 can lead to more severe desaturation during sleep and/ or prolonged desaturation periods (76). Recent studies have shown that sleep-disordered breathing is more prevalent in Peruvian highlanders than in lowlanders at sea level (71), and nocturnal hypoxemia and sleep apnea events are independently associated with EE. We have recently shown that lower pulse O 2 saturation (SpO 2 ) during sleep and during the day are associated with higher hematocrit in Andean men and women. ...
... Sleep-disordered breathing (SDB) is common among individuals living at high altitude (highlanders), with sleep apnea symptoms reported in up to 30%, 1 and increased prevalence and severity of sleep apnea, 2 potentially exacerbating and/or accelerating the progression of the long-term sequelae of SDB. Highlanders with sleep apnea have a unique pattern of hypoxemia, with more marked intermittent hypoxemia from sleep apnea against a background of sustained hypoxemia from altitude. ...