Adele J. Kapellusch's research while affiliated with McKnight Brain Institute and other places

Publications (2)

Article
Background Our understanding of the neural systems that subserve navigation and spatial processing can be greatly improved through access to experimental approaches that allow for precise spatial and temporal control of the sensory information that inform these systems. Furthermore, paradigms that incorporate concurrent behavioral metrics of naviga...
Article
Full-text available
Young and aged animals were tested on a spatial alternation task that consisted of two interleaved components: (1) an “outbound” or alternation component (working memory) and (2) an “inbound” component, requiring the animal to remember to return to a central location in space (spatial memory). In the present study, aged rats made more outbound erro...

Citations

... VR has been applied to great effect in recent years as a powerful experimental tool [4,5,6,7,8,9,10,11] to investigate neural and behavioral correlates of the 'cognitive map' in rodents [12]. According to O'Keefe and Nadel, elements of the cognitive map form the foundation of memory formation and retrieval [13,14,15], and spatial navigation [16]. ...
... When dealing with many aging captive nonhuman primate populations, we must consider the effects of their cognitive abilities, motivation, and participation in experiments that vary across the 262 RAWLINGS, LEGARE, BROSNAN, AND VALE life span because these will ultimately have consequences on the conclusions we draw. Whether animals attempt and persist at tasks, for example, can decline with age (Barbary macaques, Macaca sylvanus; Rathke & Fischer, 2020), whereas perseveration with known solutions or strategies can increase (rhesus macaques; Lai et al., 1995; e.g., on aging and cognitive decline in other species, see Chapagain et al. [2020] for dogs, Kapellusch et al. [2018] for rats, and Kwapis et al. [2020] for mice). Openness, linked with cognitive performance, also changes over the chimpanzee life span-with males in particular decreasing over adulthood (Rawlings et al., 2020). ...