Ac’s research while affiliated with University of Plymouth and other places

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Publications (171)


The epistemological irony of postcolonialism: A perspective from Paul’s flesh-Spirit dichotomy
  • Article
  • Full-text available

November 2023

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104 Reads

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1 Citation

Verbum et Ecclesia

La G Philip

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La G Du Philip

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Among other things, postcolonialism claims to react against western epistemology. Although postcolonial approaches react to the traditional tendency in colonialism to silence the Other by political, social and economic structures and ideologies, non-western identity is often categorised in a way in which identity formation is argued to be based on a naturalistic process of social construction and myth-making. The way in which identity is perceived in western epistemology, including the in-Christ identity, is largely influenced by a naturalistic stance, which is a prominent tendency in western epistemology. In contrast, non-western epistemologies often perceive spiritual beings and powers to be real, which are considered to intervene in human affairs. The irony within most postcolonial approaches is thus that they critique western power structures but continue to utilise western, naturalistic epistemologies to deconstruct religious experience. In this contribution, this discrepancy is explored and evaluated against the often-misunderstood flesh-Spirit dichotomy in the Pauline corpus.

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کاربرد سه روش تخمین برای پیشبینی میزان پیشروی دستگاه حفر تونل TBM

With the proliferation of underground excavations for tunnels, tunnel boring machines, known as TBM extent in industry. The machine according to different geological structure, atmosphere, etc., can affect the boring progression different. In modern mathematical studies on them three methods linear regression, neural networks and genetic algorithms to predict drilling speed and the results do indicate that the neural network with 67% accuracy is best. Genetic algorithms with 58% and regression 46% accuracy can be used for predict.


Figure 1: Proportion of victims and perpetrators with a mental health diagnosis
Key risk and contextual factors
Beyond intimate partner relationships: utilising domestic homicide reviews to prevent adult family domestic homicide

October 2021

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302 Reads

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18 Citations

Journal of Gender-Based Violence

Increasing evidence documents domestic violence and abuse (DVA) and domestic homicide of adults killed by a relative in non-intimate partner relationships. Most literature focuses on intimate partner violence and homicide, yet non-intimate partner homicides form a substantial but neglected minority of domestic homicides. This article addresses this gap by presenting an analysis from 66 domestic homicide reviews (DHRs) in England and Wales where the victim and perpetrator were related, such as parent and adult child. Intimate partner homicides are excluded. These 66 DHRs were a sub-sample drawn from a larger study examining 317 DHRs in England and Wales.The article contributes towards greater understanding of the prevalence, context and characteristics of adult family homicide (AFH). Analysis revealed five interlinked precursors to AFH: mental health and substance/alcohol misuse, criminal history, childhood trauma, economic factors and care dynamics. Findings indicate that, given their contact with both victims and perpetrators, criminal justice agencies, adult social care and health agencies, particularly mental health services, are ideally placed to identify important risk and contextual factors. Understanding of DVA needs to extend to include adult family violence. Risk assessments need to be cognisant of the complex dynamics of AFH and must consider social-structural and relational-contextual factors. Key messages Understanding of domestic violence and abuse needs to include adult family violence. Risks and dynamics of adult family homicide are complex and must consider social-structural and relational-contextual factors. Criminal justice agencies, social care, substance misuse and mental health services provide opportunities for prevention. </ol


Growth Performance of Ross Broilers fed Dietary inclusion of Hydrolyzed Chicken Feather Meal

September 2021

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99 Reads

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2 Citations

Annals of the Romanian Society for Cell Biology

This research was designed to evaluate the growth performance of Ross broilers given diet that included hydrolyzed feather meal. Two hundred and twenty-five day-old Ross 308 broiler strains of chicken was used for the study period of eight weeks, the chicks were randomly distributed to five experimental diets namely D1 (control), D2 (Inclusion of HCL precipitated hydrolysed feather meal), D3 (Inclusion of HNO 3 precipitated hydrolysed feather meal), D4 (Inclusion of H 2 SO 4 precipitated hydrolysed feather meal) and D5 (Inclusion of H 3 PO 4 precipitated hydrolysed feather meal). Each experimental diet consisted of 45 broilers replicated thrice with 15 birds per replicate in a complete randomized design. The data obtained was caused to undergo statistical analysis. The result of proximate composition of the test ingredients of different acid-treated feather meal showed that hydrolysed feathers precipitated with HNO 3 had highest level of protein content (83.63%) compared with other acid-treated feather meal, followed by feather meal treated with HCL (82.40%), while hydrolysed feathers precipitated with H 2 SO 4 and HNO 3 had similar level of protein content. Notable differences (P<0.05) were observed across the diets for feed intake, daily weight gain, feed conversion ratio and final weight. Conclusively, the HCL hydrolysed feather meal diet performed similar to the control diet.


An Implementation of a Blockchain-based Data Marketplace using Geth

July 2021

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423 Reads

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6 Citations

Nowadays data is one of the most important assets that can be obtained, as many applications rely on data to generate useful services. However, a very few number of companies control, in a centralized manner, a large portion of data. That, combined with inefficiencies in centralized storage and recent data leak scandals, highlights the need for new ways in which data is shared and consumed, in which privacy and access control is guaranteed by design. Based on that, in this paper we present an implementation of a blockchain-based data marketplace utilizing the Go Ethereum (Geth) library. The implementation consists of an IoT node powered by a raspberry pi zero W, which is utilized to collect data from the environment and store it in an InterPlanetary File System (IPFS) external server, a web page that displays the marketplace, and a private blockchain that records transactions. Regarding the private blockchain, three smart contracts are developed in order to: 1) record information about the data in the marketplace; 2) record transactions that occur between users; 3) allow sellers to white/blacklist buyers' access to the data. This implementation shows that a decentralized blockchain-based marketplace is feasible and scalable, and we hope it can serve as an early model for future frameworks.


Fig. 2. Workflow of the virtual screening.
Fig. 3. Top selected mutant of Main Protease.
Fig. 4. The binding of top scoring compounds (A) Binding of Imiglitazar within the active site of Mpro (WT) (B) Binding of PF-03715455 within the active site of Mpro (Y54C) (C) Binding of Salvianolic acid A within the active site of Mpro (N142S) (D) Mpro (T190I) (E) Binding of Montelukast within the active site of Mpro (A191V).
Fig. 5. Molecular dynamics results of the Imiglitazir-WT Mpro complex (Black), PF-03715455-Y54C (red), Salvianolic acidA-N142S (green), Salvianolic acidA-T190I (blue) and Montelukast-A191V (Yellow). (A) The ligand RMSD selected compounds (B) The backbone RMSD of Mpro (WT) and mutants in complex the selected compounds (C) The intermolecular hydrogen bond formations (D) The RMSF plot of the WT and mutant Mpro.
Screening of drug databank against WT and mutant main protease of SARS-CoV-2: Towards finding potential compound for repurposing against COVID-19

February 2021

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134 Reads

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27 Citations

Saudi Journal of Biological Sciences

Although several pharmacological agents are under investigation to be repurposed as therapeutic against COVID-19, not much success has been achieved yet. So, the search for an effective and active option for the treatment of COVID-19 is still a big challenge. The Spike protein (S), RNA-dependent RNA polymerase (RdRp), and Main protease (Mpro) are considered to be the primary therapeutic drug target for COVID-19. In this study we have screened the drugbank compound library against the Main Protease. But our search was not limited to just Mpro. Like other viruses, SARS-CoV-2, have also acquired unique mutations. These mutations within the active site of these target proteins may be an important factor hindering effective drug candidate development. In the present study we identified important active site mutations within the SARS-CoV-2 Mpro (Y54C, N142S, T190I and A191V). Further the drugbank database was computationally screened against Mpro and the selected mutants. Finally, we came up with the common molecules effective against the wild type (WT) and all the selected Mpro. The study found Imiglitazar, was found to be the most active compound against the wild type of Mpro. While PF-03715455 (Y54C), Salvianolic acid A (N142S and T190I), and Montelukast (A191V) were found to be most active against the other selected mutants. It was also found that some other compounds such as Acteoside, 4-Amino-N- {4-[2-(2,6-Dimethyl-Phenoxy)-Acetylamino]-3-Hydroxy-1-Isobutyl-5-Phenyl-Pentyl}-Benzamide, PF-00610355, 4-Amino-N-4-[2-(2,6-Dimethyl-Phenoxy)-Acetylamino]-3-Hydroxy-1-Isobutyl-5-Phenyl-Pentyl}-Benzamide and Atorvastatin were showing high efficacy against the WT as well as other selected mutants. We believe that these molecules will provide a better and effective option for the treatment of COVID-19 clinical manifestations.


Last Round Convergence and No-Dynamic Regret in Asymmetric Repeated Games Le Cong Dinh Tri-Dung Nguyen

January 2021

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44 Reads

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2 Citations

This paper considers repeated games in which one player has a different objective than others. In particular, we investigate repeated two-player zero-sum games where the column player not only aims to minimize her regret but also stabilize the actions. Suppose that while repeatedly playing this game, the row player chooses her strategy at each round by using a no-regret algorithm to minimize her regret. We develop a no-dynamic regret algorithm for the column player to exhibit last round convergence to a minimax equilibrium. We show that our algorithm is efficient against a large set of popular no-regret algorithms the row player can use, including the multiplicative weights update algorithm, general follow-the-regularized-leader and any no-regret algorithms satisfy a property so called "stability".




Citations (67)


... It is known that 8% of homicide victims in England between Oct 2019 and Sept 2020 were carers (Home Office, 2023). Interactions between long-term caring, "vulnerabilities" of the cared for person and serious harm and abuse are beginning to be recognised in both domestic homicide reviews (Benbow et al., 2019;Bracewell et al., 2022) and mental health homicide reviews (Condry and Miles, 2023). Although not explicitly categorised or quantified, it seems likely that carer harm is a feature of crimes or police enquiries relating to assault, domestic incidents and rape. ...

Reference:

Carer harm: a challenge for practitioners, services and research
Beyond intimate partner relationships: utilising domestic homicide reviews to prevent adult family domestic homicide

Journal of Gender-Based Violence

... A feather meal is a good source of escaping protein as well. Due to the high keratin content and strong disulphide bonding of the amino acids, raw feathers are very intractable and have a low digestion of only 5% (Alabi 2021, Chand, 2017. Alpha (α) and beta (β) keratins are two different types of keratins. ...

Growth Performance of Ross Broilers fed Dietary inclusion of Hydrolyzed Chicken Feather Meal

Annals of the Romanian Society for Cell Biology

... However, when explicit communication is not feasible, achieving those necessary cooperative behaviours becomes a significantly more difficult situation. Recently, there has been a line of research investigating whether such cooperative behaviours can emerge by just observing and reacting to the played strategies of the opponents [10,11,6]. A key challenge here is not just to identify the appropriate opponents to cooperate, but to know when to switch sides as well. ...

Last Round Convergence and No-Dynamic Regret in Asymmetric Repeated Games Le Cong Dinh Tri-Dung Nguyen

... Convergent algorithms and dynamics, often referred to as last-iterate convergence, are extensively studied within the community of learning in games. The focus is mainly on computationally efficient algorithms with faster rates of convergence or global convergence guarantees (Daskalakis and Panageas 2019;Golowich, Pattathil, and Daskalakis 2020;Mertikopoulos et al. 2019;Wei et al. 2021;Lei et al. 2021;Nguyen et al. 2021;Anagnostides et al. 2022;Abe, Sakamoto, and Iwasaki 2022). In the majority of these studies, convergence is ensured through modifications to the learning algorithm. ...

Last Round Convergence and No-Dynamic Regret in Asymmetric Repeated Games Le Cong Dinh Tri-Dung Nguyen

... Paulo Valente Klaine et al. suggested [24] a blockchain-based data marketplace that trades data stored into the InterPlanetary File System (IPFS). They suggested a private blockchain, which is smart contract-compatible, and the smart contracts are used to record data information in the marketplace. ...

An Implementation of a Blockchain-based Data Marketplace using Geth

... While docking plays a secondary but important role in optimizing hits to leads, the variability of the SARS-CoV-2 genome can hinder the prevention and treatment of the disease. The CADD approach can effectively predict the impact of mutations on drug binding to molecular receptors, aiding in the discovery of new medications or the repurposing of FDA-approved drugs with established safety and side effect profiles [99]. Therefore, CADD is the most crucial technology in modern drug development and has undoubtedly accelerated the development of drugs for treating COVID-19. ...

Screening of drug databank against WT and mutant main protease of SARS-CoV-2: Towards finding potential compound for repurposing against COVID-19

Saudi Journal of Biological Sciences

... By adversely affecting the progress of science and aggravating the underdevelopment of societies, scientific misconduct and violations can lead to the degradation of the international status of countries. In this context, the most important consequence of scientific misconduct is the retraction of published scientific works (Kamali et al., 2020;Marco-Cuenca et al., 2021;Masters, 2012). This process, which is typically considered the self-correction of the scientific community, is a necessary step to maintain the integrity of the entire scientific ecosystem (Ajiferuke & Adekannbi, 2020;Chen et al., 2013). ...

Plagiarism, Fake Peer-Review, and Duplication: Predominant Reasons Underlying Retractions of Iran-Affiliated Scientific Papers in publishing · Fake peer-review · Iran · Manuscript · Retraction of publication

Science and Engineering Ethics

... In 2002, a local study has proposed the three modular architecture: "basic, clinical notes and prescribing" for the "Electronic patient record for Sri Lanka ambulatory care" (35) . COPE has described in the prescribing module and electronic prescribing was identified as the main of that proposed system. ...

Electronic Patient Records -the Reality

... To construct the BN prediction model, also called the BN classifier, the authors considered tree augmented naïve Bayes (TAN) and general BN (GBN) classifiers, which are known to outperform naïve Bayes (NB) in terms of classification accuracy [23]. Yousefi et al. employed Dynamic BN in both their studies [42], [43] that models BN in a probabilistic manner, making it suitable for modeling complex and dynamic processes. ...

Opening the Black Box: Discovering and Explaining Hidden Variables in Type 2 Diabetic Patient Modelling

... Although it lacks a-type variant antigens, the T. congolense genome does contain two a-type VSG subfamilies (Fam14 and Fam15) that are not used in antigenic variation but are instead homologous to T. brucei PAG and TfR genes [6,9] ( Figure 1C). Like T. brucei, T. congolense VSG genes are also spread throughout the subtelomeres, small chromosomes, and telomere-proximal sites [32]. ...

The structure of a conserved telomeric region associated with variant antigen loci in the blood parasite Trypanosoma congolense

Genome Biology and Evolution