Abolfazl Sarikhani's research while affiliated with Tehran University of Medical Sciences and other places

Publications (6)

Article
Full-text available
The combination of multiple therapeutic and diagnostic functions is fast becoming a key feature in the area of clinical oncology. The advent of nanotechnology promises multifunctional nanoplatforms with the potential to deliver multiple therapeutics while providing diagnostic information simultaneously. In this study, novel iron oxide-gold core–she...
Article
Recent years have seen considerable progress in the development of nanomedicine by the advent of 2D nanomaterials serving as ideal platforms to integrate multiple theranostic functions. We synthesized multifunctional stimuli-responsive 2D-based smart nanocomposites (NCs), comprising gold nanoparticles (AuNPs) and superparamagnetic iron oxides (SPIO...
Article
Full-text available
Nanotechnology-based photothermal therapy (NPTT) is a new emerging modality of cancer therapy. To have the right prediction and early detection of response to NPTT, it is necessary to get rapid feedback from a tumor treated by NPTT procedure and stay informed of what happens in the tumor site. We performed this study to find if proton magnetic reso...
Article
Molecular imaging (MI) of cancer is an emerging field in diagnostic imaging that provides means for visualization, characterization, and quantification of cancer biology in vivo. Various targeted nanoprobes (NPs) have been introduced to enhance signal and/or contrast, binding avidity, and targeting specificity for early detection of cancer. The ove...
Article
The integration of multiple therapeutic and diagnostic functions into a single nanoplatform for image-guided cancer therapy has been an emerging trend in nanomedicine. We show here that multifunctional theranostic nanostructures consisting of superparamagnetic iron oxide (SPIO) and gold nanoparticles (AuNPs) scaffolded within graphene oxide nanofla...
Article
Background Photo-thermal therapy (PTT) has been at the center of attention as a new method for cancer treatment in recent years. It is important to predict the response to treatment in the PTT procedure. Using magnetic resonance spectroscopy (MRS) can be considered a novel technique in evaluating changes in metabolites resulted from PTT.Methods In...

Citations

... Here, NIR activation simultaneously combines thermo-chemotherapy with accelerated drug release. In order to visualize the biodistribution of the graphene-based nanocomposites (NCs) in vivo, gold nanoparticles (AuNPs) and superparamagnetic iron oxide (SPIO) NPs were anchored on GO nanosheet surface to enable computed tomography (CT) [40][41][42][43] and magnetic resonance imaging (MRI) [44][45][46]. The surface of the NCs was also modified with an alginate (Alg) polymer hydrogel to improve their biocompatibility and colloidal stability under physiological conditions [47]. ...
... (Hirsch et al. 2003) Among various nanoparticles, gold nanoparticles (AuNPs) have evolved greatly in the fabrication and application of nanomaterials for tumor therapy, owing to their excellent photo-stability and physicochemical properties, high atomic number, low toxicity, and efficient light-to-heat conversion capacity. (Beik et al. 2019(Beik et al. , 2021) Therefore, AuNPs can provide a unique opportunity to cooperate with different treatments at the same time, thus highlighting the value of AuNPs in the synergistic treatment of tumors. Conventional AuNPs are usually prepared by dangerous and complicated chemical methods, and the preparation process is mainly accompanied by high temperature, high pressure, and unnecessary toxicity. ...
... The active targeting of the liposomes can be achieved via the attachment of various conjugating moieties, including small molecules ligands, monoclonal antibodies, and peptides to the surface of the liposomes. Certain receptors, i.e., transferrin and folate receptors, are overexpressed in various kinds of cancers [38,39]. To achieve targeted delivery, the specific ligands of these receptors are attached to the surface of the liposomes, which in turn increase the affinity and binding capacity of the liposomes to the cancer cells, and thus results in targeted delivery [40,41]. ...
... Nanomedicine [13][14][15][16], particularly use both fundamental science and bio-molecular engineering, in order to have better precision medicines [17]. Even though there have been various treatment regimens using nanomedicines, phototherapy is of great importance as it is minimally invasive and causes no side effects on the body [18][19][20][21][22]. There are two main streams of phototherapy, namely photo-thermal therapy (PTT) and photo-dynamic therapy (PDT), and both of them use light as their main source of action. ...