Abhijeet Singh Mehta's research while affiliated with University of Dayton and other places

Publication (1)

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Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggressive and juvenile onset of ALS. FUS is a well-conserved protein across different species, which pla...


... Cell death could be rescued by downregulating the Hippo pathway. 326 In SOD1(G93A) mice, which are a commonly used mouse ALS model, genetic deletion of MST1 could improve spinal cord motor neuron viability and decrease mortality. 327 Finally, in HD mice, deficiency in TEAD/YAP-dependent transcription could lead to necrotic cell death. ...