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A pragmatic measure of quality program can be equated with graduate employability. In Malaysia, the issue of graduate unemployment has attracted national attention. Employers state that lack of generic skills and inability to transfer learning from classroom to the workplace is the main factor for graduate unemployment. Thus, in designing education that prepare students to fulfill job market requirements, a radical shift of curriculum design, pedagogical methods and assessment practices need to be reconsidered. A model that integrates Problem-based Learning (PBL) strategies is a worthy candidate since students are trained to be real practitioners from the beginning of their training. Although the shift would require significant reform in practices, it will stimulate students to develop and possess the knowledge and skills demanded in the working world. This paper outlines the design and the practice of a Biomedical Science subject that implement hybrid PBL. The instructor's and learners' experience in teaching and learning the module is discussed. As part of practice focus, we report the potentials, the hurdles and the students' perceptions about the value lies in learning the subject. Finally, solutions established to overcome the various challenges are described.