May 2025
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Advanced treatment options of cerebral aneurysms (CAs), in particular percutaneous treatment, are gaining fast attention by researchers and practitioners. The eCLIPs implant (product of Evasc Neurovascular Enterprises, Vancouver, Canada) has recently revolutionized the percutaneous treatment of CAs by offering innovative solutions to the challenges pertinent to other neurovascular devices, i.e. excessive vessel injury caused by device and artery interaction and blocking the daughter vessels in bifurcation cases. However, in a subset of CAs at the bifurcation location with fusiform pathology, eCLIPs fails to provide sufficient neck bridging, where a gap exists between the device structure and the aneurysm/artery wall upon device deployment. We have proposed an innovative solution for this problem by developing a new design for the eCLIPs (VR-e) by making the length of device ribs variable to cover such an inflow gap. We have developed a new computational framework to optimize the new product development process and evaluate the device behavior during crimping into a catheter and expansion at the aneurysm neck, which is not possible by testing a new device for the endovascular application experimentally. In spite of the longer rib span in the VR-e over eCLIPs, the device structure has not experienced plastic deformation during the crimping process. The VR-e device fully expanded and covered the inflow gap when deployed at the neck.