Aaron L. Sarvet's research while affiliated with École Polytechnique Fédérale de Lausanne and other places

Publications (46)

Preprint
Avoiding harm is an uncontroversial aim of personalized medicine and other epidemiologic initiatives. However, the precise mathematical translation of "harm" is disputable. Here we use a formal causal language to study common, but distinct, definitions of "harm". We clarify that commitment to a definition of harm has important practical and philoso...
Preprint
Full-text available
Researchers are often interested in estimating the effect of sustained use of a pharmacological treatment on a health outcome. However, adherence to strict treatment protocols can be challenging for patients in practice and, when non-adherence is expected, estimates of the effect of sustained use may not be useful for decision making. As an alterna...
Article
Importance: Anticonvulsant mood stabilizer treatment is associated with an increased risk of weight gain, but little is known about the risk of developing type 2 diabetes (T2D). Objective: To evaluate the comparative safety of anticonvulsant mood stabilizers on risk of T2D in adults and children by emulating a target trial. Design, setting, and...
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We introduce optimal regimes for algorithm-assisted human decision-making. Such regimes are decision functions of measured pre-treatment variables and enjoy a "superoptimality" property whereby they are guaranteed to outperform conventional optimal regimes currently considered in the literature. A key feature of these superoptimal regimes is the us...
Article
Objective: The authors sought to determine the association of cannabis indicators with self-reported psychotic disorders in the U.S. general population. Methods: Participants were from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC; 2001-2002; N=43,093) and NESARC-III (2012-2013; N=36,309). Logistic regression was us...
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Objective To determine whether emotional and physical intimate partner violence (IPV) and financial adversity increase risk of incident homelessness in pregnancy and the post-partum period. Study design Data were drawn from the Avon Longitudinal Study of Parents and Children, which starting in 1990 mailed questionnaires to 14,735 mothers in the UK...
Article
Despite the burden of sexual assault on college campuses, few effective prevention programs exist. Understanding the socio-ecological context in which sexual assaults occur may illuminate novel pathways to augment prevention. We examined data from 349 students at two inter-connected urban universities who completed a population-based survey ( N = 1...
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Objective: To determine the association of cannabis use-related variables and self-reported psychotic disorders during two time periods (2001-2002; 2012-2013). Methods: Logistic regression was used to analyze data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, 2001-2002; N=43,093) and NESARC-III (2012-2013; N=36,3...
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Objectives Research examining sex among college students has frequently focused on negative sexual experiences. This study aimed to understand situational predictors of various dimensions of students’ sexual experiences. Methods: 427 college students participated in a 60-day daily survey; 213 reported sex and were asked questions about each sexual...
Article
Partial exchangeability is sufficient for the identification of some causal effects of interest. Here we review the use of common graphical tools and the sufficient component cause model in the context of partial exchangeability. We illustrate the utility of single world intervention graphs (SWIGs) in depicting partial exchangeability and provide a...
Article
Aims: Medical marijuana law (MML) enactment in the United States has been associated with increased cannabis use but lower traffic fatality rates. We assessed the possible association of MML and individual-level driving under the influence of cannabis (DUIC) and also under the influence of alcohol (DUIA). Design and setting: Three cross-sectiona...
Preprint
Investigators often evaluate treatment effects by considering settings in which all individuals are assigned a treatment of interest, assuming that an unlimited number of treatment units are available. However, many real-life treatments may be constrained and cannot be provided to all individuals in the population. For example, patients on the live...
Article
Objective: Given changes in U.S. marijuana laws, attitudes, and use patterns, individuals with pain may be an emerging group at risk for nonmedical cannabis use and cannabis use disorder. The authors examined differences in the prevalence of nonmedical cannabis use and cannabis use disorder among U.S. adults with and without pain, as well as wheth...
Article
Background: Due to significant comorbidity and impairment associated with cannabis use and cannabis use disorder, understanding time trends in cannabis use and cannabis use disorder is an important public health priority. Objectives: To identify trends in cannabis use and cannabis use disorder overall, and by sociodemographic subgroup. Methods: Nar...
Article
The primary aim of the current study was to examine the prevalence and correlates of self-reported sexual assault (SA) perpetration, defined as nonconsensual sexualized touching or attempted or completed oral, vaginal, or anal penetration since starting college among men, women, and gender nonconforming (GNC) students. A secondary aim was to examin...
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Background: Research has documented multilevel risk factors associated with experiencing incapacitated sexual assault among undergraduate women. Less is known about multilevel risk factors associated with nonincapacitated sexual assault. This study examines and compares the different settings, coercion methods, and relationships in which incapacit...
Article
Cognitive impairments are associated with poor outcomes when treating cocaine dependent patients, but behavioral interventions to mitigate this impact have not been developed. In this Stage 1A/1B treatment development study, several compensatory strategies (e.g., content repetition, daily logs, diaries, visual presentation) were combined to create...
Data
Table S1 Basic characteristics of studies—excluded from meta‐analysis, published in peer‐reviewed journals. Table S2 Results and basic characteristics of studies excluded from the meta‐analysis because they were not published in peer‐reviewed journals. Table S3 Primary model specifications of meta‐analyzed studies.
Article
Background: Prescription drug monitoring programs (PDMPs) are a key component of the president's Prescription Drug Abuse Prevention Plan to prevent opioid overdoses in the United States. Purpose: To examine whether PDMP implementation is associated with changes in nonfatal and fatal overdoses; identify features of programs differentially associa...
Article
Objective: Adult cannabis use has increased in the United States since 2002, particularly after 2007, contrasting with stable/declining trends among youth. We investigated whether specific age groups disproportionately contributed to changes in daily and nondaily cannabis use trends. Method: Participants ages 12 and older (N = 722,653) from the...
Article
Background: National trends in adolescent's marijuana risk perceptions are traditionally used as a predictor of concurrent and future trends in adolescent marijuana use. We test the validity of this practice during a time of rapid marijuana policy change. Methods: Two repeated cross-sectional U.S. nationally-representative surveys of 8th, 10th,...
Article
Background: Self-medication with drugs or alcohol is commonly reported among adults with mood or anxiety disorders, and increases the risk of developing substance use disorders. Medical marijuana laws (MML) may be associated with greater acceptance of the therapeutic value of marijuana, leading individuals to self-medicate. Methods: The study ut...
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Aims: To conduct a systematic review and meta-analysis of studies in order to estimate the effect of US medical marijuana laws (MMLs) on past-month marijuana use prevalence among adolescents. Methods: A total of 2999 papers from 17 literature sources were screened systematically. Eleven studies, developed from four ongoing large national surveys...
Article
Importance No US national data are available on the prevalence and correlates of DSM-5–defined major depressive disorder (MDD) or on MDD specifiers as defined in DSM-5. Objective To present current nationally representative findings on the prevalence, correlates, psychiatric comorbidity, functioning, and treatment of DSM-5 MDD and initial informat...
Article
Background: Historical shifts have taken place in the last twenty years in marijuana policy. The impact of medical marijuana laws (MML) on use of substances other than marijuana is not well understood. We examined the relationship between state MML and use of marijuana, cigarettes, illicit drugs, nonmedical use of prescription opioids, amphetamine...
Data
Number of incidents of sexual assault since enrolling at CU/BC, among individuals with at least one incident. (DOCX)
Article
Full-text available
Sexual assault on college campuses is a public health issue. However varying research methodologies (e.g., different sexual assault definitions, measures, assessment timeframes) and low response rates hamper efforts to define the scope of the problem. To illuminate the complexity of campus sexual assault, we collected survey data from a large popul...
Article
Cannabis is widely used among adolescents and adults. In the U.S., marijuana laws have been changing, and Americans increasingly favor legalizing cannabis for medical and recreational uses. While some can use cannabis without harm, others experience adverse consequences. The objective of this review is to summarize information on the legal status o...
Article
Importance Over the last 25 years, illicit cannabis use and cannabis use disorders have increased among US adults, and 28 states have passed medical marijuana laws (MML). Little is known about MML and adult illicit cannabis use or cannabis use disorders considered over time. Objective To present national data on state MML and degree of change in t...
Article
Importance: Heroin use is an urgent concern in the United States. Little is know about the course of heroin use, heroin use disorder, and associated factors. Objective: To examine changes in the lifetime prevalence, patterns, and associated demographics of heroin use and use disorder from 2001-2002 to 2012-2013 in 2 nationally representative sam...
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Full-text available
PurposeWhile gender inequality has been a topic of concern for decades, little is known about the relationship between gender discrimination and illicit drug use. Further, whether this association varies by education level is unknown. Methods Among 19,209 women participants in Wave 2 of the National Epidemiologic Survey on Alcohol and Related Condi...
Article
Aims In HIV-infected individuals, non-injection drug use (NIDU) compromises many health outcomes. In HIV primary care, the efficacy of brief motivational interviewing (MI) to reduce NIDU is unknown, and drug users may need greater intervention. We designed an enhancement to MI, HealthCall (HC), for daily patient self-monitoring calls to an interact...
Article
Importance: Historical shifts are occurring in marijuana policy. The effect of legalizing marijuana for recreational use on rates of adolescent marijuana use is a topic of considerable debate. Objective: To examine the association between the legalization of recreational marijuana use in Washington and Colorado in 2012 and the subsequent perceiv...
Article
Full-text available
Aim: Concurrently with increasingly permissive attitudes towards marijuana use and its legalization, the prevalence of marijuana use has increased in recent years in the U.S. Substance use is generally more prevalent in men than women, although for alcohol, the gender gap is narrowing. However, information is lacking on whether time trends in mari...
Article
Background: Heavy alcohol consumption can be harmful, particularly for individuals with HIV. There is substantial variability in response to interventions that aim to reduce drinking. Neighborhood drinking norms may explain some of this variability among HIV-infected patients. Therefore, we investigated whether neighborhood-level drinking norms mo...
Article
Purpose of review: Illicit drugs, alcohol, and tobacco use disorders contribute substantially to the global burden of disease. Knowledge about the major elements of the natural history of substance use disorders (incidence, remission, persistence, and relapse) is crucial to a broader understanding of the course and outcomes of substance use disord...

Citations

... Fortunately, biomedical ontologies contain authoritative, expert-curated representations of entities and relationships between those entities that are exploitable by computer programs. Causal knowledge in these ontologies has been used to inform causal models in AD research 35 and elsewhere [36][37][38][39][40] . This knowledge could be used to filter out erroneous assertions from machine reading. ...
... Indeed, recent increases in mainstream media coverage of adverse effects of cannabis use among adolescents and young adults has reignited concerns over problems such as psychosis and cannabis hyperemesis [8][9][10][11][12], which are known to be associated with frequent or chronic use [13,14]. Furthermore, a recent study on the effects of cannabis legalization in the US found that cannabis legalization led to significantly higher risk of self-reported past-year cannabis use among a sample of 10-20 year old youth [15]. ...
... Second, as a result of the low retention rate, the sample size of the study was relatively small, which prevented us from capturing a sufficient number of participants who only experienced IPV three years after childbirth but not before pregnancy, during pregnancy, or 4 weeks after childbirth. Future studies are suggested to explore the experience of this group of women, as partners may generally be less physically violent because it can harm the baby [46], while emotional IPV may not decrease [47]. Lastly, our results may not be generalizable to other contexts, as various cultural and ethnic factors may lead to different attitudes toward IPV. ...
... Although it is possible that women's assertions of sexual agency threaten men's sense of masculinity leading to additional coercion and violence, it can be argued that instilling beliefs of gender equality in early childhood sexual education would attenuate these feelings of threat among men in adulthood. In sum, although sexual communication in general can enhance sexual pleasure and emotional intimacy between partners (Mallory et al., 2019;Wilson et al., 2020), communication of sexual consent withdrawal could also be discussed as enhancing or signifying healthy sexual relationships and sexual pleasure. This study offers further support for the inclusion of sexual pleasure in education as a way of promoting ongoing consent communication during sexual encounters. ...
... at the level of the encounter, which could augment our ecological understanding of how different dimensions of internal and external consent are experienced together. Latent class or profile analyses have been used to better understand the characteristics of unwanted sexual experiences (e.g., French et al., 2014;Walsh et al., 2021a) and sexual risk behaviors (e.g., Danielson et al., 2014;Vasilenko et al., 2015), but to our knowledge has not been applied to consent feelings and behaviors during a consensual encounter. We also examined how these profiles relate to individual, interpersonal, and event-related characteristics. ...
... One such study utilizing Danish health records linked an increase in cannabis-induced psychosis since 2006 to an increase in both frequency of use and THC concentration over time [77]. A recent study using NESARC and NESARC-III data showed that participants reporting that a doctor or other health professional told them they had schizophrenia or a psychotic episode were more likely to be frequent cannabis users and have a current CUD diagnosis than other participants [103]. ...
... Two studies found no difference in attitudes and beliefs concerning DUIC between residents of U.S. states with medical cannabis legalization and those without. 33,70 Three studies found an association between legalization and greater self-reported DUIC, 33,34,47 with 1 study noting that the finding was not consistent across all time periods and states, 47 whereas a fourth study found lower self-reported DUIC associated with retail sales. 35 Positive cannabis, alcohol, and other drug tests among drivers and patients with trauma. ...
... We use Single World Intervention Graphs (SWIGs) to represent the assumptions about the underlying process that produces outcomes under a grace period strategy (Richardson and Robins, 2013). SWIGS, unlike more traditional causal directed acyclic graphs (DAGs), explicitly depict counterfactual variables which makes them better suited for reasoning about exchangeability conditions, which directly concern counterfactual independencies (Shpitser et al., 2020;Sarvet et al., 2020). SWIGs are particularly illuminating in the case of treatment strategies that depend on natural treatment values, such as the natural grace period treatment strategies we consider here, allowing explicit depiction of both natural (e.g. ...
... These changes in the socio-demographic profile of people who use cannabis may result in shifts over time in the proportion of people who use cannabis who go on to develop CUD [73]. For example, recent studies suggest that older adults who use cannabis are increasingly less likely to develop CUD than young adults [69••], whereas those with chronic pain who use cannabis, for which cannabis is often taken medicinally, are increasingly more likely to develop CUD [111]. Although evidence is currently unclear as to how CUD prevalence may be a function of changes in the demographic makeup of people who use cannabis, it is possible that such changes may influence rates of CUD and, consequently, CUD treatment utilization trends. ...
... It was surprising that lower-income individuals, those with lower educational attainment, and individuals with no health insurance were less likely to be exposed to CME, given that these individuals are more likely to report current cannabis use. 24 They may have been more likely to live in T A B L E 3 Linear and logistic regression models of associations of cannabis marketing exposure with attitudes and use behavior in the full sample. rural areas, and thus less likely to be exposed to outdoor marketing, as marketing tends to cluster in densely populated areas. ...