A.G. Ferrige's scientific contributions

Publications (2)

Article
Endothelium-derived relaxing factor (EDRF) is a labile humoral agent which mediates the action of some vasodilators. Nitrovasodilators, which may act by releasing nitric oxide (NO), mimic the effect of EDRF and it has recently been suggested by Furchgott that EDRF may be NO. We have examined this suggestion by studying the release of EDRF and NO fr...

Citations

... NO, as a simple gaseous small molecule, can easily diffuse through the cell membrane and plays an important role in the organisms (Calabrese et al. 2009;Li et al. 2018). NO was reported to be synthesized in mammals and involved in many physiological processes of plant, such as seed germination, growth, stomatal movement, photosynthesis, respiration, cell transportation, cell death, immune system, and stress response (Palmer et al. 1987;Takahashi and Yamasaki, 2002;Guo and Crawford, 2005;Floryszak-Wieczorek and Arasimowicz-Jelonek, 2016;Fu et al. 2016;Oliveira et al. 2016;Wang et al. 2017). Macrofungi, a multicellular organism, have many characteristics different from plants and animals. ...
... Ferid Murad was awarded the Nobel Prize in Physiology or Medicine in 1998 for his finding on cyclic guanosine monophosphate (GMP) dependence.In his early findings, NO was shown to activate the cytoplasmic isoform of guanylyl cyclase, which catalyzes the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (GMP). In these circumstances, the increase of GMP level will lead to a series of phosphorylation processes, thereby causing the dilation of blood vessels and the change of blood flow velocity (15). This pathway is known as the GMP-dependent pathway. ...