A. Woodiwiss's research works | University of the Witwatersrand, Johannesburg (wits) and other places

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THU0136 NESFATIN-1 expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis

Conference Paper

Jun 2017

Background Nesfatin-1 comprises a peptide that is involved in appetite suppression, energy homeostasis and fluid regulation, and was recently documented to participate in a range of cardiometabolic pathways (1,2). There is currently a need for the identification of novel biomarkers in the elucidation of CVD risk and its stratification in persons wi...

FRI0170 Cardiovascular risk factors and disease characteristics are consistently associated with arterial stiffness in rheumatoid arthritis

Conference Paper

Jun 2017

Background In the non-rheumatoid arthritis (RA) population, arterial stiffness contributes to cardiovascular disease risk beyond brachial blood pressure and other established cardiovascular risk factors. The increased cardiovascular disease risk in RA is now well documented. In this regard, how RA impacts on arterial stiffness remains uncertain. O...

[PP.11.06] ASSOCIATION BETWEEN AORTIC BACKWARD WAVE PRESSURES, BUT NOT AORTIC STIFFNESS AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN A YOUNG-TO-MIDDLE-AGED COMMUNITY SAMPLE.

Article

Sep 2016

[PP.37.01] TIME TO PEAK OF THE AORTIC FORWARD WAVE DETERMINES THE IMPACT OF AORTIC BACKWARD WAVE AND PULSE PRESSURES ON LEFT VENTRICULAR MASS

Article

Sep 2016

[PP.15.07] ASSOCIATION OF BLOOD PRESSURE VARIABILITY RATIO WITH GLOMERULAR FILTRATION RATE INDEPENDENT OF BLOOD PRESSURE AND PULSE WAVE VELOCITY

Article

Sep 2016

OP.8A.02] POST-EXERCISE EFFECTS ON AORTIC WAVE REFLECTION DERIVED FROM WAVE SEPARATION ANALYSIS IN PRE-HYPERTENSIVES AND HYPERTENSIVES: COMPARISON WITH CHANGES IN AUGMENTATION INDEXES

Conference Paper

Sep 2016

Objective: Decreases in brachial blood pressure (BP) may occur for several hours following a bout of exercise. Although aortic backward waves predict cardiovascular damage independent of brachial BP, whether decreases in aortic backward waves also occur post-exercise; the extent to which these changes exceed brachial BP changes; and the best metho...

7A.07: LIMITED CONTRIBUTION OF OBESITY TO VARIATIONS IN OFFICE, AMBULATORY AND AORTIC BLOOD PRESSURES IN A BLACK AFRICAN COMMUNITY WITH PREVALENT OBESITY AND HYPERTENSION

Article

Jun 2015

Obesity causes an increased blood pressure (BP). This effect may be diminished in communities of African descent. However, the impact of obesity on ambulatory or aortic BP, which are enhanced in groups of African ancestry, has not been assessed. We aimed to determine the extent to which obesity is related to variations in office, ambulatory and aor...

4D.08

Article

Jun 2015

Objective: Although the pro-fibrotic inflammatory substance galectin-3 predicts outcomes in the general population, the mechanisms responsible for this effect are uncertain. As galectin-3 expression contributes to aortic stiffness in preclinical studies, we aimed to determine whether circulating galectin-3 concentrations are associated with carotid...

4D.03

Article

Jun 2015

Objective: Although aortic augmentation index (AIx) and pressure (Pa) are inherited, AIx and Pa are poor measures of reflected (backward) wave function. As wave reflection predicts outcomes beyond brachial BP, we aimed to determine the intra-familial aggregation and heritability of indices of aortic wave reflection derived from wave separation anal...

PP.20.06

Article

Jun 2015

Objective: Aortic blood pressure (BP) predicts outcomes and is associated with end-organ measures independent of brachial BP. Whether this is accounted for by the impact of aortic forward or backward waves on variations in aortic-to-brachial BP amplification is uncertain. We aimed to determine whether brachial BP-independent relations between aorti...

LEPR HAPLOTYPES ARE ASSOCIATED WITH SYSTOLIC BLOOD PRESSURE IN BLACK SOUTH AFRICAN MEN

Article

Jul 2014

SAT0070 Towards Adipokine Inhibition in Rheumatoid Arthritis: Is Adiponectin Inhibition Expected to Enhance Cardiovascular Metabolic Risk and Atherosclerosis?

Article

Jan 2014

Background Leptin and particularly adiponectin are likely involved in the pathophysiology of rheumatoid arthritis (RA) and therefore potential new therapeutic targets. In the general population, leptin enhances and adiponectin reduces cardiovascular metabolic risk. Hence, adiponectin inhibition would be expected to result in increased cardiovascula...

SAT0043 Potential Determinants of Atherogenesis in Patients with Rheumatoid Arthritis from Two Population Groups

Article

Jun 2013

Background The very early steps in atherosclerosis comprise adhesion of monocytes to the endothelium and monocyte transmigration through the endothelial barrier into the intima. These processes are effectuated by adhesion molecules and monocyte chemoattractant protein-1 (MCP-1), a molecule that plays a unique and crucial role in early atheroscleros...