A T Sandison’s research while affiliated with University of Glasgow and other places

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Publications (16)


Histiocytosis in 2 Pigs and a Cow - Conditions Resembling Lipid Storage Disorders in Man
  • Article

March 1970

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2 Reads

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18 Citations

The Journal of Pathology

A T Sandison

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Lindsay J. Anderson




Tumours of the Female Genitalia in Cattle, Sheep and Pigs found in a British Abattoir Survey

February 1969

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37 Reads

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60 Citations

Journal of Comparative Pathology

A histological survey was made of all neoplasms found in slaughtered cattle, sheep and pigs during one year in 100 abattoirs throughout Great Britain. The specimens collected comprised 302 tumours from cattle, 107 from sheep and 139 from pigs. Twenty female genital tumours were found in cattle, 2 in sheep and 6 in pigs. Ovarian tumours included granulosa-cell tumours, a combined granulosa-cell tumour and teratoma, papillary serous cystadenocarcinomas, mucinous cystadenocarcinomas, an adeno-acanthoma and simple mesenchymal tumours. All specimens from the body of the uterus were mesenchymal tumours, usually of smooth muscle. Squamous carcinomas of the ectocervix and a vaginal fibroma occurred in cattle. The incidence and histological appearances are reported, with reference to the characteristics of human female genital neoplasms.


Tumours of the endocrine glands in cattle, sheep and pigs found in a British abattoir survey

November 1968

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17 Reads

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24 Citations

Journal of Comparative Pathology

A histological survey has been made of all neoplasms, except those of the brain and pituitary, found in slaughtered cattle, sheep and pigs during one year in 100 abattoirs throughout Great Britain. The specimens collected comprised 302 tumours from cattle, 107 from sheep and 139 from pigs: of these, 35 bovine, 3 ovine and 3 porcine tumours originated in endocrine glands (other than the ovary). The majority were tumours of the adrenal cortex, which were encountered in all three species. Phaeochromocytomas also occurred in each species. Less common tumours of the thyroid gland and pancreatic islets were included in the series. In this paper, the incidence of such tumours is indicated and the histological appearances are described. The findings are considered in relation to the characteristics of the corresponding neoplasms in man.



Tumors of the kidney in cattle, sheep and pigs

May 1968

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41 Reads

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26 Citations

Cancer

This paper describes the incidence and histopathology of primary tumors of the kidney in slaughtered cattle, sheep and pigs encountered during a 12-month survey of all neoplasms found in 100 abattoirs throughout Great Britain. A total of 302 bovine, 107 ovine and 139 porcine tumors were examined. In cattle 11 (3.6%) were primary renal tumors (8.5 per million animals). In sheep 4 (3.7%) were renal tumors (0.9 per million animals) while in pigs the results were 16 (11.5%) and 4.3 per million. Secondary tumors involving the kidney outnumbered primaries in all species. The most common secondary tumor was lymphosarcoma. Histologically most bovine primary renal tumors were carcinomas—clear cell' carcinomas, tubular and papillary adenocarcinomas or pleomorphic acidophilic carcinomas. These were not separate types, however, and a transition from the clear cell to the tubular and papillary forms was apparent in many. In sheep all four specimens were renal carcinomas; a similar transition between variants was observed. In pigs most renal tumors were nephroblastomas, showing all of the well-known features of this neoplasm. Many renal carcinomas had metastasized, usually to the renal and sublumbar lymph nodes and sometimes involving lung, liver, peritoneum and bronchomediastinal lymph nodes. There was no evidence of any sex predisposition to renal neoplasia and no association between tumors of the kidney and the presence of any other renal disease.


Pulmonary tumours found in a British abattoir survey: primary carcinomas in cattle and secondary neoplasms in cattle, sheep and pigs
  • Article
  • Full-text available

April 1968

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37 Reads

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18 Citations

British Journal of Cancer

The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to encourage communication of the very best cancer research from laboratories and clinics in all countries. The breadth of its coverage, its editorial independence and it consistent high standards, have made BJC one of the world's premier general cancer journals. Its increasing popularity is reflected by a steadily rising impact factor.

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Tumors of the liver in cattle, sheep and pigs

March 1968

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121 Reads

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42 Citations

Cancer

This paper describes a series of primary tumors of the liver parenchyma and biliary tract in cattle, sheep and pigs which were examined during a 12-mouth survey of neoplasms found in 100 abattoirs throughout Great Britain. In cattle 302 tumors were studied, 36 of which arose in the liver. Cholangiocarcinomas outnumbered liver cell tumors. In sheep 32 of 107 tumors originated in the liver, with liver cell tumors more numerous than cholangiocarcinomas. Primary liver tumors were of a comparatively low incidence in pigs—only six in 139 neoplasms. There were no cholangiocarcinomas in pigs though one adencarcinoma of the gallbladder was found. Secondary tumors outnumbered primary liver tumors in cattle and pigs while the converse was true in sheep. Of the secondary tumors involving liver, lymphosarcoma predominated in the three species. Malignancy of liver cell tumors was difficult to assess in the absence of obvious metastases; however, most of the liver cell tumors were apparently benign while the great majority of the cholangiocarcinomas had metastasized to lymph nodes, peritoneum and lung. There was no significant association between primary hepatic tumours and the presence of any pre-existing disease process.


Citations (15)


... Pheochromocytomas are the most common neoplasms arising in the adrenal medulla of animals, and they develop most frequently in cattle and dogs, rarely in other domestic animals, and are extremely rare in swine [78,79]. In a survey carried out in slaughterhouses of 3.7 million pigs in the UK, only a 2.5-year-old female was diagnosed with pheochromocytoma, which shows a low incidence in pigs probably due to the fact that many animals are slaughtered before reaching maturity [80]. ...

Reference:

Neoplasms in Domestic Ruminants and Swine: A Systematic Literature Review
Tumours of the endocrine glands in cattle, sheep and pigs found in a British abattoir survey
  • Citing Article
  • November 1968

Journal of Comparative Pathology

... The slides were then incubated for 1 hour at room temperature with the following primary antibodies: mouse monoclonal anti-smooth muscle actin (SMA) 1:1,000 (clone 1A4, Dako, Glostrup, Denmark), rabbit polyclonal anti-glial fibrillary acidic protein (GFAP) 1:10,000 (Dako, Glostrup, Denmark), rabbit polyclonal anti-CD3 1:300 (Dako, Glostrup, Denmark), rabbit polyclonal anti-CD20 1:250 (Thermo Fisher Scientific, Freemont, CA, USA), mouse monoclonal anti-cytokeratin 1:250 (clone AE1/AE3, Dako, Glostrup, Denmark), rabbit investigation of selected lesions (Alvarez et al. 1982, Lucena et al. 2011, Marosfoi et al. 2008, Murray 1968, Naghshineh et al. 1991. The prevalence of tumors is extremely low and variable in surveys conducted in slaughtered cattle, ranging from 23 per 100,000 to 227 per 100,000 cattle (Anderson et al. 1969, Brandly and Migaki 1963, Misdorp 1967, Reisinger 1963. The most commonly reported tumors are lymphoma and ocular squamous cell carcinoma (Anderson et al. 1969, Bastianello 1982, Brandly and Migaki 1963, Cotchin 1960, Dukes et al. 1982, Monlux et al. 1956, Murray 1968, Naghshineh et al. 1991, Plummer 1956, Priester and Mantel 1971, Reisinger 1963, Russell et al. 1956, Sastry and Twiehaus 1964, Shortridge and Cordes 1971. ...

A British abattoir survey of tumours in cattle, sheep and pigs
  • Citing Article
  • June 1969

The Veterinary record

... Several abattoir surveys reviewed the different neoplasms found in slaughtered domestic animals and their incidence in the past 50 years. In the late 1960s, a large histologic survey of neoplasms in slaughtered animals was carried out throughout 100 abattoirs in Great Britain, which led to a comprehensive description of neoplastic lesions in swine, bovine and sheep including the type of neoplasm and incidence encountered per organ [3,[17][18][19][20][21][22][23]. Previously, in 1963, Brandly and Migaki presented a 8-year survey which described different neoplasms detected in domestic animals slaughtered in the United States [24]. ...

Tumours of connective tissues in cattle, sheep and pigs
  • Citing Article
  • August 1969

The Journal of Pathology

... Several abattoir surveys reviewed the different neoplasms found in slaughtered domestic animals and their incidence in the past 50 years. In the late 1960s, a large histologic survey of neoplasms in slaughtered animals was carried out throughout 100 abattoirs in Great Britain, which led to a comprehensive description of neoplastic lesions in swine, bovine and sheep including the type of neoplasm and incidence encountered per organ [3,[17][18][19][20][21][22][23]. Previously, in 1963, Brandly and Migaki presented a 8-year survey which described different neoplasms detected in domestic animals slaughtered in the United States [24]. ...

Tumors of the liver in cattle, sheep and pigs
  • Citing Article
  • March 1968

Cancer

... The canine model developed ataxia and trembling and survived to 8 months of age; a breeding colony was not established (34). The disease in a pig was identified through tissue samples submitted via meat inspection and was not further characterized or captured (35). The ovine model develops tremors and paraparesis and dies within a few days. ...

Histiocytosis in 2 Pigs and a Cow - Conditions Resembling Lipid Storage Disorders in Man
  • Citing Article
  • March 1970

The Journal of Pathology

... It is usually seen in fully developed breast during 15-25 years' period (Bailey and Love). As per Evans (15-25 yrs.) age group is the commonest 5 and according to Sandison maximum incidence in 21-35 years' age group 6 Haque et al showed in his study that 80% patients are below 30 years. 7 Youngest patient was of 14 years and oldest 55 years. ...

Diseases of the adolescent female breast. A clinico-pathological study
  • Citing Article
  • June 1968

BJS (British Journal of Surgery)

... 30 In cattle, studies on the frequency of these neoplasms are scarce and are usually comprised of incidental findings from slaughterhouses. 4,46 The reported frequency of primary pulmonary tumors in cattle varies 8.3% in England, 4 0.86% in the Netherlands, 35 and 0.32% to 0.68% in southern Brazil. 31,49 Primary epithelial pulmonary neoplasms may arise from alveolar cells, bronchial glands, or bronchiolar epithelium. ...

Pulmonary tumours found in a British abattoir survey: primary carcinomas in cattle and secondary neoplasms in cattle, sheep and pigs

British Journal of Cancer

... Like in many other neoplasias, the incidence of uterine tumors increases significantly with the age of the animals. This could be the reason why tumors are rarely diagnosed in farm animals, which are slaughtered at a relatively young age [6] [7]. It has been described that in 32 female, ovariohysterectomized minipigs, uterine lesions, such as cystic endometrial hyperplasia, leiomyoma, leiomyosarcoma, adenocarcinoma, adenoma and adenomyosis were more often found in older animals [8]. ...

Tumours of the Female Genitalia in Cattle, Sheep and Pigs found in a British Abattoir Survey
  • Citing Article
  • February 1969

Journal of Comparative Pathology

... Several abattoir surveys reviewed the different neoplasms found in slaughtered domestic animals and their incidence in the past 50 years. In the late 1960s, a large histologic survey of neoplasms in slaughtered animals was carried out throughout 100 abattoirs in Great Britain, which led to a comprehensive description of neoplastic lesions in swine, bovine and sheep including the type of neoplasm and incidence encountered per organ [3,[17][18][19][20][21][22][23]. Previously, in 1963, Brandly and Migaki presented a 8-year survey which described different neoplasms detected in domestic animals slaughtered in the United States [24]. ...

Tumors of the thymus in cattle, sheep, and pigs
  • Citing Article
  • June 1969

Cancer Research