A Skevas's research while affiliated with University of Ioannina and other places
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Publications (72)
The present study describes the audiological profile of genetic hearing loss resulting from GJB2 mutations in northern Greece, as this represents the most frequent single cause of childhood sensorineural hearing loss. The 35delG mutation in homozygosity was detected in 27 of 107 patients (25.2%). The audiological profile is that of a profound or se...
We investigated whether modeling with artificial neural networks or logistic regression of distortion product otoacoustic emissions (DPOAE), across diverse frequencies, may achieve an accurate diagnosis of sensorineural hearing loss (SNHL) of cochlear origin. 256 ears (90 with SNHL and 166 with normal hearing) were evaluated with pure-tone audiomet...
The infratentorial variety of the subdural empyema, with or without coexisting cerebellar abscess, is a rare clinical entity that carries a high mortality rate. We briefly describe the case of a 49-year-old man presented with severe debility, fever and an obviously neglected chronic otitis media. The patient had refused surgical treatment several m...
In order to reduce the examination time of the Distortion Product Otoacoustic Emissions (DPOAE) test, we investigated the applicability of the multiple-tone pairs method by comparing the DPOAE evoked by 4- and 3-tone pairs (Sim) with the conventional 1-tone pair (Seq) in 116 ears of human adults with normal hearing (NH) and 86 ears with sensorineur...
Air bag safety systems have significantly reduced the number of occupant injuries from road traffic accidents (RTA). However air bag deployment is also associated with unavoidable risks.
We report the acoustic trauma incurred by a young female driver who was a heavy smoker as a consequence of air-bag deployment in a low speed RTA and the sparing of...
Solitary extramedullary plasmacytomas are rare tumors that often affect head and neck region. Because of the non-specific associated symptomatology, they frequently are misdiagnosed. We briefly describe a 69-year-old woman who developed solitary plasmacytoma in the left maxillary sinus and was initially treated as having sinusitis. We also report t...
Pseudomonas (P) aeruginosa has been rarely reported as a causative agent of chronic sinusitis in otherwise healthy individuals, mostly as part of polymicrobial infections, while it has been frequently described among immunocompromised patients. We report a case of chronic maxillary sinustitis due to P. aeruginosa presenting as recurrent facial pain...
The aim of this study was to investigate the influence of weather conditions on the frequency of acute laryngitis in adults. The medical records of 825 patients with a diagnosis of acute laryngitis obtained over a 5-year period were reviewed. Meteorological data reviewed included the daily values of 13 parameters. The monthly distribution of the di...
Mutations in the gene encoding the gap junction protein connexin 26 (GJB2) have been shown as a major contributor to prelingual, sensorineural, nonsyndromic, recessive deafness. One specific mutation, 35delG, has accounted for the majority of the mutations detected in the GJB2 gene in Caucasian populations. The aim of our study was to determine the...
Mutations in the gene encoding the gap-junction protein connexin 26 (GJB2) on chromosome 13q11 have been shown as a major contributor to prelingual, sensorineural, nonsyndromic deafness. One specific mutation, 35delG, has accounted for the majority of the mutations detected in the GJB2 gene in Caucasian populations and is one of the most frequent d...
Background
Climatic or meteorological condition changes have been implicated in the pathogenesis of Idiopathic Sudden Sensorineural Hearing Loss (ISSHL). We investigated the seasonal distribution of ISSHL and evaluated the influence of meteorological parameters (such as temperature, humidity, and atmospheric pressure), their variation and covariati...
This retrospective study aims to search out the influence of temperature, atmospheric pressure and humidity on the frequency of epistaxis. The study includes 701 patients who have suffered from epistaxis and have been treated in the ENT department of the University of Ioannina Hospital, during the years 1995 and 1996. The statistical methods used a...
According to various authors the incidence of multiple primary tumors in the aerodigestive tract can be considered high. However, most of these tumors are metachronous and of the same histological type. The occurrence of a small cell lung carcinoma synchronous with a squamous cell vocal cord carcinoma is a very rare phenomenon. In this report we pr...
Ear damage in systemic lupus erythematosus (SLE) patients has been occasionally reported but the frequency and the mechanisms of ear involvement are not well documented. In an attempt to investigate the presence of hearing loss and the possible causes for it we prospectively evaluated 43 SLE patients. All patients underwent a complete ear-nose-thro...
Background
Climatic or meteorological condition changes have been implicated in the pathogenesis of Bell's palsy (BP). We evaluate the influence of meteorological parameters, such as temperature, humidity, and atmospheric pressure, and their variation and covariation on the incidence of BP and present a review of the literature on the effect of met...
To investigate the middle and inner ear involvement in patients with progressive systemic sclerosis (PSS).
We prospectively evaluated 34 PSS patients. All patients underwent a complete ear-nose-throat physical examination and audiological evaluation with pure tone, impedance, and speech audiometry. In addition, systemic manifestations of the diseas...
An unusual case of recurrent tonsillitis due to pseudomonas aeruginosa. Pseudomonas (P.) aeruginosa in the head and neck region of an immunocompetent patient is mainly seen in ear infections, and sometimes in sinusitis. P. aeruginosa is an occasional finding in tonsil smears as part of normal microbial flora, but it rarely produces suppurative tons...
Chronic sinusitis, especially maxillary sinusitis is a common disorder in humans. Seromucous sinusitis is rarely described in the literature. The present study deals with the clinical and laboratory characteristics of a group of patients suffering from the above disorder. During the last 10 years, 32 patients suffering from seromucous maxillary sin...
Objectives: The purpose of this study was to investigate the seasonal and epidemic distribution of the disease in the environment of Ioannina prefecture, with a population of 158,000 and a climate of a transitive zone between Mediterranean and continental. Patients: This retrospective study included 125 patients suffering from idiopathic peripheral...
To estimate the diagnostic accuracy and reliability of exfoliative laryngeal cytology.
Over three years (1996-1999) cytologic smears were obtained from clinically suspicious laryngeal lesions during laryngoscopy in a total of 31 selected patients (28 males and 3 females with an age range from 28-90 years). The cytologic diagnoses were analyzed and...
In an attempt to investigate the presence of hearing loss in primary Sjögren's syndrome (SS) patients and to determine the factors that might be involved in its pathogenesis, we prospectively evaluated 45 female SS patients with a mean age of 56.8 +/- 9.23 years and a mean disease duration of 8.32 +/- 5.39 years.
Forty patients underwent a complete...
p53 is a nuclear phosphoprotein acting as a transcription factor to regulate cell cycle progression and apoptosis, mediated by a number of target genes. p53 mutant proteins have lost a) the ability to act as sequence-specific transcription factors and b) their tumour suppressive properties. As p53 is the most commonly mutated gene in human cancer,...
Tenascin (TN) is an extracellular matrix glycoprotein expressed in areas of epithelial-mesenchymal interactions during embryogenesis and in neoplasia. We studied the expression of TN in a series of 35 squamous cell invasive carcinomas of the larynx, 13 in situ carcinomas, 41 cases of dysplasia, 10 papillomas and 18 cases of keratosis using the mono...
Focal epithelial hyperplasia (FEH) or Heck disease, is a rare viral infection of the oral mucosa caused by HPV 13 or HPV 32. In Caucasians there have been only a few cases reported. We present the first case in Greece in a young Caucasian girl in which HPV 13 was detected with PCR analysis. The patient was successfully treated with CO2 laser.
Mutations in the gene encoding the gap-junction protein connexin 26 (GJB2) on chromosome 13q11 have been shown as a major contributor to prelingual, sensorineural, nonsyndromic deafness. One specific mutation, 35delG, has accounted for the majority of the mutations detected in the GJB2 gene in Caucasian populations and is one of the most frequent d...
Accelerated tumor repopulation during fractionated radiation therapy is considered an important cause of treatment failure. In everyday clinical practice this phenomenon is mostly associated with prolonged duration of the radiation treatment. However, other factors such as cell oxygenation status during radiation therapy and radiation-induced chang...
CD44 is an integral membrane glycoprotein that has diverse functions in cell-cell and cell-substrate interactions. It has been suggested that it may be a determinant of metastatic and invasive behavior in carcinomas. The immunohistochemical expression of CD44 was examined in a series of 34 squamous cell carcinomas, 13 in situ carcinomas, 35 cases w...
Clinical studies in several tumour types have shown a strong correlation between cathepsin D expression and tumour progression. Immunohistochemical staining for cathepsin D (clone D13A) was performed in paraffin embedded-tissues from 39 invasive squamous cell carcinomas, 13 in situ carcinomas, 35 cases of dysplasia, 10 papillomas and 17 cases of ke...
In this study we evaluated the immunohistochemical expression of metallothionein (MT) in 44 squamous cell carcinomas, 14 cases of in situ carcinoma, 47 with epithelial dysplasia, 11 papillomas and 21 cases of keratosis. The MT expression was studied in correlation with p53 protein expression and the proliferative cell nuclear antigen (PCNA). The mo...
The purpose of this study was to investigate if there is any relationship between the age of a patient and the degree of facial nerve recovery in patients with Bell's palsy. Between 1987 and 1995 250 patients with peripheral idiopathic facial nerve palsy were examined at the ENT Clinic of the University of Ioannina. In this group 134 were male and...
In order to study the altered Rb, bcl-2 and p53 proteins expression during laryngeal carcinogenesis and to elucidate the role of these molecules in the development and progression of the lesions, we have examined the immunohistochemical expression of these markers in a series of 41 squamous cell carcinomas, 14 cases of in situ carcinoma, 47 with ep...
An 81-year-old man came to the ENT Department of the University Hospital in Ioannina Greece with a large cutaneous horn of the right auricle. The horn was almost 4.5 cm long, skin colored, and had a thick, reddened base and two antler-like projections (Fig. 1).Fig. 1. Cutaneous horn of the auricle.The lesion had first appeared on the upper part of...
The purpose of this study was to evaluate the ability of electroneuronography (ENOG), also called evoked electromyography (EEMG), and facial nerve latency testing (FNLT) to assess the prognosis of facial nerve palsy, using the House-Brackmann facial nerve grading system as criterion. From 1988 to 1994 these tests were employed at the ORL Clinic of...
The aim of this prospective study was to investigate whether pregnancy predisposes to facial nerve palsy and what the specific properties of facial nerve palsy are during this period. Eight cases of idiopathic facial nerve palsy occurring during the last trimester of pregnancy are presented. Out of 50 women with idiopathic facial nerve palsy, 15 we...
In this study, we present a very rare condition in a male patient suffering from a trigle lithiasis disorder in three different drain systems such as: submandibular salivary gland, kidney and gallblader. A clinical and paraclinical therapeutic review of this type of affection as well as bibliographical study will be realized from this observation.
Sensorineural hearing loss in rheumatoid arthritis (RA) has been reported to be the result of the extraarticular manifestation of the disease (rheumatoid nodular vasculitis) or due to drug ototoxicity.
In an attempt to investigate the presence of sensorineural hearing loss and the possible causes for it we investigated prospectively 45 RA patients...
The cysts of the parotid gland are very rare lesions of congenital or acquired aetiopathogenesis. In most cases, the symptom is an unilateral painless swelling in the area of the parotid without any fixation to the overlying skin or any involvement of the facial nerve. These must be distinguished from neoplasms with a similar clinical presentation...
We report our results from the application of evoked electromyography (EEMG) and facial nerve latency testing (FNLT) in 30 children aged 4-14 years with idiopathic facial palsy. Our aim was to define the value of these tests as prognostic tools in Bell's palsy. From the EEMG results we ascertained that, when the amplitude of the compound muscle act...
The cerebrospinal fluid rhinorrhea is usually due to a skull lesion and is potentially dangerous for the patient, as it can be followed by an ascending meningitis. The extracranial approach (external ethmoidectomy, osteoplasty of the frontal sinus) has substituted craniotomy, especially in cases where the cerebrospinal fluid rhinorrhea is not due t...
In this study we present 16 cases with multiple palsy of the cranial nerves and clinical features of herpes zoster cephalicus. Besides typical cases of Ramsay Hunt syndrome, the purpose of our study is to present some atypical cases with regard to the combination of the affected cranial nerves and the lack of herpetic rash. The absence of the typic...
Zusammenfassung Wir stellen 16 Patienten mit dem klinischen Bild eines Herpes zoster cephalicus vor, bei denen gleichzeitig mehrere Hirnnerven befallen waren. Wir möchten neben der typischen Form auch manche atypischen Formen des Ramsay-Hunt-Syndroms vorstellen, wobei die Atypien entweder die Kombination der befallenen Hirnnerven oder das Fehlen de...
In the present comparative study we applied the nerve excitability test (NET) and the maximum stimulation test (MST) to 131 patients with idiopathic facial nerve palsy. Our aim was to determine their value in the evaluation of facial nerve function. Results showed that the percentage of error of the NET in the prognosis of facial nerve palsy was 16...
With the entry of a large number of Albanians in the area of Epirus over the past 8 months, a significant number of children with hearing problems or deafness has been examined in the out patient ward of the University Hospital of Ioannina. From the Pediatric-Neurologic-Psychiatric and Otorhinolaryngologic examination of these children, 18 cases wi...
The palate neoplasias are rare and come from either the minor salivary glands or the stratified epithelium. The malignant tumors of the hard palate are present 3-4 times more frequently than the malpighian carcinomas which, on the contrary, are prevailing at the soft palate. The malignant tumors of the palate may be located or extended to the neigh...
The nasal haemangiomas are a very rare cause of epistaxis and nasal obstruction. We report a case of capillary haemangioma with the appearance of a large pedunculated nasal polyp, which was located in the middle area of the right nasal cavity's roof. We also report the clinical and histopathological findings, the differential diagnosis and the ther...
Zusammenfassung In dieser Studie wurden bei insgesamt 200 Patienten zwei elektrodiagnostische Untersuchungsmethoden, die Elektroneurographie (ENG) und die qualitative Beurteilung der sichtbaren Muskelkontraktion bei supramaximaler Reizung («maximum stimulation test», MST), zur Bestimmung des Läsionstyps der idiopathischen Fazialisparese durchgeführ...
We report our results with electroneurography (ENG) and the Maximum Stimulation Test (MST) in 200 patients with idiopathic facial palsy. Our aim was to determine the prognostic value of these tests in Bell's palsy. The MST demonstrated that, when the muscle response of the affected side is within the normal limits, the neuronal damage is slight, an...
Es wird über einen 25jährigen Patienten mit einem typischen Norrie-Warburg-Syndrom berichtet. Seit dem ersten Lebensjahr besteht Erblindung und Innenohrschwerhörigkeit beiderseits. Die tonaudiometrische Untersuchung zeigte eine mittelgradige symmetrische reine Innenohrschwerhörigkeit, welche in den letzten zehn Jahren unverändert geblieben ist. Dur...
A rare case of bilateral perceptive deafness following clinical tetanus is reported. The patient was a 15-day-old neonate. The clinical tetanus was treated with tetanus antitoxin (human gamma globulins) and penicillin. The exact mechanism of auditory nerve damage associated clinical tetanus and treatment with human tetanus antitoxin and penicillin...
The presence of the Actinomyces usually is not determined by the common histologic examination of preparations of tonsillar tissue which has been removed surgically. The Actinomyces are common saprophytic microorganisms which are found inter alia in the oral cavity and palatine tonsils. In this study, the authors examined histologically 238 surgica...
The malignant melanomas are expansive tumors of neoplastic melanocytes. In the present study, five cases of patients are reported which have been hospitalized in E.N.T. department of our hospital during the last four years with skin melanomas of the head and neck. We note our opinions on diagnosis and treatment of these malignant tumors.
Management of intractable posterior epistaxis remains a challenge to the otolaryngologist. When anterior and posterior packing techniques fail to control the hemorrhage, a surgical technique designed to interrupt the blood supply to the posterior parts of the nose is indicated. The common procedures employ ligation of the external carotid artery, o...
In this study, primary we present briefly the main anatomic elements that concern the tongue as also the clinical and other structures of the cancer of the oral cavity. Simultaneously, we notice our experience from the use of the tongue flap in 16 patients with cancer of the floor of the oral cavity. This procedure is simple, easy, brief and it doe...
In this article is presented a case report of a 59 years old woman with a medical history of recurrent nasal polyps (from 20 years ago). This woman presented an inverted papilloma in the middle meatus of the lateral wall of the nasal cavity simultaneously with the nasal polyps, and she was faced with surgical intranasal removal. The patient, two ye...
An extra aberrant salivary gland located in a branchial cyst is presented. The branchial cysts are usually the result of a transformation disturbance of the branchial clefts and arches, or are cystic changes of the lymph nodes. The above finding can possibly be interpreted if we suppose that an aberrant salivary gland located in a lymph node can de...
Es wird über einen Patienten mit einer lateralen Halszyste berichtet, welche eine aberrierende heterotope Speicheldrüse beinhaltet. Laterale Halszysten werden meistens als Folge von Störungen im Verlauf der Umbildungsvorgänge an Kiemenfurchen und Schlundtasehen angesehen, beziehungsweise auf zystische Veränderungen in den zervikalen Lymphknoten. Da...
We report an 11-year-old child who aspirated a toy balloon causing death by asphyxia. Children who chew balloons while running and who breathe deeply or laugh at the same time are under great risk. The saliva which smears the balloon makes it easier to slide into the airway. Therefore chewing of balloons by children must be avoided because of the d...
In the present treatise, a classification scheme for macroglossia has been formulated, based on clinical and etiological features of an enlarged tongue. The pathogenesis of each form-type of macroglossia is then described. In addition to, the authors report a case of female patient suffering from macroglossia, who was admitted in their Clinic. This...
Zusammenfassung Es wird über 4 Fälle mit chronischer Otitis media und erheblichem Abfall der Innenohrkomponente im Tonaudiogramm berichtet. Zwei Patienten hatten eine Cholesteatomeiterung mit Labyrinthfistel, einer sogar mit einer doppelten Fistel sowohl am horizontalen als auch am hinteren oberen Bogengang, der dritte litt an einer granulierenden...
The conductive hearing of 18 patients with juvenile chronic arthritis was studied. Tympanometry was therefore undertaken for the assessment of functional state of the tympanic membrane, the ossicular chain with its ligaments and muscles, and the air cushion of the tympanic cavity. Acoustic reflex was present in all patients but an abnormal tympanom...
Lateral cervical sinuses of fistula are usually derivatives of the branchial clefts and pouches and have a more or less typical course in the neck. We present a patient with an extremely long sinus extending from the left supraclavicular area, via the cheek up to the left infraorbital rim. We could not find a similar report in literature. The diagn...
We present a case of otogenic abscess of the brain that ruptured into the ipsilateral cerebral ventricle. All the diagnostic, surgical and postoperative procedures which led not only to saving this patient but also his complete recovery are described. Because there is a great difference between rupture of a cerebral abscess into a ventricle and rup...
Laterale Halsfisteln und Zysten sind meistens Residuen der embryonalen Kiemenfurchen und Schlundtaschen und haben einen mehr oder weniger typischen Verlauf im Hals. Es wird ein Patient mit einer ungewöhnlich langen Fistel vorgestellt, die von der linken supraklavikulären Region über die linke Wange bis zur ipsilateralen Infraorbitalregion reichte....
Citations
... Die meist nahrungsabhängige Sekretion ist jedoch nicht immer von Geburt an vorhanden, sondern kann erst in späteren Lebensjahrzehnten auftreten [16]. Sowohl hierdurch als auch durch das Auftreten von aberriertem Speicheldrüsengewebe innerhalb von Halszysten wird die differentialdiagnostische Abgrenzung gegenüber branchiogenen Strukturen erschwert [13,14]. ...
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... This mutation was very common in European countries in which the frequency of the mutation is the same, high or low than the frequency reported in the countries of North Africa: France (43%), Italy (31%), Germany (16.7%), Portugal (13.5%), Greece (35.27%) (Amorini et al., 2015;Dória et al., 2015;Feldmann et al., 2004;Iliades et al., 2002;Zoll et al., 2003). ...
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... Se define el empiema cerebral como una infección piogénica que se da en un espacio anatómico sin alteraciones previas. Si se habla de empiema subdural, se encuentra entre la duramadre y la aracnoides (1,2,3). Corresponde del 13% al 23% de las infecciones encefálicas (3) y representa del 10% al 40% de las infecciones supurativas que se presentan en esa área (2,4). ...
... [14] Bell palsy and SSNHL are thought to have an etiology of viral infection. [16][17][18][19][20][21] The lesion is in the vestibular nerve in VN, and VN is the vestibular nerve equivalent of SSNHL. [7] Thus, seasonal variations of Bell palsy and SSNHL could be considered to verify seasonal variations of VN. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/979905705697284-1610639134678_Q64/Aristides-Bartzokas.jpg)
... Physical examination may reveal the presence of a nasal mass or polyposis [267]. A mass may be present in the cheek or the medial canthus or be found as broadening of the nasal dorsum. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1100255038849024-1639332651094_Q64/Mahbube-Bai.jpg)
... In all three cases deafness followed clinical signs of serum sickness [15]. More recently perceptive deafness was described in a survivor of neonatal tetanus treated with human antitoxin without any signs of serum sickness and was attributed to a direct effect of tetanus toxin itself [16]. ...
... About 6.7-35% of tonsillectomy specimens have been reported to have actinomyces colonies. 1,3,4 The disease is predominantly characterized by spread to contiguous tissues as it disrupts mucosal barriers and it can masquerade as any oropharyngeal malignancy/any oropharyngeal lesions. 5 Main cause of disruption is dental caries or trauma, surgery or another infection. ...
... The overall mortality rate of foreign body aspiration is approximately 5-7% [3]. FBA with complete airway obstruction is responsible for majority of the mortality cases immediately after the injuries [1,[4][5][6][7]. Although FBA with incomplete airway obstruction is not a cause of instant death, it can result in significant morbidities, complications, and delayed deaths [8]. ...
... In addition, RA, by way of vasculitis or neuropathy, could also cause sensorineural HL or labyrinthine dysfunction [9,10]. Ototoxicity of RA medications used for the treatment of the disease has been also reported by previous data [7,10]. ...
... Without advanced imaging technology and immediate intervention by a neurosurgeon, interhemispheric abscess has poor prognosis because of vital location, difficulty in diagnosis, and drainage [10]. Abscess rupturing into the ventricle or ventricle rupturing into the abscess with consequent fate of the patient is well described by Bliouras et al [11] and Miyamoto et al [12]. Nevertheless, early diagnosis and immediate surgical intervention lead to a better prognosis [5]. ...
