A. Sanjivani’s scientific contributions

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Publications (1)


Development and evaluation of hollow microspheres of clarithromycin as a gastroretentive drug delivery system using eudragit polymers
  • Article

January 2011

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153 Reads

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18 Citations

International Journal of Pharma and Bio Sciences

A. Sanjivani

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S. Swapnila

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[...]

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S. Jagdish

The present study deals with an attempt to develop hollow floating microspheres of Clarithromycin for gastro retention using Eudragit polymers prepared by emulsion solvent diffusion method. Eudragit S 100, RS 100, RL 100, L 100 and L 100 55 were used to prepare hollow microspheres. A drug - excipients compatibility study was performed using FTIR. The microspheres were characterized for shape and surface morphology by scanning electron microscopy. They were evaluated for particle size, flow properties, bulk density, % drug entrapment efficiency, floating properties and in-vitro drug release. The residual solvent content was determined after varying the stirring time. Drug to polymer ratio was varied from 1: 1 to 1: 3 and its effect on particle size and drug release was studied. The microspheres exhibited round shape, porous surface, prolonged drug release and buoyancy for more than eight hours. As the drug to polymer ratio increased the particle size increased and the drug release rate decreased.

Citations (1)


... The formula below represents the percentage yield of floating microspheres, which is derived by dividing the actual product weight by the sum of all the non-volatile ingredients employed in their synthesis. [31,32] Drug entrapment efficiency: By immersing the weighted amounts of crushed microspheres in the necessary quantity of 0.1 N HCl and analysing spectrophotometrically at a certain wavelength utilizing the calibration curve, it is possible to estimate the amount of drug content in floating microspheres. Each batch should undergo a triplicate drug content analysis. ...

Reference:

A Comprehensive Review on Hollow Microspheres Gastroretentive Drug Delivery System
Development and evaluation of hollow microspheres of clarithromycin as a gastroretentive drug delivery system using eudragit polymers
  • Citing Article
  • January 2011

International Journal of Pharma and Bio Sciences