A S Thambiah's research while affiliated with Madras Medical College and other places

Publications (120)

Article
A thorn of Prosopis spicigera has been detected in vivo in two cases of chronic skin granulomas. It coexisted with an actinomycotic mycetoma in one case. In the other case there was no foreign body giant cell reaction or mycetoma. The relationship between a thorn prick and the development of mycetoma is re-emphazised. Zusammenfassung: Bei zwei Pati...
Article
A case of giant cell granuloma caused by Trichophyton rubrum is reported. Clinically the fungus had elicited skin coloured flat topped papules and plaques. Fungal filaments were absent in these areas histologically though skin scales revealed mycelia in KOH mount and grew T. rubrum. The histological findings suggest that histiocytes and plasma cell...
Article
Amino acid patterns in the mycelia of 9 dermatophytes have been studied on minimal and complex media. A greater number of amino acids was detected in the mycelia of dermatophytes grown in complex medium than those grown in various minimal media. Their preference for protein and complex media is emphasised.Zusammenfassung: Das Aminosäuremuster in de...
Article
Intrafamilial incidence of tinea capitis in 26 families was studied in Madras and was found to vary from 3.6 % to 80.0%. Usually the incidence was higher in noninflammatory types caused by Trichophyton violaceum infection than those with inflammatory lesions or kerion. Poor socioeconomic and hygienic background was found in most of the families stu...
Article
A total of 45 cases of dermatophytoses were subjected to a trial with econazole (22 cases) and clotrimazole (23 cases) creams. 100% cure rate was observed in both groups with no side effects. Their ability to cure endothrix infection in vellus hairs is interesting and encouraging and are worth a trial in tinea capitis and tinea unguium. Zusammenfas...
Article
A study of pityriasis versicolor was done in a total of 100 each of males and females. Incidence of the disease was equally high during summer (April) and winter (October). The adolescents were affected mainly. General hygiene showed no relevance to the disease. The lesions commonly occurred over the upper trunk and face. Hands, feet and ears were...
Article
Lymphoedema with subsequent elephantiasis as sequelae to chronic basidiobolomycosis in one of our previously reported cases is described. The possible prevention of such changes in this infection when detected and treated in its earlier stages before lymph node invasion is emphasised. Zusammenfassung: Beschreibung emes Lymphödems mit nachfolgender...
Article
Dermatophytosis occuring concomitantly with pemphigus vulgaris and erythematosus in three cases has been described. The absence of invasion of the fungus into the bulla or the roof other than stratum corneum and its localised nature without spread to other sites in these patients under long term prednisolone therapy suggests an undisturbed immune d...
Article
Histological studies in 50 cases of tinea capitis caused mainly by Trichophyton violaceum have shown three distinct varieties which correlated with their clinical types. Findings in the present and previous studies on tinea capitis correlate a higher incidence of the disease in noninflammatory types and a lower incidence in the inflammatory types....
Article
Erythema multiforme (EMF) due to dermatophytosis caused by Tricho-phyton rubrum has been described in a 64 year old male with grandmal. Specific treatment with oral griseofulvin cleared the condition in 3 weeks time. This case is reported for the rarity of EMF being produced by an anthropophilic dermatophyte, Trichophyton rubrum. Zusammenfassung: E...
Article
The occurrence of pyogenic granuloma following nose-boring for the wearing of ornaments is recorded. Boring of the nose is seen in 60–70% of women in our skin out-patient department and pyogenic granuloma occurs in 33% of such women. The condition is not encountered after boring of the ear lobes, and this suggests that the tissues of the alae nasi...
Article
Dermatophytosis was detected in 42% of 100 renal transplant recipients screened, of whom 17% had the infection for more than 1 year. Tinea cruris and tinea corporis were the common clinical types observed. Tinea unguium presented as proximal subungual white onychomycosis (PSWO) in 3% of patients. The lesions in the majority were non-inflammatory, s...
Article
A case of deep dermatophytosis in the gluteal region in a male patient successfully treated with terbinafine is described with its clinical, mycological and histopathological features.
Article
Chronic dermatophytosis was observed in 2276 (10.02%) of 22 692 patients with dermatophytosis during a period of 5.5 years. Males were affected at least 3 times more frequently than females. The age group most commonly affected was between 20 and 40 years of age. Females were affected more between the ages of 30 to 40 years. Tinea cruris and tinea...
Article
A case of plaque type blue naevus was encountered in a Dermatology Clinic in Madras. The various clinical differential diagnoses are discussed, the hitopathological features described and the benign nature of the tumour stressed. The case is reported for its rarity and to create an awareness of this entity.
Article
A rare disorder of periodic Peeling Skin Syndrome, encountered in an adult male in a tropical skin clinic in Chennai, is reported along with its histopathological features.
Article
Chronic paronychia associated with black discoloration of the left thumb nail in a 51 year old female caused by Curvularia lunata is reported for the first time. The keratolytic activity of the fungus in the nail and its complete clearance by topical clotrimazole are reported.
Article
Of 500 individuals screened at the Out-Patient Clinic, Mycology Section of the Department of Dermatology, Government General Hospital, Madras, 83 adult males (16.6%) and two adult females (0.4%) had hairy ears. Family study in five probands (three males and two females) suggests an autosomal-dominant sex-limited inheritance of this entity, probably...
Article
Of 269 patients with cutaneous trichosporosis a majority of 170 (63.2%) showed the infection as intertrigo in the genitocrural and perianal areas. The predominant symptoms were itching and burning. Trichosporosis has been found to be less common in the other sites. Trichosporosis due to Trichosporon beigelii should be kept in mind as one of the dif...
Article
Twenty seven cases of actionomycotic mycetoma caused either by Actinomadura madurae or Actinomadura pelletierii have been described. Infection by A. madurae has been more common than A. pelletierii. Left foot in A. madurae and right foot in A. pelletierii infections were involved more commonly in adult males, whereas right foot of the females was f...
Article
Multiple melanotic macules of varying sizes were present on the palmar surfaces of 42 of 50 consecutive South Indian patients with von Recklinghausen's disease. The histologic characteristics of the macules showed localized areas of fingerlike prolongations of the rete ridges with increased pigmentation of the basal cells. This epidermal change ove...
Article
Fast spreading familial infection by Trichophyton simii has been reported in 2 families from South India. All members within 5 days in one family and 6 of the 7 members within 18 days in the second family were infected. All showed inflammed eczematous skin plaques and the number of lesions in each individual varied from 1 to 5. Exposed parts of the...
Article
Tinea capitis and tinea facei resembling chronic discoid lupus erythematosus (CDLE) caused by Trichophyton tonsurans in an adult female is described. Tinea corporis of the waist resembling lichen planus (LP) and tinea unguium due to the same organism were also observed in her. Hypopituitrism was the associated disease and long-term oral griseofulvi...
Article
A boy of 5 years with dominant ichthyosis vulgaris with no immune deficiencies and who had extensive dermatophytosis caused by Trichophyton mentagrophytes and candidosis of oral mucosa, nails and paronychia was successfully treated with oral ketoconazole. Zusammenfassung: Ein 5jähriger Junge, bei dem auf dem Boden einer dominanten Ichthyosis vulgar...
Article
Invasion of muscle tissue in addition to dermis and subcutaneous tissue by Basidiobolus haptosporus is reported in a 40-year-old female housewife. This infection followed intramuscular injection injury of the right gluteal region. Oral KI cured the condition completely in 6 months. Intramuscular implantation of B. haptosporus by the injection needl...
Article
Tinea nigra due to Exophiala werneckii in a 27 year old male labourer is reported for the first time from Madras, South India and is the second case recorded in India. Hyperhidrosis at the site of infection was an interesting feature in this case and 1 % econazole cream cleared the infection and hyperhidrosis in 6 weeks. Zusammenfassung: Erster Ber...
Article
A case of localised sporotrichosis of the right forearm in a 36 year old female housewife is reported. This is the first case recorded in our department, Madras. Localised infection without a lymphatic spread is probably related to the inability of this isolate, Sporothrix schenckii, to grow at 37°C in vitro. Zusammenfassung: Bericht über eine loka...
Article
A 50-year-old woman reported in July 1974 with brownish spiky lesions on palms and soles of about one year duration. The condition was asymptomatic and manual removal of the spiky lesions left behind pits. Family history was noncontributory, and there was no history of exposure to arsenic. The palms showed filiform and acuminate lesions measuring 1...
Article
Basidiobolomycosis following intramuscular injection in a 6 year old female child is reported. Regional lymph nodes in the inguinal areas on both sides conforms to such findings in our previous cases, denoting that this infection is systemic. Simple oral potassium iodide (KI) has cured the disease without a relapse during follow up of nearly 3 year...
Article
Actinomycotic mycetoma caused by Actinomadura madurae has been described with sporotrichosis like distribution along the regional lymphatic drainage. Complete remission occurred in 3 years with oral tetracycline. Zusammenfassung: Beschreibung eines actinomykotischen Mycetoms, das durch Actinomadura rnadurae hervorgerufen wurde und das eine Sporotri...
Article
Extensive and chronic tinea glabrosa in one infant and a chronic tinea manuum and tinea unguium in another due to Trichophyton rubrum infection have been described. X-linked ichthyosis in vulgaris in the former and ichthyosis vulgaris (dominant) in the latter case were the associated conditions. The slow epidermal turnover and slow nail growth are...
Article
Extensive and chronic tinea glabrosa in one infant and a chronic tinea manuum and tinea unguium in another due to Trichophyton rubrum infection have been described. X-Linked ichthyosis vulgaris in the former and ichthyosis vulgaris (dominant) in the latter case were the associated conditions. The slow epidermal turnover and slow nail growth are the...
Article
A case of focal dermal hypoplasia syndrome with additional features of white lines, dotted ridges and extradigital transverse creases is described.
Article
Tinea capitis due to Trichophyton violaceum was seen in 34% of 157 Anglo-Indian female children at Madras. The common age group and the class affected were between 10 and 15 years and 6th and 7th standards. A proportionally higher number of children were present in this group. T. violaceum infection in areas other than the scalp was negligible.
Article
A case of dermatophytosis treated with oral griseofulvin developed fixed drug eruption to the drug. The present report is the second of its kind observed in world literature. Zusammenfassung: Bei einem Patienten, der wegen einer Dermatophytose Griseofulvin oral erhielt, entwickelte sich ein fixes Arzneimittelexanthem. Dieses ist der zweite berichte...
Article
Amino acid patterns in the mycelia of 9 dermatophytes have been studied on minimal and complex media. A greater number of amino acids was detected in the mycelia of dermatophytes grown in complex medium than those grown in various minimal media. Their preference for protein and complex media is emphasised. 0,6378
Article
Histological studies in 50 cases of tinea capitis caused mainly by 0,5346 Trichophyton violaceum have shown three distinct varieties which correlated with their clinical types. Findings in the present and previous studies on tinea capitis correlate a higher incidence of the disease in noninflammatory types and a lower incidence in the inflammatory...
Article
Ten cases of pemphigus vegetans of Neumann type are reported. Six of these showed clinically distinctive changes in the tongue for which the term cerebriform tongue is proposed. Histological examination of the tongue showed typical features of pemphigus vegetans.
Article
Acquired hair shaft abnormalities resembling genetic trichorrhexis nodosa were seen in two patients. Selenium shampoo and bacterial infection with trichomycosis axillaris may have been the contributing factors. There is a possibility that strongyloides larvae caused trichonodosis in one patient.
Article
A case of actinomycotic mycetoma with vesiculation showing suprabasal bulla superjacent to the grains of Actinomadura madurae has been reported. During routine histological studies such findings should alert one to diseases other than Darier's and the pemphigus group of diseases wherein suprabasal separation is a constant feature. Vesiculation is k...
Article
Tinea facei caused by Microsporum gypseum in an infant at the age of two days is reported. This culturally proved infection is the first of its kind in an infant and is the youngest case recorded in the world literature. The source has been the soil surrounding the house from where the same species has been isolated. This case also records the shor...
Article
Association of ainhum and cutaneous trichosporosis by Trichosporon cutaneum in 4 cases are reported. Z-plasty in 1 along with local application of dequalenium chloride were helpful in relieving the disorder. The possible role played by Trichosporon cutaneum in initiating or aggravating ainhum is emphasized.Copyright © 1981 S. Karger AG, Basel
Article
The incidence of mycoses is high in Madras accounting for over 13% of dermatoses diagnosed in a three-year period. Dermatophytoses (tinea corporis and tinea cruris) and pityriasis versicolor were most common in May and October. A correlation was observed between these infections and environmental temperature, humidity and rainfall. Most cases of al...
Article
A total of 45 cases of dermatophytoses were subjected to a trial with econazole (22 cases) and clotrimazole (23 cases) creams. 100% cure rate was observed in both groups with no side effects. Their ability to cure endothrix infection in vellus hairs is interesting and encouraging and are worth a trial in tinea capitis and tinea unguium.
Article
SUMMARYA case is reported showing insulin resistant diabetes mellitus with acanthosis nigricans, clitoral hypertrophy and the typical facies of the Lawrence-Seip syndrome.
Article
Dermatophytosis occurring concomitantly with pemphigus vulgaris and erythematosus in 3 cases has been described. The absence of invasion of the fungus into the bulla or the roof other than stratum corneum and its localised nature without spread to other sites in these patients under long term prednisolone therapy suggests an undisturbed immune defe...
Article
Cutaneous candidosis of the nipple in a mother originating from candidal perleche in her child is described with the contagious nature of the organism.
Article
Cutaneous candidosis of the nipple in a mother originating from candidal perleche in her child is described with the contagious nature of the organism. Zusammenfassung: Cutane Candidose der Brustwarze bei einer stillenden Mutter. Die Candidose entstand durch Ansteckung von einer Candida-Perkèche bei dem gestillten Säugling. Der Fall wird dargestell...
Article
Tuberous sclerosis, an autosomal dominant disorder, is characterised by skin lesions, mental retardation and epilepsy. A retrospective study was carried out on ten cases. Our findings were consistent with those in recent relevant literature which is reviewed here. Palmar dermatoglyphic patterns were studied in seven cases.
Article
A study of Tinea capitis in Outpatient Clinic, Skin Department, Government General Hospital, Madras during a three year period from November, 1973 to October, 1976, has shown a gradual increase in incidence of 3.56%, 5.09% and 6.25% respectively. Findings suggest that Tinea capitis is endemic in South India. Male children were more commonly affecte...
Article
Tylosis at birth was found as an autosomal dominant inheritance in twenty-two members of a family spanning over five generations. Of those affected three of the fourth generation tylotics developed squamous carcinoma of the tylotic skin and one of these died of carcinoma of the oesophagus. It is possible that there is a genetic association between...
Article
Growth pattern of certain dermatophytes in varied substrates with their biochemical constituents have been studied. This study was carried out with isolates obtained from patients of Madras, India. It was observed that better growth and higher amounts of cell constituents occurred in media with proteins and complex media like Sabourad's dextrose li...
Article
Cutaneous infection of the thumb by a Syncephalastrum sp. is described in an adult male suffering from diabetic ketosis. The fungus was isolated from the skin and was found to produce arteritis in the dermal vessels. The patient died of diabetes mellitus without any associated systemic mycosis. Syncephalastrum in this case had occurred as an opport...
Article
Growth pattern of certain dermatophytes in varied substrates with their biochemical constituents have been studied. This study was carried out with isolates obtained from patients of Madras, India. It was observed that better growth and higher amounts of cell constituents occurred in media with proteins and complex media like Sabouraud's dextrose l...
Article
Two cases of cutaneous adiaspiromycosis by Emmonsia crescens are reported. This is the first human skin infection by this species and is the first report of its kind in man from India. In the first patient, the agent was demonstrated in KOH mounts, histology and culture from irregular, pigmented skin plaques on the right gluteal area. The lesion al...
Article
In an uncontrolled preliminary trial, metronidazole administered orally to 30 patients was effective in resoving tropical phagedenic ulcers within a period of one to two weeks. The efficacy of this drug indicates the important role played by fusospirochetes in causing tropical ulcers.
Article
A study on tinea capitis was carried out in 2 schools in Madras city during 1973 to 1975. Fifteen of 241 (6.22%) children in one school and 48 children and an adult out of 82 (59.75%) in the second school were detected to suffer from tinea capitis due to Trichophyton violaceum. The children in both the schools belonged to unrelated families. Tricho...
Article
Intrafamilial incidence of tinea capitis in 26 families was studied in Madras and was found to vary from 3.6% to 80.0%. Usually the incidence was higher in noninflammatory types caused by Trichophyton violaceum infection than those with inflammatory lesions or kerion. Poor socioeconomic and hygienic background was found in most of the families stud...
Article
A study of pityriasis versicolor was done in a total of 200 males and females. Incidence of the disease was equally high during summer (April) and winter (October). The adolescents were affected mainly. General hygiene showed no relevance to the disease. The lesions commonly occurred over the upper trunk and face. Hands feet and ears were rarely in...
Article
: Fifty-one patients with trichostasis spinulosa were studied. Lesions were confined to the nose, where a maximum of 86 hairs were found in a single hair follicle. Histologically, compound hair follicles with numerous vellous hairs and keratin filled sebaceous glands were observed. Compound hair follicles influenced by endocrines and probably actin...
Article
The occurrence of pyogenic granuloma following nose-boring for the wearing of ornaments is recorded. Boring of the nose is seen in 60--70% of women in our skin out-patient department and pyogenic granuloma occurs in 33% of such women. The condition is not encountered after boring of the ear lobes, and this suggests that the tissues of the alae nasi...
Article
Entomophthoromycosis basidiobolae in a 2½ year old female child is described with clinical, mycological and histopathological findings. Oral potassium iodide resolved the condition successfully. Zusammenfassung: Entomophthoromycosis basidiobolae in einem zweieinhalbjährigen Kind (Mädchen) wird mit Angaben von klinischen, mykologischen und histopath...
Article
Trichophyton simii produced kerion on the intact forearm skin due to a laboratory accident within 5 days of contact. Early institution of griseofulvin resolved the condition in 15 days with no recurrence during 38 months of follow-up.
Article
Lymph node invasion with presence of conidia, their replicates, germ tubes, condidia with hair-like projections and hyphae have been observed in a case of entomophthoromycosis caused by Conidiobolus coronatus. This rare occurrence of conidia with hair-like projections that is usually observed in vitro, has been observed in vivo, in the content of a...
Article
Focal dermal hypoplasia syndrome is a genodermatosis characterised by mesodermal and ectodermal dysplasia. A one year old female child of small stature with typical features of this syndrome is reported here. In addition to the cutaneous lesions of soft boggy nodules and linear atrophic hypopigmented and hyperpigmented lesions the child had onychoa...
Article
A case of umbilical endometrioma is reported for its rarity. The tumour was excised together with the umbilicus.
Article
One hundred subjects with extensive pityriasis versicolor determined clinically and confirmed by wet preparations (potassium hydroxide positive) were studied. Its incidence in relation to sex, seasons and age groups was analyzed. More than fifty patients sought medical advice on grounds of cosmetic handicap. The most pronounced clinical feature was...
Article
Ectrodactyly, a complete or partial absence of one or more digits, may occur along with congenital anonychia. Such bony absences are usually accompanied by bizarre digital anomalies. Anonychia congenita can be tentatively classified into isolated and dominantly or recessively inherited cases. Their pedigree reported here is unique in that all the a...
Article
Cryptococcus laurentii was isolated twice from cutaneous granulomas in the leg and foot of a 40-year-old man. Histologically the cells of C. laurentii were found in groups in the dermis and also inside giant cells. There was epithelioid cell infiltration in the dermis and subcutis. An atypical mycobacterium was isolated in addition to C. laurentii....
Article
To the Editor.— A case of pachyonychia congenita with cardiac involvement has been recorded and reported. A 9-year-old girl had all the characteristic features of pachyonychia congenita. In addition, there was clinical and roentgenographic evidence of cardiomegaly, with abnormal ECG and angiographic studies. She also had a pigmented nevus in the l...
Article
SUMMARYA case with encapsulated Tricophyton violaceum abscesses in the skin is recorded. Defective cell mediated immunity was shown in the patient and in his two cousins. This defect combined with malnutrition, hypoadrenalism and griseofulvin resistance gave unusual lesions and chronicity. A probable genetic factor for the defective cell mediated i...