A Prentice's research while affiliated with University of Cambridge and other places

Publications (155)

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In the Maternal Vitamin D Osteoporosis Study (MAVIDOS) randomized trial, vitamin D supplementation in pregnancy did not lead to greater neonatal bone mass across the trial as a whole, but, in a prespecified secondary analysis by season of birth, led to greater neonatal bone mass among winter-born babies. Demonstrating persistence of this effect int...
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Vitamin D plays a role in muscle function through genomic and non-genomic processes. The objective of this RCT was to determine the effect of monthly supplemental vitamin D3 onmuscle function in 70+ years old adults. Participants (n = 379) were randomized to receive, 12,000 IU, 24,000 IU or 48,000 IU of vitamin D3 monthly for 12 months. Standardize...
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Dietary potential renal acid load and net acid excretion in rural and urban pre-menopausal Gambian women - Volume 76 Issue OCE4 - G.R. Goldberg, S.E. Dalzell, L.M.A. Jarjou, K. Ward, A. Prentice
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Dietary intakes of Gambian women: impact of the nutrition transition - Volume 76 Issue OCE4 - S.E. Dalzell, L.M.A. Jarjou, A. Prentice, K. Ward, G.R. Goldberg
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Bone health in Gambian women: impact and implications of rural-to-urban migration and the nutrition transition - Volume 76 Issue OCE4 - S.E. Dalzell, L.M.A. Jarjou, A. Prentice, K. Ward, G.R. Goldberg
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Maternal bone mineral changes during pregnancy as measured by peripheral QCT in rural Gambian women with a habitually low calcium intake - Volume 76 Issue OCE4 - M.Ó. Breasail, S. Schoenbuchner, L. Jarjou, S.E. Moore, A. Prentice, K.A. Ward
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CONTEXT: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. OBJECTIVE: We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol. DESIGN: Within-randomization-group analysis of p...
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Debilitating rickets-like lower limb deformities are common in children throughout the world, particularly in Malawi, Africa where the causes are unknown. We have identified that Blount disease and calcium deficiency rickets are the likely causes of these deformities and propose calcium supplementation as a potential treatment of Malawian rickets....
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Background Yoghurt is part of the diet of many people worldwide and is commonly recognized as a 'health food'. Epidemiological studies suggest yoghurt may be useful as part of weight management programs. In the absence of comprehensive systematic reviews, this systematic review investigated the effect of yoghurt consumption by apparently healthy ad...
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Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin D binding protein (DBP). The composite genotype o...
Article
The aim of this study was to estimate the burden of childhood rickets-like bone deformity in a rural region of West Africa where rickets has been reported in association with a low calcium intake. A population-based survey of children aged 0.5-17.9y living in the province of West Kiang, The Gambia was conducted in 2007. 6221 children, 92% of those...
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Unlabelled: Ethnic differences in renal calcium and phosphate excretion exist, which may depend on differences in their dietary intakes and regulatory factors. We report highly significant differences in urinary calcium and phosphate excretion between white British and Gambian adults after statistical adjustment for mineral intakes, indicating an...
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Unlabelled: Predictors of 25(OH)D3 half-life were factors associated with vitamin D metabolism, but were different between people in The Gambia and the UK. Country was the strongest predictor of plasma 25(OH)D concentration, probably as a marker of UVB exposure. 25(OH)D3 half-life may be applied as a tool to investigate vitamin D expenditure. Int...
Poster
Plasma 25-hydroxyvitamin D (25OHD) half-life (25OHD t1/2) has been proposed as a dynamic marker of vitamin D expenditure to assess vitamin D metabolism and requirements. We have recently established a method to measure 25OHD t1/2 in humans using a small oral dose of stable isotope labelled 25OHD3 [3-2H-25OH D3 (6, 19, 19-d3)] (d3-25OHD3) (tracer),...
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Context: There is uncertainty over the equivalence of vitamins D2 and D3 to maintain plasma 25-hydroxyvitamin D (25(OH)D). Objective: The objective of the study was to compare the plasma half-lives of 25(OH)D2 and 25(OH)D3 in two distinct populations with different dietary calcium intake and 25(OH)D status. Participants: Healthy men (aged 24 a...
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Context: Calcium intake during growth is essential for future bone health but varies widely between individuals and populations. The impact on bone of increasing calcium intake is unknown in a population where low calcium intake, stunting, and delayed puberty are common. Objective: To determine the effect of prepubertal calcium supplementation o...
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The prevalence of osteoporosis and the incidence of age-related fragility fracture vary by ethnicity. There is greater than 10-fold variation in fracture probabilities between countries across the world. Mineral and bone metabolism are intimately interlinked, and both are known to exhibit patterns of daily variation, known as the diurnal rhythm (DR...
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BACKGROUND/OBJECTIVES: Previous studies in Gambian women with a low calcium intake have described decreases in whole-body and regional bone mineral content (BMC) and areal bone mineral density (aBMD) during the first year of lactation. The aim of this study was to examine whether these effects are reversed after lactation. SUBJECTS/METHODS: Thirty...
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The quote by Sir Isaac Newton, ‘If I have seen further it is by standing on ye sholders of Giants’ was the theme of the British Nutrition Foundation (BNF) Annual Lecture 2012. Illustrations of the seminal contributions of six ‘giants’ of nutrition science, chosen because of their links to the BNF and to vitamin and mineral research in Cambridge, we...
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This is the first report examining vitamin D status and bone mass in African women with HIV infection using dual-energy X-ray absorptiometry (DXA) with an appropriate HIV-negative control group. Unlike previous publications, it demonstrates no difference in bone mineral density (BMD) or vitamin D status in HIV-positive patients, at different diseas...
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This pilot study in women from The Gambia with low habitual calcium intakes showed differences in calciotropic hormones between pregnant, lactating and non-pregnant, non-lactating women similar to those in Western women. The response to oral calcium loading indicates a high degree of calcium conservation independent of reproductive status. Introduc...
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Renal conservation of calcium in Gambian compared to British older adults - Volume 72 Issue OCE4 - J. Redmond, L. M. A. Jarjou, L. Palla, A. Prentice, I. Schoenmakers
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Fibroblast growth factor 23 (FGF23) is grossly elevated in Gambian children with rickets and, at a lower prevalence, in those without bone deformities. We used western blotting to mimic the detection capabilities of the C-terminal FGF23 enzyme-linked immunosorbent assay (ELISA). Only intact FGF23 hormone was present in Gambian plasma samples from c...
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There is a paucity of information from developing countries on total calcium intake during infancy, and potential consequences for growth and bone development. Observational longitudinal study of rural Gambian infants (13 males and 17 females) at 3 and 12 months of age. Breast-milk intake and calcium concentration, weighed dietary intake, anthropom...
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Human lactation is associated with transient decreases in bone mineral density (BMD). Bone strength is related to both mass and structural geometry. This study investigated longitudinal changes of hip bone strength during lactation using hip structural analysis (HSA), which determines hip structural geometry (including areal BMD, BMDa) from dual-en...
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Parathyroid hormone (PTH) is used as a marker of vitamin D (VD) status. However, PTH depends on many other factors. The 24,25-dihydroxy VD (24,25VD) concentration may be a sensitive marker because its production is reduced in VD deficiency. The relationship between VD metabolites, their ratio and PTH was investigated in adolescents from the UK and...
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European Journal of Clinical Nutrition is a high quality, peer-reviewed journal that covers all aspects of human nutrition.
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Causes of rickets include vitamin D deficiency, inherited disorders of vitamin D metabolism, dietary calcium deficiency and disorders of renal re-absorption of phosphorus.1 We have recently seen cases of rickets in exclusively breastfed infants <6 months old born to vitamin D deficient mothers. This observation led us to speculate that rickets in s...
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Relationships between Se and Hg in erythrocytes, and between these indices and intakes of fish and other foods, were studied as an adjunct to the British National Diet and Nutrition Survey (NDNS) of young people aged 4-18 years. Hg was measured in 965 packed erythrocyte samples by inductively coupled plasma mass spectrometry. Fe measurements permit...
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To compare dietary intake and sources of phylloquinone (vitamin K1) in 4-year-old British children between 1950 and the 1990s, and report their variation by sociodemographic factors.Design: Nationally representative samples of 4-year-olds from the longitudinal Medical Research Council National Survey of Health and Development (NSHD) (1950) and the...
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To investigate plasma osteocalcin gamma-carboxylation and its relationship to plasma phylloquinone concentration and apolipoprotein E (apoE) genotype in women from three ethnic groups with differing osteoporotic fracture risk. Fasted blood samples were collected from postmenopausal Gambian (n=50), British (n=31) and Chinese women (n=23), and 11 pre...
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The incidence of hip and forearm fracture in elderly men in the United Kingdom is a public health issue, but there is limited knowledge on lifestyle factors affecting male bone health. The aim of this cross-sectional study was to evaluate the relationships between whole body and regional bone mineral status and self-reported participation time in n...
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To evaluate the diet of 16-18-y-old boys and girls with particular reference to intakes of nutrients believed to affect bone health and dietary acid-base balance. A 7-day food diary was completed between the months of October and December. Cambridge, UK. A total of 111 boys and 101 girls aged 16-18 y who were recruited into the Cambridge Bone Studi...
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To characterize nutritional differences between survey participants diagnosed with Type 2 diabetes; those without diabetes, and those with "undiagnosed diabetes" based on glycosylated haemoglobin (HbA(1c)). The 1994/5 British National Diet and Nutrition Survey, of people aged 65 years and over (mean age 78 years), included 73 respondents with diagn...
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Relationships between vitamin E status (alpha and gamma-tocopherol and their ratio in plasma), anthropometric and biochemical indices, and food and nutrient intakes, were studied in four British National Diet and Nutrition Surveys: children aged 1.5-4.5 years, young people aged 4.0-18.0 years, adults 19.0-64.0 years and adults aged > or = 65.0 year...
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To explore whether there are ethnic differences in calculated hip strength that might explain the low incidence of hip fracture in China, we used Lunar DPX 'beta' version of hip strength analysis (HAS) and hip axis length (HAL) programs to compare hip geometry, calculated strength and densitometric values from Chinese subjects in Shenyang to those...
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To review the evidence on diet and nutrition relating to osteoporosis and provide recommendations for preventing osteoporosis, in particular, osteopototic fracture. Firstly, to review the definition, diagnosis and epidemiology of osteoporosis, to discuss the difficulties in using bone mineral density to define osteoporosis risk in a world-wide cont...
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To examine zinc and vitamin A intake and status and associated dietary, socio-demographic, lifestyle and physiological factors in British young people. National Diet and Nutrition Survey of young people aged 4-18 y. Great Britain, 1997. Complete 7-day weighed dietary records were provided by 1520 participants, while 1193 provided blood samples. A t...
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Following our detailed studies of human milk calcium concentration, we hypothesized that calcium intake in pregnancy may determine human milk calcium concentration and hence the calcium intake of breastfed infants (Prentice et al. 1994). To test this, we conducted a controlled calcium supplementation study in pregnant women accustomed to a low calc...
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Mentally impaired older people are frequently excluded from population surveys for practical reasons; thus their nutritional characteristics are poorly delineated. To describe the nutritional characteristics of those who, through mental impairment, were considered to require proxy consent and/or proxy information-givers, within a National Diet and...
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to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom. a population-based cross-sectional analysis of 3,511 people aged 65 years or older from three studies was used to estimate the age-specific prevalence of vitamin B12 deficiency and of fol...
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To explore whether there are ethnic differences in relationships among parathyroid hormone (PTH), vitamin D, and bone mineral status, 352 healthy volunteers, 60-83 years old, were studied in Shenyang, Peoples' Republic of China (108 men, 110 women), and in Cambridge, UK (67 men, 67 women), in late winter. Early morning fasting blood and 2-h fasting...
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To examine the prevalence and dietary, sociodemographic and lifestyle risk factors of low iron intake and poor iron status in British young people. National Diet and Nutrition Survey of young people aged 4-18 years. Great Britain, 1997. In total, 1699 young people provided 7-day weighed dietary records, of which 11% were excluded because the partic...
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The British National Diet and Nutrition Survey of people aged 65 years and over in 1994-5 provided nationally representative estimates of food and nutrient intakes and biochemical status indices. In a further analysis study, parathyroid hormone (PTH) concentrations were measured in plasma samples from 773 subjects and were analyzed with the existin...
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Assessment of functional vitamin B(12) status in a subset of the respondents in the British National Diet and Nutrition Survey of people aged 65 y and over. National Diet and Nutrition Survey: a British nationwide cross-sectional sample of people aged 65 y and over, living either in the community or in institutions such as nursing homes, during one...