A I Krotov’s research while affiliated with Moscow Institute of Psychoanalysis and other places

... [29][30] Perimidines exhibit antihelminthic activity. [31][32][33] Neurotropic active systems (stimulants and depressants of the central nervous system have been found out by using perimidines. [34][35][36] Some compounds reveals good antitumor. ...

Reference:

Review on Perimidines: A synthetic Pathways Approach

... The AIJ was prepared by adding 1.8 g of pancreatin, 1.2 g of edible soda, 24 ml of freshly obtained (thawed, concentrated) ruminant bile, and 20 ml of EDTA trypsin to 100 ml of distilled water (Table 1) 7,8,14 . The resulting mixture was poured into a magnetic stirrer, turned on the magnet rotation mode to 500 rpm, and held for 5 minutes. ...

Reference:

Biological Properties of Oncospheres of Echinococcus spp.

... For these reasons, many investigators consider the mouse model of hookworm to be non-physiological. Despite that, mice have been used to evaluate numerous chemotherapeutic agents (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) and vaccine candidates (21,40 -46) by assessing exacerbation or mitigation of skin and lung infiltrates. Of note, a successful vaccination with γ -irradiated N. americanus in BALB/c mice suggests that a localized Th2 response with an enhanced secretion of IL-4 and a higher IL-4/IFN-γ protein ratio may be important to confer protection against hookworm infections (42). ...

Reference:

Comparative immunology of human and animal models of hookworm

... Sustained-released drug effect studies (Marshall, 1982), evaluation of praziquantel activity against different developmental stages of the parasite (Campos et al., 1984), and efficacy studies on modified derivatives were performed (e.g. Tsizin et al., 1991;Mikhailitsyn et al., 1999). In addition, some studies involving praziquantel focused on the host rather than on the parasite. ...

Reference:

Cestode parasites: Application of in vivo and in vitro models for studies on the host-parasite relationship

... [9][10][11] Of particular importance is the differences in the physicochemical properties of the three known polymorphs A, B, and C. 10,12,13 For example, the difference in solubilities of these polymorphs in physiologically relevant media is B > C > A. However, due to the increased toxicity of the highly soluble form B, form C is clinically preferred because its solubility is sufficient to ensure optimal bioavailability. [14][15][16][17] This is important because polymorph A has no anthelminthic activity alone or when present above 30% in polymorphic mixtures. 15,17 Evans et al. 18 in a letter published in the South African Medical Journal asked that regulating authorities require testing to ensure that all batches of mebendazole raw material and tablets contain crystal polymorph C. ...

Reference:

Characterization of Polymorph Transformations That Decrease the Stability of Tablets Containing the WHO Essential Drug Mebendazole

... Concomitantly, studies on the effects of host influence on migration and circadian rhythm of Hymenolepis worms (Braten and Hopkins, 1969) established that adult Hymenolepis exhibited two concurrent migrations: (a) an age-dependent forward migration and (b) a circadian migration, which is influenced by the host (Tanaka and Maclnnis, 1975). This migration, which could affect, for example, the effectiveness of dehelminthization (Krotov and Rusak, 1973), seemed to be influenced by host interactive and synergistic factors, with final consequences on worm distribution in the small intestine (Dwinell et al., 2001). The influence of hormones on the course of infection was studied in the mouse model (Bailenger et al., 1972;Novak et aL, 1980). ...

Reference:

Cestode parasites: Application of in vivo and in vitro models for studies on the host-parasite relationship

... for drug screening studies. The first investigation we could identify dates back to 1971 (Krotov and Gusel'nikova 1971) . The majority of studies employed E. caproni in the mouse, and also E. ilocanum in rats and gerbils (Cross and Basaca-Sevilla 1986) , and E. miyagawai in mice (Krotov and Gusel'nikova 1971) were utilized. ...

Reference:

Use of Echinostoma spp. in studies on chemotherapy and metabolic profiling