A. Hoffer’s scientific contributions

... [13][14][15] From the 1950s until Hoffer's death in 2009, he elucidated numerous additional therapeutic uses of vitamin B 3 for the treatment of various neuropsychiatric conditions. Some of Hoffer's reports included those involving children with learning and behavioral issues, 16,17 dementia of both the Alzheimer's and non-Alzheimer's type, [18][19][20] Huntington's disease, [21][22][23] and the starvationstress syndrome (similar to post-traumatic stress disorder). 24 While Hoffer was prolific in his writings about the therapeutic uses of vitamin B 3 and other nutrients, he did not author (to my knowledge) a single report documenting the merits of vitamin B 3 for the treatment of depression. ...

Reference:

Vitamin B3 for depression: Case report and review of the literature