A. Brennan’s scientific contributions

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Publications (2)


Manual therapy for osteoarthritis of the hip or knee - A systematic review
  • Literature Review

April 2011

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2,787 Reads

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131 Citations

Manual Therapy

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A Brennan

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The aim of this systematic review was to determine if manual therapy improves pain and/or physical function in people with hip or knee OA. Eight databases were searched for randomised controlled trials (RCTs). Data were extracted and risk of bias assessed by independent reviewers. Four RCTs were eligible for inclusion (280 subjects), three of which studied people with knee OA and one studied those with hip OA. One study compared manual therapy to no treatment, one compared to placebo intervention, whilst two compared to alternative interventions. Meta-analysis was not possible due to clinical heterogeneity of the studies. One study had a low risk of bias and three had high risk of bias. All studies reported short-term effects, and long-term effects were measured in one study. There is silver level evidence that manual therapy is more effective than exercise for those with hip OA in the short and long-term. Due to the small number of RCTs and patients, this evidence could be considered to be inconclusive regarding the benefit of manual therapy on pain and function for knee or hip OA.


TABLE 1 . Change in pain pattern over 8 years
Osteoarthritis: 119. The Effectiveness of Exercise Therapy with and without Manual Therapy for Hip Osteoarthritis: A Multicentre Randomised Controlled Trial
  • Article
  • Full-text available

April 2011

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342 Reads

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1 Citation

British Journal of Rheumatology

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A. Brennan

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[...]

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Citations (2)


... We obtained 2,526 records in total, of which 1,429 were duplicate records, 1,069 records were excluded after reviewing the title and abstract, and the remaining 28 potentially related records were kept for full-text review. After closely reviewing the full text, 22 studies were excluded as follows: 2 studies were excluded due to combination with other joint osteoarthritis (11,12), 2 due to com-ments (13,14), 5 for not being RCTs (15)(16)(17)(18)(19), 2 for no manual therapy intervention group (20,21), 3 due to inadequate study protocols (22)(23)(24), 6 because of duplicate reports (25)(26)(27)(28)(29)(30), one due to an indefinite diagnosis (31), and one due to inappropriate randomization (32). Four studies (33)(34)(35)(36)(37) were identified for further review from the references of systematic reviews or related reviews, but none of them were eligible for inclusion. ...

Reference:

Manual Therapy for Hip Osteoarthritis: A Systematic Review and Meta-analysis
Osteoarthritis: 119. The Effectiveness of Exercise Therapy with and without Manual Therapy for Hip Osteoarthritis: A Multicentre Randomised Controlled Trial

British Journal of Rheumatology

... The overall number of sessions across all the included studies ranged from 12 to 48, with a median of 18 [16][17][18][19][20][21][22][23][24] sessions per study. The duration of the exercise programs exhibited variability, spanning from 4 to 12 weeks, with a mean duration of 7.1 (2.6) weeks. ...

Manual therapy for osteoarthritis of the hip or knee - A systematic review
  • Citing Article
  • April 2011

Manual Therapy